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Study presented by Dr. Patrick Gauthier at #ISHLT2025: Bulk transcriptomics lacks cell-type resolution, but digital cytometry deconvolution may bridge the gap. In >3,200 EMBs, CIBERSORTx identified distinct immune profiles with strong correlation with molecular rejection states.

Great talk by Dr. Yael Peled Yael Peled on immune checkpoint inhibitors in HTx recipients. Clear, practical take-home messages on balancing cancer treatment and rejection risk. 📌 Sharing a helpful scheme shown during the session. #ISHLT2025 #HeartTransplant #Immunotherapy

May Quilty be associated with rejection and worse prognosis? 579 EMB matched with MMDx:42 non-rejection EMB had Quilty lesions 💠 4×↑rejection MMDx | 7×↑TCMR 💠 ↓ Stress blood flow → microvascular dysfunction 💠 No differences in graft function Andrea Fernandez Valledor, MD #ISHLT2025

Is 1R/1A truly “non-significant”? 454 EMB matched with MMDx. 91 ISHTL ACR 1R/1A 💠1R/1A EMB showed higher dd-cfDNA and GEP scores 💠 4× higher rejection rates on MMDx, mainly ABMR (60%) Andrea Fernandez Valledor, MD #ISHLT2025

In the SHORE registry, 1 in 3 EMBs post-HTx were redundant, performed despite negative dual non-invasive testing (GEP + dd-cfDNA). 📉 Higher EMB rates did not translate into better 1-year survival or graft function. 🧠 Time to rethink simultaneous EMB? #ISHLT2025 Jeff Teuteberg

Dr. Katelynn Madill-Thomsen compares MMDx vs histology in >1,500 EMBs (INTERHEART + Trifecta-Heart): ⬆️ High discordance rate ⚖️ When MMDx and histology disagreed, DSA and dd-cfDNA aligned with MMDx 👉Histology may miss rejection, specially ABMR #ISHLT2025

👑 The king under fire? In the SHORE registry, patients with abnormal DNIT (GEP↑ + dd-cfDNA↑) but negative EMB had worse outcomes, primarily driven by graft dysfunction. 💣 Is it time to dethrone EMB as the gold standard? #ISHLT2025 Nir Uriel, MD MSc

What is the role of #Apixaban in #LVAD? Ian B. Hollis The ISHLT ⭐️Overview of prospective trials w/ no thrombotic events at 6 mo follow up and low bleeding events ⭐️Selection Criteria & Reversal Strategy being key components to consider

In failing Fontan patients with cirrhosis, OHT alone may be enough. In a 24-patient cohort, those with biopsy- or imaging-confirmed cirrhosis had excellent outcomes: ✅ 100% 1,3 and 5 year survival in patients with biopsy-confirmed cirrhosis. #ISHLT2025

Are we all being too picky when it comes to increased LV wall thickness on donor hearts? Perhaps yes. Dr Christian O’Donnell Stanford Medicine presents intriguing insights on how we might refine the process.

Dr.Veli Topkara presents a new renal risk score predicting AKI requiring dialysis after heart transplant. Derived from >15,000 UNOS patients (2018–2024) 🔺High-risk (score >6) → 24% dialysis, ↓ 5-yr graft survival 💡 May help to better individualize risks. #ISHLT2025

Dr. P. Ramirez analyzes outcomes of simultaneous (SHK) vs sequential (KAH) heart-kidney transplant using #UNOS data (1988–2023) 🔹SHK patients had higher risk profiles 🔹KAH showed better survival across all after score-matched analysis Prospective studies are needed #ISHLT2025

III 🧬 Bootcamp - what an enlightening and didactic course by Hospital Universitari Bellvitge | HUB + Health in Code 💡 can't recommend it enought to everyone dealing with #cardiomyopathy patients! 🫀 Gracias y enhorabuena Fernando de Frutos Juan Pablo Ochoa María Valverde Gómez Almudena Amor

❤️ Una mare i un fill. Dues esperes. Dos cors nous. Dues noves vides plenes d’esperança. La Isabel i en Lucas comparteixen molt més que una connexió familiar: comparteixen una mateixa malaltia cardíaca. I tots dos van rebre el regal més gran: un trasplantament de cor a l’HUB.

Do not let your guard down! Can endomyocardial fibrosis relapse after heart transplantation? 📄 Read the case in European Society of Cardiology Journals #CardioTwitter #HeartTransplant #EHJCaseReports Jara Gayan Ordas academic.oup.com/ehjcr/article/…

📅 Save the dates! Join us in Barcelona for the European Mechanical Circulatory Support Summit (EUMS) 2025 🔓 Registration already opened 📝 Abstracts: April 10 – June 29 🚀 Summit begins: September 7 🌐 congresseums.com

Registro Español de Trasplante Cardíaco. XXXIV Informe Oficial de la Sección de Insuficiencia Cardiaca, Trasplante y otras Técnicas de Tratamiento Avanzado de la Sociedad Española de Cardiología (1984-2023) #REC #Aheadofprint Luis Almenar Bonet Manuel Gómez Bueno Marisa Crespo Leiro