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I think fellow researchers and the science community in general can relate to this most days 🤣👨‍🔬#chemtwitter #RealTimeChem #chemX #gbbo

Check out our latest: Using smFRET, we determine an entirely new mechanism for mRNA activation. As part of this work, we assign novel functions for each of the eIF4F components, including a 'hopping' activity of eIF4G and a 'strippase' activity of eIF4A. 🔬biorxiv.org/content/10.110…

an e. coli cell is ~20 ribosomes wide

Bringing this back to stir the pot

Check out our new review of the state-of-the-art in the methods and applications of smFRET! Incredibly grateful to Taekjip Ha for leading this effort and thankful for working with the amazing Jingyi Fei, @sciSonja, Nam Ki Lee, Sanghun Yeou, and Sneha Paul! nature.com/articles/s4358…

Periodic Table Regions xkcd.com/2913

Getting today's purple connection before the rest

In (preemptive?) response to all the posts signaling the end of structural biology as we know it

I am delighted to share the newest work from the Sternberg Lab, in which we discover RNA-templated gene creation as a mechanism of antiviral immunity. This is a story for anyone who loves molecular biology, and one that repeatedly left us in disbelief. doi.org/10.1101/2024.0…

Couldn't be online a lot last week cause of the amazing #RNA2024 meeting, but our latest preprint is out! In case you couldn't catch our poster at the meeting (or if you did and want a second look :P), check out our dissection of the UUCG stem-loop dynamics!

Congratulations to Quentin Smith for the best Oral Presentation at the Nucleic Acids Forum #NAF2024

Sitting here updating my notebook and thinking how much being a wet lab scientist is like being an emo teen again "Dear diary, today I ran a gel. It did not go well"

Check out the latest work from Lori Passmore and David Rueda, out now! It was a great pleasure working with Pablo Alcón and Artur Kaczmarczyk on this amazing story!

It’s the best day of the year! RNA Day!

💎Brilliant new work from David Rueda, MRC Laboratory of Medical Sciences (LMS) Imperial Department of Infectious Disease & Structural and Synthetic Biology in nature uncovers how the SWR1 enzyme reduces genome instability by ‘flipping’ nucleosomes over to modify histones on each side. bit.ly/3NVGZNz

My co-first author paper now out in nature SWR1 specifically exchanges H2A/H2B dimers for Htz1/H2B dimers in nucleosomes. Here we show double dimer exchange can be processive, explaining how SWR1 ‘proofreads’ dimer identity in a nucleosome. nature.com/articles/s4158…

I have two PhD positions available in my group next year! These projects are looking at how disordered regions alter protein dynamics. One is through the Yorkshire BBSRC DTP, advertisement to come, but more information can be found here: whiterose-mechanisticbiology-dtp.ac.uk/yorkshire-bios…

check out our new preprint! we solved a new nuclease-blocking viral #RNA structure and found some illuminating similarities across diverse viral families. Thread below ⬇️ biorxiv.org/content/10.110…