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Vigtig læsning!

Even mild mitral regurgitation is associated with incident atrial fibrillation in the general population academic.oup.com/ehjcimaging/ar… #EHJCVI #echofirst #Afib European Society of Cardiology Journals EACVI President Cosyns Bernard Victoria Delgado Sarah Moharem Elgamal, MBBCh, MSc, PhD👩🏻‍⚕️🫀 Sara Moscatelli Shehab Anwer, MD

Thrilled to share our meta-analysis on high-dose vs standard-dose flu vaccines in 65+ in RCTs 📝🚨 🏥📉High-dose flu vaccine reduced pneumonia/flu and all-cause hospitalizations. 🚫No significant difference in mortality rates. doi.org/10.1016/j.jinf… Tor Biering-Sørensen, MD, MSc, MPH, PhD CTCPR Trials & CIRL

Our amazing CTCPR Trials & CIRL fellows 🌟 will present 24 scientific abstracts at #ESC24 in London about the science we are generating at CTCPR Trials & CIRL. All abstract titles and times are displayed below.👇 Some of the projects will be published simultaneously with the conference. Stay tuned

We are hiring a new MD in our team! Come and join our amazing team of talented researchers and help us innovate how we conduct randomized trials using nationwide registers.

The first simpub from the CTCPR Trials & CIRL team during #ESC2024. The NUDGE-FLU-2 trial results in Nature Medicine lead by Niklas Dyrby Johansen 👇 Electronic nudges for sustained influenza vaccination uptake in older adults (>65): the nationwide randomized NUDGE-FLU-2 trial nature.com/articles/s4159…

Another simultaneous publication from the great CTCPR Trials & CIRL team. In this specific analysis Katja assessed the relative vaccine effectiveness of HD vs SD in patients with CKD in DANFLU-1. 👇 Published today in JACC Journals Sanofi @BiomedUCPH HerlevGentofte Hosp. RigsHeart 🫀🚨

This year’s CTCPR Trials & CIRL dinner at #ESC2024! We are increasing in size every year; this year was our largest ESC dinner ever (>40 people); including great friends and collaborators like avazir Harriette Van Spall, MD MPH 🇨🇦 Steve Greene Brittany Weber scottdavidsolomon Ankeet S. Bhatt, MD, MBA Sheila Hegde Nochioka Kotaro

New NUDGE-FLU-CHRONIC analysis presented at #ESC2024: Electronic nudge letters ⬆️ vaccine uptake in a broad range of individuals with DM by 9.1% points 💉🦠, but the effect was slightly lower compared to those without DM 🤔 Tor Biering-Sørensen, MD, MSc, MPH, PhD Niklas Dyrby Johansen

New analysis from NUDGE-FLU-CHRONIC at #ESCCongress Letters significantly boosted vacc rates in those with and without CKD, but magnitude of benefit was less for those with CKD. Further strategies should be explored to boost GDMT in CKD including seasonal vacc. Pub soon👀

Congrats to Niklas Dyrby Johansen on a brilliant PhD defense! Leveraging 🇩🇰 Denmark’s digital health infrastructure for pragmatic RCTs with key insights from DANFLU-1 and NUDGE-FLU! 💡📊 Tor Biering-Sørensen, MD, MSc, MPH, PhD CTCPR Trials & CIRL Monster Energy

A remarkable set of nationwide #ImpSci RCTs by Niklas Dyrby Johansen & Tor Biering-Sørensen, MD, MSc, MPH, PhD informing public health messaging to ↑ influenza 💉 at scale! #NUDGEFLU The Lancet: Initial implementation #NUDGEFLU2 Nature Medicine: Sustained implementation #NUDGEFLUCHRONIC JAMA: Younger adults

Prevalence and prognostic implications of undiagnosed T2D in HFpEF 🫀 Our results in JACC:HF based on data from 3 trials: >1 in 20 HFpEF 👫 have undiagnosed T2D! Undiagnosed T2D was assoc with ⬆️ rates of HF 🏥 and ☠️ jacc.org/doi/10.1016/j.… Muthu Vaduganathan JACC Journals

New RSV vaccine RCT! 🚨 This week we started recruitment for the DAN-RSV trial 130.000 👴🧓 60+ years will be randomized 1:1 to RSVpreF vaccine 💉 or no RSV vaccine Prim endpoint: RSV-related resp disease hosp 🏥🦠 Info here: clinicaltrials.gov/study/NCT06684… Tor Biering-Sørensen, MD, MSc, MPH, PhD CTCPR Trials & CIRL

Update on the DAN-RSV trial 🚨🦠🚨 After 1 week of recruitment we have managed to individually randomize 50.000 participants 1:1 to the RSVpreF vaccine 💉 or no RSV vaccine 🚫💉! Read more about the trial here: clinicaltrials.gov/study/NCT06684… Tor Biering-Sørensen, MD, MSc, MPH, PhD CTCPR Trials & CIRL

🚨 DAN-RSV trial update! 🚨 After 2 weeks of inclusion we have now individually randomized >100.000 adults 60 years or above 1:1 to RSVpreF vaccine 💉🦠 or no RSV vaccine 🚫💉. DAN-RSV is an innovative RCT with registry-embedded randomization 💡 Tor Biering-Sørensen, MD, MSc, MPH, PhD CTCPR Trials & CIRL 👇

Excited to kick off day 1 of our annual RCT course at Københavns Uni with Danish Cardiovascular Academy! Caroline Espersen Manan Pareek, MD, MSc, PhD, FAHA, FESC Maria Dons & Niklas Dyrby Johansen will take us through RCT fundamentals and we'll conclude with a trial stats📊masterclass by Brian Claggett from Harvard Medical School Tor Biering-Sørensen, MD, MSc, MPH, PhD