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Excellent lecture by Noa from our lab. Senescent microglia rules the show...

We are deeply saddened by Leonard Hayflick’s passing. His revolutionary discoveries opened new scientific avenues, and his inspirational story will endure. We would like to share the seminar he gave us, detailing the journey behind his groundbreaking work. youtu.be/QYjyceTOLhQ?si…

In a new study published today in Nature Cell Biology, researchers from Prof. Valery Krizhanovsky introduced the possibility of treating age-related diseases by immunotherapy – the same kind of therapy that is currently revolutionizing the treatment of cancer: harnessing the immune

Congrats Julia Magdalena Majewska Amit Agrawal . Thanks Uri Alon for great collaboration.

Aging is a complex process, and one of its hallmarks is the accumulation of senescent cells. These cells, while once healthy, have become damaged and dysfunctional. But why do they stick around? 🤔 Our new research sheds light on this! #aging #senescentcells #aging

Immunotherapy as an anti-aging treatment? Valery Krizhanovsky we show that immune checkpoint anti-PD-L1 can enhance the immune system to remove senescent cells & ameliorate age-related phenotypes! Amit Agrawal Uri Alon IdoAmitLab Weizmann Institute nature.com/articles/s4155…

We show that p16 expressing #SenescentCells enhance PDL1 stability, by downregulating its ubiquitin-dependent proteasomal degradation to accumulate in #Aging and chronic inflammation. Anti-PDL1 activates an immune response to eliminate senescent cells and decrease inflammaging.

Happy to see our latest manuscript on the minimal set of markers to identify senescent cells in vivo out! Big effort with many excellent colleagues cell.com/cell/fulltext/… Demarialab ERIBA Research UMCG

📑: Julia Magdalena Majewska Amit Agrawal et al fr/Valery Krizhanovsky show that p16-expressing senescent cells enhance the stability of the immune checkpoint PD-L1, by downregulating its proteasomal degradation to accumulate in ageing and chronic inflammation. nature.com/articles/s4155…

The business side of academic publishers... The question is what would be a better model?

Immunotherapy a key to fight aging? We break down our recent study in this animation! 🧪 Immune checkpoint anti-PD-L1 can enhance the immune system to remove senescent cells & ameliorate age-related phenotypes! nature.com/articles/s4155…… Julia Magdalena Majewska Valery Krizhanovsky

Incredible program to apply to

Congrats Nurit. In this stidy we show that p21 might be master regulator of cellular microenvironment with a critical role in fibrosis. Thanks to all the coauthors.

Save the date! Marco Demaria announced that the next ICSA meeting will be held in Rome, marking the 10th anniversary of the ICSA meetings. Get ready for #ICSARome2025! 🇮🇹

One very ineresting view on aging clocks and what they can or cannot tell us. 👇 nature.com/articles/s4159…

Very interesting study!

Our new website is up and running!!! weizmann.ac.il/mcb/valery/

Nothing can break us!

It took me more than 10 days before I could enter Ullman and climb to the burnt lab. Heartbreaking. Thankful to Weizmann Institute for helping us get up on our feet and look forward.

How we’re rebuilding the Weizmann Institute — and our hopes for a better future nature.com/articles/d4158…