Why do some patients benefit less than others from precision cancer medicine? We are excited to share our paper "Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling” out in Nature Communications. nature.com/articles/s4146… 🧵

Ready to hear our PIVOTING story? The preprint "Microtubule pivoting driven by spindle elongation rescues polar chromosomes to ensure faithful mitosis" led by Isabella Koprivec and Valentina Stimac is out. Here's a tweetorial for you! biorxiv.org/content/10.110…

Women are born with all their oocytes, which need to stay viable for decades to ensure fertility. How are they maintained for that long? Our latest research in Nature Cell Biology reveals that oocyte maintenance involves exceptional protein longevity. nature.com/articles/s4155… (1/9)

Check out our revised preprint led by Kruno Vukušić, "A kinetochore-centrosome feedback loop linking CENP-E and Aurora kinases controls chromosome biorientation and congression"! biorxiv.org/content/10.110…

Nature research paper: Cellular adaptation to cancer therapy along a resistance continuum go.nature.com/3Wsr7aF

✍️The Dumont Lab published a new article in Nature Communications: Maternal inheritance of functional centrioles in two parthenogenetic nematodes ➡️urlz.fr/rjep

Micronuclei are frequently observed in tumor cells as a result of aberrant chromosomal separation. Two new Science studies investigate the cellular processes involved in micronuclear collapse. Learn more in this week's issue: scim.ag/8bF

Congratulations to all! I am so proud of Tamara, who gets the award for her amazing master thesis.

Woohoo, it's out! Our exciting publication in PNASNews on genetic variants in kinesin genes that alter egg aneuploidy in humans. pnas.org/doi/10.1073/pn…

Excited to share our latest work, just published in PNASNews and led by Patrik Risteski! Check out the highlights in the thread below, and the full text here: pnas.org/doi/10.1073/pn…

#1 Happy to share our last work published in Nature Cell Biology about a new cell cycle checkpoint that senses nuclear shape and mechanics to guarantee genome integrity nature.com/articles/s4155…. Great work from Solène Hervé and Andrea Scelfo in close collaboration with Kate Miroshnikova.

Check out our latest work using the AID2 system to control the levels of an essential protein in mice. Congrats to the entire team, especially @SladkyValentina and Margaret Strong science.org/doi/10.1126/sc…

DON'T FORGET, Virtual Cell Cycle Club!! Tomorrow, TUESDAY, March 4!! 3pm GMT (7am PST, 10am EST, 4pm CEST, 11pm JST) Program: 3 selected talks 1 keynote 4 breakout talks You can still Registration, to attend tomorrow! events.abcam.com/cellcycleclub

Thrilled to be part of this fascinating story! Combining multiplex cell biology, biophysical techniques, and mathematical modeling, we investigate how chromatin biomechanics regulate spindle size across eukaryotic species in both mitosis and meiosis. Check it out!

Amazing energy at our second Swiss-Croatian Bilateral Project meeting with Meraldi lab and Nenad Pavin in Srebreno near Dubrovnik! The labs teamed up instantly, with lots of brainstorming and cool ideas for new joint projects! Croatian Science Foundation Swiss National Science Foundation 🇭🇷🇨🇭

In eLife - the journal: A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei doi.org/10.7554/eLife.…. Out today. If you are at @biomalpar then happy to show the poster on it.

✨Thanks to amazing students @TobiasKletter Sebastian Reusch, postdocs Abin Biswas & collaborators Omar Muñoz Vasily Zaburdaev 🇺🇦 ALMF EMBL Heidelberg ✨ 👉Cytoplasmic material properties control spindle architecture and scaling 👉out today Nature Cell Biology rdcu.be/eqPr8

New pre-print! Ryan Kim et al distinguish the roles of the Spindle Assembly Checkpoint as a surveillance pathway only triggered by mitotic errors vs a mitotic timer that is required in every cell division. biorxiv.org/content/10.110…

Endogenous tagging of BLM and PICH reveal their dynamic localization and functions throughout the cell cycle. New preprint: Mitotic BLM functions are required to maintain genomic stability biorxiv.org/content/10.110…

It was a lot of fun collaborating with Tamara Hamann and Zuzana Storchova to exploit lattice light sheet imaging and explore the dynamics of BLM and PICH throughout the cell cycle. We’ve uncovered exciting insights into BLM’s mitosis-specific role in maintaining genome stability!