Big news in UK lymphoma world NICE approves for use: Pola-RCHP for IPI 2-5 1L #DLBCL nice.org.uk/guidance/indev… #lymsm #DLBCL

Development of WM National Registry out in BJH 👉Role of ethics, Confidentiality advisory grp, consent, Info governance 👉Ensuring data quality 👉Evolving therapy & outcomes 👉PROMs BSH - Haematology WMUK Shirley D’Sa Dima Jaimal Kothari onlinelibrary.wiley.com/doi/10.1111/bj…

Just out in The Lancet Haematology! Adrian Minson & I articulate the Haematology Peter MacCallum CC & Royal Melbourne approach to TP53-mutated MCL. From the limited data, we propose a rational approach to this high-risk clinical entity, where SoC Rx near universally fails. authors.elsevier.com/a/1gW5d8MsWYC5…

Meet Aila, who will be one at the end of February and has already received 40 units of blood and platelets. She was diagnosed with Acute Myeloid Leukaemia when she was just 5 months old. Read her story here ➡️ bit.ly/3YnDlz8

This #WorldCancerDay, we're shining a light on blood cancer. Why? Because despite being the fifth most common cancer, over 50% of UK adults can’t name a single symptom 🧐

Huge shoutout to the consultants, SAS doctors, nurses, physician associates, allied health professionals, advanced practitioners, and everyone else keeping the service going during the #JuniorDoctorsStrike. Thank you for your support, it’s genuinely appreciated ❤️✊🩺

Re Junior Doctor strikes, the 'if you don't like it, get another job / go elsewhere' crowd need to rapidly learn that doctors are doing exactly that. It's (partly) why you struggle to see a GP, or it takes months to see a specialist. We simply do not have enough of them.

The UK has 3.2 doctors per 1,000 people The 2nd lowest in Europe, and fewer than: 🇦🇹 Austria - 5.5 🇨🇿 Czech Republic - 4.1 🇪🇪 Estonia - 3.5 🇩🇪 Germany - 4.5 🇮🇹 Italy - 4.1 🇱🇹 Lithuania - 4.5 🇪🇸 Spain - 4.6 🇸🇪 Sweden - 4.3 We must improve working conditions before it’s too late

THOUGHT FOR THE DAY: No wonder jnr doctors & nurses don’t feel valued. Not everyone is “feeling poor”equally Bank of England . What gvmnt has done to their pay 👇 is an absolute disgrace RT if u think Steve Barclay Sir Jeremy Hunt MP Rishi Sunak should #PayRestoration & save our NHS

Another brilliant 🧵from the brilliant John Burn-Murdoch Financial Times well worth a read

1/18 THOUGHT for the #Coronation W/E: Our NHS is a "jewel in the crown" of UK. But pay in the NHS has been #RoyallyScrewed 👇 If you want to understand why nurses, junior doctors (& potentially consultants) are striking, start with this graph Short🧵 pls read to end & share/RT

THOUGHT FOR THE DAY: With well over 120 THOUSAND vacancies in the NHS, waiting lists just hit its HIGHEST ever level at >7.33 MILLION Current (& future potential) government need to FIX PAY to fix recruitment & #RETENTION RT if you want Rishi to fix this mess #payrestoration

So hugely deserved Jahanzaib Khwaja 👏👏 A pleasure for us all working with you & a delight to see you & your collaborations flourish 🎉

Will Townsend: Longer FU if glofit in R/R DLBCL: • 40% CMR • DOCR impressive • 18mo PFS if in CR at EOT 66% • CR & DOCR similar in post CAR • use dex as pre-med • MTV predicts response & tox #BSH24

UK real world data Glofitamab Kush Ediri n=74, 17 centres 2023-2024 🔹Short fu (median 4m) but outcomes⬇️ cf trial data 🔹Median 3 prior lines, 65% 4th line 🔹CRS 32% 🔸CMR 25% ORR 46% 🔹Real world: PS diverse, histology incl, higher risk genomic profile BSH - Haematology #BSH24

Dr Ediriwickrema: UK real world glofit data R/R high grade NHL • safe ( < CRS / ICANS cf trial) • more post CAR / worse PS pts • CMR 25% ORR 46% (< trial) • 6mo PFS 66% • ?driven by more post CAR pts #BSH24 #lymsm

PembroWM: A phase II trial to investigate the safety and efficacy of rituximab and pembrolizumab in relapsed/refractory Waldenström's Macroglobulinaemia buff.ly/3MieaKm Jaimal Kothari Toby Eyre Kush Ediri

Well it’s a fond farewell to #ISHL13. Take homes: • Young cHL: cure rates 👍, now need to tailor Rx with TARC & ctDNA • Older cHL: PD1-based the way forward but need to ⬇️ chemo burden to⬆️ tolerability • lots to learn from ctDNA based biology. Here’s to ISHL14!

Fantastic effort from the UK Lymphoma Research Group.

Preview our systematic review and meta-analysis in Blood Advances out now... should assessment of clonal relatedness of CLL and RT-DLBCL be the sole factor for Richter transformation prognostication? TLDR: no! Toby Eyre ashpublications.org/bloodadvances/…