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🔎 Scientists found that overexpression of pirin inhibited autophagy and promoted #NSCLC proliferation. They also identified pirin and ODC1 as a novel cluster of prognostic biomarkers for NSCLC. 🖨️ Journal of Proteome Research bit.ly/3W646ue

Cool story from the Rajagopal Lab on a new type of airway stem cell…our lungs keep surprising us! nature.com/articles/s4158…

Wondering how neural circuits control allergen-induced airway hyperreactivity? Check out our latest study published on nature rdcu.be/dNmys

🚨𝐇𝐞 𝐋𝐚𝐛 job opportunity UC San Francisco 🚨: I'm hiring TWO postdocs - an experimentalist and a computational biologist. Join us to use cutting-edge single-cell and spatial technologies to unravel the mysteries of human tissues. opportunities.ucsf.edu/content/open-p…

Online Now! Alveolar regeneration by airway secretory-cell-derived p63+ progenitors dlvr.it/TCmmkq #stemcells

Online Now! Inflammation-induced epigenetic imprinting regulates intestinal stem cells dlvr.it/TCmw37 #stemcells

Excited to share this collaborative effort with Dian Yang & Matt Jones, combining Cas9 evolving lineage tracing and spatial techniques to study lung cancer evolution. Great supports from Fei Chen Lab, Jonathan Weissman's Lab & Yosef Lab. biorxiv.org/content/10.110…

Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay dlvr.it/TGrbKH

Now online! The gut-lung axis: Protozoa join the party dlvr.it/THNVxR

Scientists have identified the characteristics of #macrophages in the #DuraMater, revealing their distinct markers and behaviors during homeostasis and autoimmune neuroinflammation in mice. Read more in Science Immunology: scim.ag/4jf89xx

Now online! Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation dlvr.it/THQl0W

In the latest issue! Comparative proteomic landscapes elucidate human preimplantation development and failure dlvr.it/THw79K

Online Now! Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy dlvr.it/THwNV6 #stemcells

In the latest issue! High-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning dlvr.it/THwPXG

Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway. #DevBio elifesciences.org/articles/97268…

Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation dlvr.it/TJP2lt

Decoding aging-dependent regenerative decline across tissues at single-cell resolution hubs.li/Q037Z3bS0 Open stem cell research from Cell Stem Cell.

Decoding aging-dependent regenerative decline across tissues at single-cell resolution hubs.li/Q037YDZy0 Open stem cell research from Cell Stem Cell

We’re living through pretty unusual times, but we’re excited to share good news! Our CRISPRa-programmed #embryo model paper is out! Thanks to our amazing group Gerrald Lodewijk Sayaka Kozuki and collaborators. I hope the community finds this model useful for new discoveries #CRISPR

A baby boy with a devastating genetic disease is thriving after becoming the first known person to receive a bespoke, CRISPR therapy-for-one, designed to correct his specific disease-causing mutation go.nature.com/4j3rb8z