Our paper Immunity reveals a human baseline setpoint state (ie, "temperature" under which immune responses are initiated) linked to better responses to flu vaccination resembles cell states induced early and uniquely by the AS03 adjuvant. 1/n

How do chromatin modifications quantitatively impact gene expression? How do sequence variants or combinatorial marks influence relationships? We developed a modular #EpigenomeEditing toolkit to systematically test these Q, published today 🧵… nature.com/articles/s4158…

Super thrilled to share a preprint from the lab biorxiv.org/cgi/content/sh… We found pH regulates the inflammatory response 🔥in #macrophage by controlling BRD4-dependent transcriptional condensates. In my lab led by Zhongyang Wu

Thrilled to share our work investigating the influence of tumor cell ARID1A loss on anti-tumor immunity is now out in Cell ! 🎉🎉

🚨🚨🚨🚨 Our new preprint is out! “Pre-existing stem cell heterogeneity dictates clonal responses to acquisition of cancer driver mutations” 🩸🧫🧪🧬 biorxiv.org/content/10.110… The superteam of Indranil Singh and Dani Fernandez tackled a major unanswered question in HSC bio. 1/

Our latest preprint which is the result of ~8 years of collaboration with the The Human Pancreas Analysis Program - HPAP is now available on bioRxiv. Our work represents the largest existing multiome measurement in pancreatic lymph nodes of humans in health and Type 1 Diabetes: biorxiv.org/content/10.110…

1/12 Check out this paper that came out last week from our pan-monogenic project, which utilizes diverse natural single-gene defects in humans to study and assess the immune health of both patients with disease or those clinically healthy. nature.com/articles/s4159…

🚨𝐇𝐞 𝐋𝐚𝐛 job opportunity UC San Francisco 🚨: I'm hiring TWO postdocs - an experimentalist and a computational biologist. Join us to use cutting-edge single-cell and spatial technologies to unravel the mysteries of human tissues. opportunities.ucsf.edu/content/open-p…

Princeton's new Omenn-Darling Bioengineering Institute (Omenn-Darling Bioengineering Institute) is running multiple faculty searches this year! We are really excited to grow our bioengineering faculty & move into a brand-new building. Postdocs on the market - apply at: puwebp.princeton.edu/AcadHire/apply…

Excited for the Keystone Symposium on T Cell Differentiation in Tissue Microenvironments. #KSTCells25 Submit your abstract by Nov 5th for a chance of being selected for a short talk! Joint meeting w Innate Memory Keystone! keysym.us/KSTCells25

What if you could find out the history of signaling activity in each cell with a single round of imaging? Wouldn't that be incredible? Well, we thought so too. And that's what we set out to achieve with INSCRIBE in our new preprint. Let’s dive in! 🚀🔬 biorxiv.org/content/10.110…

People like QR codes right? Scan this to find out more about the UW BioE opening for Assistant Tenure Track Professor! UW Bioengineering

Calling all faculty candidates (postdocs, Asst Profs, senior grad students) - Apply to UW Bioengineering! Job ad at link below. If you are considering applying and have questions on the ad, please email or DM me. Come join us, UW is amazing! apply.interfolio.com/155240

Second edition of the EMBO workshop on Developmental Timing across species. Second edition organized by Bassem Hassan Margarete Diaz Cuadros @VanderhaeghenP2 and I. #EvoDevoTempo Cool speakers & fun networking activities organizers. More details coming soon. Save the date!

Excited to share my PhD work from RafiAhmedLab. We show how CD8 T cells overcome the inability to predict how long a viral infection will last by making adaptable precursor cells a priori—an elegant strategy for an inherently non-prescient immune system. tinyurl.com/53nrpsa6

Trump's proposal is ILLEGAL & amounts to an indiscriminate funding cut for research centers of all sizes, NOT just Ivies. It will mean shuttering labs across the country, layoffs in red & blue states, & derailing lifesaving research on everything from cancer to opioid addiction.

NIH has announced a cut in the "indirect rate" to 15% across the board, in a move that appears to be retroactive to even existing grants. This is a bloodbath for research institutions throughout the country. Brief explainer for those not in this world: buff.ly/3EtML7D

NIH indirect costs fund the backbone of research: maintaining labs, ensuring safety, and supporting admin work. These are essential for groundbreaking discoveries. Drastic cuts to NIH indirect rates are detrimental to academic biomedical research.

⁦Elon Musk⁩ guess whose catching up fast? Instead of supporting AMERICAN science you want to cripple our thriving biomedical economy

Basic science is inspired by curiosity, accountable to evidence, and subject to peer review. Politics should have no role.