Shared and disease-specific pathways in frontotemporal dementia and Alzheimer’s and Parkinson’s diseases nature.com/articles/s4159…

Flip a switch, control cell adhesion! Another #sciArt #preLight features graphical abstracts by Barbora Knotkova and Sonhita Chakraborty and presents the work of Ryosuke Nishimura from the Tony Kanchanawong💫 prelights.biologists.com/highlights/opt…

The #eruption on the #Sundhnúkur crater row is now active only in one crater. The #lava continues to flow eastwards towards #Fagradalsfjall, but lava pools have not formed. #Air quality however remains compromised. ruv.is/english/2025-0…

If you're tired of AI and stuff...we published CRISPR-based protocols that you can actually use to delete alpha-synuclein (~100% efficiency) or knock it into endogenous locus (~53% eff) in cultured neurons: star-protocols.cell.com/protocols/4339

#Volcanic #haze has plagued the south west and other parts of #Iceland for some days. Here's how #Reykjavík looked at the start of the week.

Gone!! Sad time. That's it, the vast majority of the Puffins on the Isle of May have now departed and won't be back until next spring. Read for the blog for the full story: isleofmaynnr.wordpress.com

Under which circumstances do genomic neural networks learn motifs and their interactions?biorxiv.org/content/10.110…

Allosteric and Energetic Remodeling by Protein Domain Extensions by cristina hidalgo-carcedo biorxiv.org/content/10.110…

🔬☀️smURFP is extremely photostable!☀️🔬 A comparison of mEGFP & smURFP photostability when fused to lifeact to image F-actin for 7 min on the Nikon SoRa. doi.org/10.1038/s41467… doi.org/10.1038/nmeth.… #FluorescenceFriday #Microscopy #SuperResolution Nikon Microscope Solutions

I spent 1.5 years at MIT designing a new undergraduate program in Genetic Engineering. One of our theses in designing that program (which I’ll share more about soon; I'm writing a long essay about it) was that undergraduate students could be trained to be excellent genetic

Alzheimer’s disease transcriptional landscape in ex vivo human microglia Nature Neuroscience nature.com/articles/s4159…

Check out the News & Views highlighting this work here: nature.com/articles/s4159…

Have $10M and want to cure some diseases? It costs ~$1B to invent a new medicine…but $10M buys you Project Encore, to see if ANY existing drug might be repurposed for ~100 diseases that have no treatments. Contact me - be a hero for desperate patients! docs.google.com/document/d/1dM…

Several successful medicines prove the principle: correcting protein mislocalization can be life-changing for patients. Pooled technology allows testing for treatments like this at scale!

We are proud to be a founding contributor to lipidinteractome.org, a repository developed by Fikadu G. Tafesse & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime

A new machine learning tool, ProDomino, can predict where two proteins are able to be “fused” together. This seems really useful, in part, because many tools in biotechnology are made by fusing protein domains. So this tool, in principle, will speed up tool creation. Base

Target sequence-conditioned design of peptide binders using masked language modeling: nature.com/articles/s4158…

Brain editing now ‘closer to reality’: the gene-altering tools tackling deadly disorders nature.com/articles/d4158…

Tau uptake by human neurons depends on receptor LRP1 and kinase LRRK2 | The EMBO Journal embopress.org/doi/full/10.10…

All of our neural dynamics tools, software, protocols, datasets, and even hardware plans are now available in one convenient place! Check it out and let us know what you'd like to see next.👇 allenneuraldynamics.org/tools