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bennett.ox.ac.uk/blog/2025/04/t…

"We estimated 20% probability of detecting new treatments with OR > 50 …Increasing the number of RCTs from about 20 to 40 or 60 per year would double or triple the likelihood of detecting breakthrough treatments with dramatic effects.“

Wow. Only 1/5 of trials published in the last 10 years in major journals report patient involvement. Need to do much more here! bmj.com/content/389/bm…

How to write a response to peer reviewers. sciencedirect.com/science/articl…

Just 24 participants to go: Our Swisswide pragmatic #MultiSCRIPT trial is close to reaching 915 in about a year. Only possible through full embedding in routine care and with an outstanding team RC2NB and #SMC and the wonderful support of our patients. multiscript.rc2nb.ch

Breakthrough for #EBM! #GRADE, leading resource for certainty of evidence and evidence to recommendations now too complex, disorganized. Solution in 7 papers on GRADE essentials “Core GRADE” in #BMJ. This week, introduction to series summarizes content. bmj.com/content/389/bm…

You can write clinical trial protocols meeting all formal requirements for regulators and ethic committees that produce zero scientific value. Thats a problem. Clinical study protocols are not primarily regulatory documents.

The GRADE approach is the dominant system of rating certainty of evidence and grading healthcare recommendations worldwide. This article introduces a series of papers on new guidance for the GRADE approach bmj.com/content/389/bm…

A major update to the CONSORT reporting guidance for clinical trials was published last week. 📌 CONSORT 2025 replaces all previous versions and should be used from now on. So what’s new and what’s different? 1/7 #MethodologyMonday #116 (COI - I am a co-author)

#GRADE, indeed #EBM, will never be the same. GRADE papers have become too complex and difficult to navigate. The remedy: a series of 7 papers in the #BMJ laying out the essentials of GRADE: Core GRADE. This week, an overview of Core GRADE. bmj.com/content/389/bm…

This article is the first in a series describing the fundamental points that authors of systematic reviews, health technology assessment reports, and clinical practice guidelines need to use the Core GRADE approach bmj.com/content/389/bm…

I’m proud to welcome Dr. Vinay Prasad, MD, MPH, as the new head of FDA’s Center for Biologics Evaluation & Research. With 500+ peer-reviewed publications and two books, Dr. Prasad brings the kind of scientific rigor, independence, and transparency we need at CBER—a significant

Today in #BMJ, 6th in 7 part series on the essentials of #GRADE – Core GRADE: creating excellent Summary of Findings tables allowing clinicians and guideline developers to easily and comprehensively grasp evidence that will assist patients to make optimal decisions.

Personalized treatment decision algorithms for the clinical application of serum neurofilament light chain in #MultipleSclerosis. A modified Delphi Study from Lars G. Hemkens Jens Kuhle University of Basel RC2NB ▶️ journals.sagepub.com/doi/full/10.11…

A single-page digital recruitment letter increased clinical trial enrollment compared to longer letter formats, with no impact from color schemes. ja.ma/40ga7Wo

Excellent meta-research: A trial within a large trial shows that consent form length impacts recruitment. Please consider too much text can exclude vulnerable groups / We need to rethink consent forms, too much information may harm. jamanetwork.com/journals/jama/…

Thanks Lars G. Hemkens for the positive feedback on our recently published ‘RCT within a large RCT’. We need to randomize to understand how we can improve processes in our society. The link to our ‘RCT within a RCT’ can be found 👇 jamanetwork.com/journals/jama/… CTCPR Trials & CIRL Niklas Dyrby Johansen

Such research has extraordinary return of investment. Funders need to know, consider and implement.

Win Ratio: A Seductive But Potentially Misleading Method for Evaluating Evidence from Clinical Trials | Circulation ahajournals.org/doi/10.1161/CI… This thought-provoking paper critiques the win ratio in a convincingly articulated manner. I'm curious whether the Bayesian approach with

Wonderful quote: “…one of the problems …is that we may think that our customers are grant review panels or maybe…editors,” …“Those may be our short-term customers, but …not … ultimate customers. Our ultimate customers are people who have to make decisions about healthcare”