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Excited to share our latest work showing that CD19-CAR T cells undergo exhaustion epigenetic programming in patients! Pre-infusion DNA methylation programs predict post-infusion expansion Stephen Gottschalk Aimee Talleur Ben Youngblood (not on Twitter) cell.com/cell-reports/f…

Excited to share work out of the lab from Wesley, current grad student, and Challice published in Transplantation and Cellular Therapy Journal exploring the impact of disease burden on tisagenlecleucel treatment in B-ALL patients at Johns Hopkins Kimmel Cancer Center and St. Jude with our friends Aimee Talleur Stephen Gottschalk

Check out: ASTCT Spotlight Session: ASTCT/ASGCT Joint Session @ 2022 Tandem Meetings | Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR tandem.confex.com/tandem/2022/me…

#Tandem22 What day is it today? IT’S PEDS DAY!! 🎊🎉🥳👏🏽 come for the cool science all the cool kids are doing The PTCTC Stephen Gottschalk Muna Qayed Jaap J Boelens 🇳🇱🇺🇸 Brandon Triplett Nirali Shah Hemalatha Rangarajan MD https

Preferential expansion of CD8+ CD19-CAR T cells postinfusion and the role of disease burden on outcome in pediatric B-ALL ashpublications.org/bloodadvances/…

St. Jude scientists will discuss research on cellular therapies for pediatric cancer and more at #ASGCT22, including interim results for the first 23 patients treated in the multi-center lentiviral gene therapy clinic trial for X-SCID. ow.ly/f9WJ50J6KJ4

PhD student Matthew Bell will participate in the “CAR T cell Efficacy” session at ASGCT. May 17 he will discuss his work engineering a more effective CAR T cell immunotherapy for solid tumors. Learn more. ow.ly/Q6pO50J6OYV #ASGCT22

Peter Chockley, highlights a critical oversight in CAR development. He shows what can be done to modify the immune synapse towards better function. ⁦SNI NK Meeting⁩ #NK2022

Great collaboration with Paulina Velasquez, Challice Bonifant and the Andreeff lab! Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models frontiersin.org/article/10.338…

Great collaboration with the Velasquez lab!

Great collaboration with Alex Marsons' group and the Krenciute lab!

Really proud of St. Jude Research for recognizing the challenges postdocs face and stepping up their salaries. Now starting at $70k🎉 And lots of amazing labs and mentors, come join us! bit.ly/3B2Ty48

Anyone interested in applying can send their CV to [email protected]. Check out our current openings talent.stjude.org/postdoc/jobs @stjuderesearch

Proud of my grad student Matt Bell, who successfully defended his PhD thesis 'Engineered cytokine signaling enhances CARTs for the treatment of solid' last Friday!! St. Jude Graduate School of Biomedical Sciences St. Jude Research

Excited to share Peter Chockley's work on Synapse-tuned CARs out in Nature Biotech today Nature Biotechnology Stephen Gottschalk St. Jude Research Synapse-tuned CARs enhance immune cell anti-tumor activity | Nature Biotechnology nature.com/articles/s4158…

Proud of Matt Bell who published his graduate work on leucine zipper cytokine receptors today in BME! nature.com/articles/s4155…

Join us for The International Conference on Cellular Immunotherapy in Pediatric Oncology (CIPO) at St. Jude in June 2024. stjude.org/education-trai… St. Jude St. Jude Research ASTCT The PTCTC

Congratulations Shruthi!!!

Excited to share our collaborative work on identifying CART targets for pediatric cancer by exon level expression nature.com/articles/s4146… St. Jude St. Jude Research Nature Portfolio