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Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs? We answer this in our lab’s first paper in nature led by Alex Doan Kat Mueller, PhD Andy Chen. 1/ nature.com/articles/s4158…

Brief Report: Intraventricular CARv3-TEAM-E T Cells in Recurrent Glioblastoma (INCIPIENT study) nej.md/3VnjUIq #Neurology

Most patients diagnosed with glioblastoma die within a year, so innovative therapeutic strategies are needed. An editorial describes the science behind one strategy using a secreting chimeric antigen receptor (CAR) T cell. Read the full editorial: nej.md/49yGoKf

Dr. Christine Lee Christine K Lee will serve as the director of our Endoscopic Skull Base Surgery Program and co-director of skull base surgery at the Norman Prince Neurosciences Institute of Lifespan. Learn more in this interview with PBN pbn-com.cdn.ampproject.org/c/s/pbn.com/fi…

Check out this quick read from SNO on CART studies for #glioblastoma, all published within a few days of each other by our group and colleagues Penn Medicine and City of Hope doi.org/10.1093/neuonc…

A natural killer ligand on activated #Tcells could be a new checkpoint to target in multiple #immune diseases and #cancer, according to new research. Broad Institute The Platten Lab DKFZ 📄: scim.ag/6S5

Now online! Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy dlvr.it/T6cbr6

Excited to share our new review on altered cancer metabolism and implications for next-generation CAR T-cell therapies-- written with Vivasvan Vykunta Gust Vandecandelaere Leland G. Richardson William Curry Bryan D. Choi MD PhD MGH Neurosurgery Full Paper: authors.elsevier.com/a/1j8rTbEXZb8Dd

Researchers Marcela Maus and Bryan Choi at Mass General achieved a breakthrough in glioblastoma treatment using genetically modified T cells, showing dramatic tumor regression. This immunotherapy could revolutionize cancer treatment.

Gliomas with IDH mutations have fewer suppressive myeloid cells, and may set the stage for cell therapy w/ #CARTcells. Awesome work Eric Grewal Leland G. Richardson published yesterday in Clinical Cancer Research MGH Neurosurgery MGB Neurosurgery doi.org/10.1158/1078-0…

A CAR enhancer increases the activity and persistence of CAR T cells go.nature.com/3SuUgj3

.Leonora Balaj Bob Carter MD PhD @SmaheenBatool1 develop an RNA-based Droplet Digital PCR assay to detect key #IDH1 mutation in plasma biopsies from #glioma patients with high sensitivity #CancerResearch Cancer at Nature Portfolio nature.com/articles/s4146…

Two recent phase 1 trials hint that bivalent #CARTcell therapies could overcome persistent barriers in the treatment of #glioblastoma, according to a new Science Translational Medicine Focus. scim.ag/8j2

A huge day for spatial omics of cancer, tracing the precise origin and evolution of 20 types of cancer, many in 3D, in ~2,000 individuals, with 12 publications nature Nature Cancer Nature Medicine Nature Methods Communications Biology Collection nature.com/immersive/d428…

#CARTcells for #DIPG #DMG clinical trial (1st arm) results are out today. Full Tweetorial coming, but first want to share the story of a patient whose #DIPG has disappeared for over 3 years. It is a milestone and moment of hope on a journey filled with so much grief. “There’s a

🔉ARTICLE ONLINE Nature Cancer NOW! 'Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas' ✏️By Bradley Bernstein Brad Bernstein and colleagues 📎nature.com/articles/s4301…

A new technology developed at MIT enables scientists to label proteins across millions of individual cells in fully intact 3D tissues with unprecedented speed, uniformity, and versatility. picower.mit.edu/news/mit-metho… #neuroscience MIT ChemE Dept MIT Science MIT IMES MIT Brain and Cognitive Sciences

Congratulations Rishab Ramapriyan, MD on this momentous day!! Proud of you and your accomplishments!