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Congratulations to Dr. Steven Hahn Fred Hutch Cancer Center Hutch Basic Sciences & affiliate faculty UW Biochemistry on being named a fellow of the American Academy of Microbiology at the ASM His lab studies the machinery of gene transcription bit.ly/3BvCfXU

I’m extremely excited to announce that this August I’ll be starting a lab at the Oklahoma Medical Research Foundation (OMRF) in the Cell Cycle & Cancer Biology Research Program! 1/4

I am happy to share our new preprint reporting a role for the nuclear pore complex in regulating PCNA levels on chromatin. Seattle Children's Fred D. Mast John Aitchison biorxiv.org/content/10.110…

Final form of the preprint👇now out in Science Advances. Please read! science.org/doi/10.1126/sc…

We are recruiting a postdoc in my group @Baloni_lab Purdue College of Health and Human Sciences. To work on exciting projects funded by NIH. Please apply- RT!

Our recent work on Mediator recruitment is out Molecular Cell !! sciencedirect.com/science/articl… Congratulations Rafal Donczew, Linda, Steve!!

Online Now: Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response dlvr.it/Sc6lgW

Broad compatibility between yeast UAS elements and core promoters and identification of promoter elements that determine cofactor specificity biorxiv.org/cgi/content/sh… #bioRxiv

Excited to see my final PhD work published Nature Genetics (rdcu.be/c02lQ)! How does DNA methylation repress genes? Through direct inhibition of transcription factor (TF) binding at the motif OR indirect inhibition via sequence-independent recruitment of MBD proteins? 1/6

Interested in single cell genomics but need help getting started? Check out the full agenda for our Single Cell Genomics Day next Friday (4/7). All talks will be live-streamed (no registration required) at satijalab.org/scgd23

Single-cell or spatial? Our new technology - Slide-tags - allows both in the same experiment, enabling true single-cell multi-modal spatial genomics ➡️ doi.org/10.1101/2023.0…

Transcription pre-initiation complex formation & composition is not as uniform as we thought: StarkLab IMP finds distinct PICs acting at housekeeping vs. developmentally-regulated promoters in Drosophila cells #RefereedPreprint via Review Commons embopress.org/doi/10.15252/e…

🧬🔍Ever wondered which transcription factors control the expression of your favorite gene? We've got you covered, presenting a rich repository on TFs binding and function at the gene level! 📚💡 Dive into the exciting details here: biorxiv.org/content/10.110…

New preprint from our lab: E-E-P massively parallel reporter assay to understand how signals from *two* enhancers are integrated by promoters: doi.org/10.1101/2023.0…

We are excited to host Siqi Liu and Lakshmi Mahendrawada on September 27th 9am PDT to hear about injury repair and transcription factors! Please join us via following link: harvard.zoom.us/webinar/regist…

Our paper on RNAPII-BAF-TF synergy is now out in Nature Genetics! Since publishing the preprint (🧵➡️ tinyurl.com/36jtfraj), we added expt to show that enhanced nucleosome eviction upon stabilization of BAF by RNAPII, assayed by CUT&RUN.ChIP, is ATP-dep. ➡️rdcu.be/dsJPk

1/n) Excited to share our new preprint: Using high-res live embryo imaging we show that transcription factor hubs are localized to new genes when specific DNA binding is perturbed. Hub interaction kinetics at these new sites determine factor occupancy: biorxiv.org/content/10.110…

Honored to see our work highlighted by Fred Hutch Cancer Center and Hutch Basic Sciences. In this study, We mapped the binding and regulatory targets of nearly all yeast transcription factors and found that the classic model often doesn’t hold. Check out the paper here nature.com/articles/s4158…

🧬 Surprising findings from the Hahn Lab at Fred Hutch Cancer Center! Dr. Lakshmi Mahendrawada’s new study shows yeast transcription factors have far less binding overlap than expected—challenging assumptions in #GeneRegulation. 📰 bit.ly/4ipY9Qg 📖 nature: go.nature.com/42zR1wd