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3D pathology. Using serially cut H&E sections and AI-based automatic annotations of cells and non-cell components, we can map the architecture/compositions of large volumes of human tissues/tumors at single-cell resolutions More here: biorxiv.org/content/10.110…

Knowledge of the contribution of somatic and germline mutations to human diseases has progressed significantly in recent years. This has led to several therapeutic treatments for cancer and monogenic diseases. Nature Reviews Genetics informative review. nature.com/articles/s4157…

Hemoglobin gene evolution in teleosts and cichlids: fish genomes have many Hb genes (up to 43) diversified from ancestral 7-8 Hb copies. Our new preprint & 1st step towards #hemoglobin function in Barombi #cichlids for Dmytro Omelchenko🇺🇦. Thks to all coauthors! biorxiv.org/content/10.110…

Lost in space: what single-cell RNA sequencing cannot tell you dlvr.it/T4zgkK

Developed using diverse sources of histopathology images, biomedical text and over 1.17 million image-caption pairs, a visual-language foundation model achieves state-of-the-art performance on a wide array of clinically relevant pathology tasks. nature.com/articles/s4159…

Nature research paper: The variation and evolution of complete human centromeres go.nature.com/3VJjaOg

Global latitudinal gradients and the evolution of body size in dinosaurs and mammals nature.com/articles/s4146… Nature Communications

How to start a PhD

science.org/doi/10.1126/sc…

ゲノミクスのトップラボ、Prof Oleg Shimakovのラボで活躍中の今鉄男先生の講演です。 とても気さくな先生で、私もくだけた感じで行きますので、研究内容はともかく、ネットワーク作りにも良いと思います。 ご興味のある方はぜひいらしてください♪

Tomorrow (September 30th), I will talk about our Hydra TE work at the "BE SINCREST/20 Year Technau Lab Reunion". This is an exciting memorial event for our department! Ulrich Technau Lab neurodevbio.univie.ac.at

高度な脳機能を持つなど、不思議さに溢れるタコなど頭足類。彼らの性決定の仕組みが判明して、4億8千万年前から❗️という、これまで知られている中で最古の性染色体を温存しているらしい。 “Octopuses Have Some of the Oldest Known Sex Chromosomes | Technology Networks“ technologynetworks.com/genomics/news/…

Our review on the potential of doctor fish as a model organism is out! Grateful for this international collaboration with Uni Vienna, Mie Univ, BRIN (Indonesia), and Akdeniz (Turkey), fostering cross-disciplinary discussions! Yasuhito SHIMADA (島田康人) Koto Kon-Nanjo, MD zoologicalletters.biomedcentral.com/articles/10.11…

Our preprint on the genome assembly of Doctor Fish (G. rufa)! G. rufa thrives above 37°C, making it a great model for cancer xenografts & infectious diseases. The assembly is a key resource for its development as a disease model. biorxiv.org/content/10.110… Yasuhito SHIMADA (島田康人) Koto Kon-Nanjo, MD

Our paper titled "Subtelomeric repeat expansion in Hydractinia symbiolongicarpus chromosomes" has been published in Mobile DNA! Subtelomeric accumulation of Helitron-like elements in Hydractinia suggests its potential role in chromosome evolution. link.springer.com/article/10.118…

成体多能性幹細胞を持つHydractiniaのゲノム論文(Kon-Nanjo, et al., 2023)のフォローアップ論文が出版されました。Helitron様の繰り返し配列がHydractiniaゲノムのサブテロメア領域に高度に蓄積していることを見出しました。link.springer.com/article/10.118…

New online! Transcriptomics in the era of long-read sequencing bit.ly/3FG0rwU

共同研究の皆様、ご協力本当にありがとうございました♪ そしてこれからもまだまだ本研究を発展させていきますので、よろしくお願いいたします♪

Finally, our genome paper on the heat-tolerant “doctor fish” is out in Scientific Data! It paves the way for studying heat tolerance and developing human cancer xenograft models at 37°C for drug screening! Worked with Mie Uni (Japan) and BRIN (Indonesia). nature.com/articles/s4159…