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Most mutagenic DNA lesions are not converted into a mutated DNA bp within a single cell cycle & instead segregate, unrepaired, for multiple cell generations; persisting lesions can produce multiple alternative alleles & thus genetic diversity: nature.com/articles/s4158…

And here it is, #LesionSegregation is in print! Pervasive lesion segregation shapes cancer genome evolution nature.com/articles/s4158… x.com/S_J_Aitken/sta…

There is a new write up of the lesion segregation story in Nature Reviews Cancer, titled "Strands of Evolution": nature.com/articles/s4156… Martin Taylor Sarah Aitken @odom_lab Liver Cancer Evolution Consortium

Thanks, Nature Reviews Cancer, for writing this #ResearchHighlight about our recent #LesionSegregation paper in @nature. "Strands of evolution” nature.com/articles/s4156… Our original paper is here: "Pervasive lesion segregation shapes cancer genome evolution" nature.com/articles/s4158…

New #ResearchHighlight! Sarah Aitken et al. @odom_lab, Martin Taylor used mutagen-induced liver tumours to trace individual strands of DNA to which damage occurred & correlate this with mutational patterns. #TumorEvolution go.nature.com/32jaVfX Cancer at Nature Portfolio Liver Cancer Evolution Consortium

Pervasive lesion segregation shapes cancer genome evolution | Nature. Very nice study in last week’s Nature. From Edinburgh Genomics Clinical Facility, ⁦Edinburgh Genomics⁩, and Taylor/Odom groups in Edinburgh/Cambridge nature.com/articles/s4158…

Tim Aitman An excellent piece of applied genome science from the team at @IGMM (Martin Taylor, Sarah Aitken and others) and great for Edinburgh Genomics to contribute! Javier Santoyo

How do tumors evolve and how are mutations generated during tumorigenesis? Outstanding study by Duncan Odom and colleagues in the #Genomics|Program DKFZ and CRUK Cambridge Institute MRC_HGU shows that strand tracing matters. @nature @odom_lab nature.com/articles/s4158…

#IRBBarcelona researcher Nuria Lopez-Bigas also joins #WorldCancerResearchDay with her 👩‍🔬🧑‍🔬colleagues Sarah Aitken at CRUK Cambridge Institute, Martin Taylor at The University of Edinburgh & Duncan Odom at @odom_lab. Because there are no distances and that we can all make a single team! 🙌 #CancerResearch

Next Thursday 10th of Dec, Dr. Duncan Odom (@odom_lab) from DKFZ will be speaking at our HPC Seminar (PioneerCampus @HelmholtzMunich) starting at 4pm. Hope to see you there! Registration: register.gotowebinar.com/register/26811…

I am pleased to host Sarah Aitken CRUK Cambridge Institute tomorrow (15 Dec) at 1pm Karolinska Institutet shorturl.at/bfz28 presenting her work about "Pervasive lesion segregation shapes cancer genome evolution” nature.com/articles/s4158…

Top research stories of 2020 from CRUK Cambridge Institute - including "Cancer study shows how chemicals cause complex cell mutations" #LesionSegregation Sarah Aitken Craig Anderson Colin Semple Nuria Lopez-Bigas Paul Flicek @odom_lab Martin Taylor MRC_HGU

Today is my first day as a #NewPI MRC_HGU Edinburgh Cancer Research! Thrilled to be driving new and exciting research but like Dr Catherine Crompton slightly underwhelmed by the complete lack of any tangible difference in my working day. #DeskGoals

It’s official, the Aitken lab Aitken Lab is opening this autumn MRC Toxicology Unit Cambridge University. We are exploring how DNA, cells, and tissues are damaged by the world around us, resulting in disease, including cancer. And we’re hiring - please spread the word! aitkenlab.org

Tumour genomes are messy. But unravelling this mess to understand its impact on tumour evolution and how we can exploit it to improve the clinical management of patients is crucial. Our *REVIEW* is out! - with Al onlinelibrary.wiley.com/doi/10.1002/pa… MRC_HGU Cancer Research UK in Scotland

So good to be back IRB Barcelona this week to present new work from Liver Cancer Evolution Consortium, discuss future plans for Aitken Lab, and explore #Barcelona from a new perspective... Thanks for inviting me Nuria Lopez-Bigas and bbglab for sharing your exciting project ideas - a pleasure as always!

WE'RE HIRING A POSTDOC! 🎉 Are you excited to develop and apply statistical and computational methods to disentangle the structural variant landscape in tumours? ewinggroup.github.io/launches/2022/… Apply here: closing date 7th June 5pm elxw.fa.em3.oraclecloud.com/hcmUI/Candidat… 📸 Craig Nicol Institute of Genetics and Cancer

Thank you @CirielloLab and @MagnaniLab_ICL for organising such an interesting, fun, and productive #EMBOcancerEvolution workshop Great to give a preview of #StrandInteractions - our sequel to #LesionSegregation. Now over to Martin Taylor for the full story at GRC #Mutagenesis

Introducing #StrandInteractions - our sequel to #LesionSegregation “Strand-resolved mutagenicity of DNA damage and repair” biorxiv.org/content/10.110… Here’s a #tweetorial on replication, transcription, DNA interactions, and #mutagenicNER...! [1/9]