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New version of our comparison of transformations for single-cell data is on biorxiv.org/content/10.110… 🥳🎉 We completely revised the paper. Across three benchmarks, we show that, despite its theoretical shortcomings, no transformation consistently outperforms log(y/s + 1) 🤯

Proud to present this work by Lukas PM Kremer, Santiago Cerrizuela et al. from Martin-Villalba Lab and our group:

Happy to share our latest work nature. We studied the remodeling and inflammatory events after human myocardial infarction with single cell and spatial transcriptomics data. 🥳 This is a complete make-over of the first pre-print back in winter 2020: tinyurl.com/5n7sfhd7

Interested in trying out our modifications to the #SingleCell #MultiOmics method used in our latest #preprint below? The modified #scNMTseq protocol spearheaded by Santiago Cerrizuela and Oğuzhan Kaya et al. is now out STAR Protocols: doi.org/10.1016/j.xpro… 🧵1/2

Lukas PM Kremer presenting our latest study on epigenetic features of adult neural stem cells at #TCESRC22 on Sicily 🌅, organized by Brunet Lab and @giacomo_cavalli.

We are thrilled to have been awarded an European Research Council (ERC) synergy grant together with @zenlabpasteur, Simon Anders and @MarciniakGroup labs for #PEPS to perpetuate stemness in the adult #brain DKFZ Uni Heidelberg Institut Pasteur, since 1887 CNRS 🌍 #StemCells #Neuroscience

Our dataset on the cycling and #aging female reproductive tract is now online! biorxiv.org/content/10.110… We did a transcriptomic characterization of 50 cell types from 5 female reproductive tissues in young mice during estrus, pregnancy, and in acyclic old mice. @dkfz #singlecell

🔊We're looking for a #DoctoralResearcher to join our group DKFZ #Heidelberg to work in an exciting project on CD95 signaling in #Cancer. Please see the project description/desired profile below & spread the word to anyone who might be interested! #PhD #AcademicTwitter #Science

We’re thrilled to share how interferon regulates stem cell activation and output in the young and aging brain in EMBO Mol. Medicine! 🥳doi.org/10.15252/emmm.… We combine: ✅Ribo-Seq & phosp-proteome ✅In-vivo scRNA-Seq ✅Mathematical modeling 🧵1/

#Job alert, #AcedemicTwitter! 🔊 We are seeking a highly motivated #phd or #postdoc level #researcher in #bioinformatics #computationalbiology with a strong interest in #neuroscience and #stemcell #biology to join our group DKFZ. Please spread the word! martin-villalba-lab.github.io/jobs.html

PhD and postdoc postions for computational biologists, in the labs of Simon Anders (me) and Martin-Villalba Lab (A. Martin-Villalba): Single-cell omics methods in neurobiology. dkfz.de/en/neurobiolog…

#Job alert! 🚨 Hiring together with Simon Anders ! We are seeking a highly motivated #phd or #postdoc level #researcher in #bioinformatics #computationalbiology with a strong interest in #neuroscience and #stemcell #biology to join our group DKFZ. Please spread the word!

So excited to share my work from the last 3 years 🥳🎉🥳 We developed a new method to analyze multi-condition single-cell data and find differential expression neighborhoods for arbitrary exp. designs. All the details (and some cool diff. geometry) at biorxiv.org/content/10.110…

Joint Statement from German Postdoctoral Networks on the Eckpunktepapier from the BMBF postdocnet.mpg.de/127851/Stateme… with Munich Postdoc Network LeibnizPostDocs Helmholtz Munich PhD & Postdoc | Career Center @FMP_MDC_PDA Postdoc Appreciation Week Germany Sociedad CERFA Rede Apoena AWI Postdoc Team and more. #WissZeitVG #ichbinhanna

We're so excited to share our latest work “Identification of astrocyte-driven pseudolineages reveals clinical stratification and therapeutic targets in #Glioblastoma” spearheaded by Oğuzhan Kaya on the wet & @LCForst on the dry lab as a preprint @Biorxiv biorxiv.org/content/10.110…

.Lukas PM Kremer, Martin-Villalba Lab, Simon Anders and colleagues introduce a data processing approach along with an easy-to-use software tool MethSCAn for scBS-seq data analysis. nature.com/articles/s4159…

An important finding that may lead to new ways of preserving brain health in the future "Astrocytes acquire stem cell function through changes in DNA methylation" nature.com/articles/s4158… nature Martin-Villalba Lab Martin Villalba and colleagues @justsaysinmice open-access

Nature research paper: DNA methylation controls stemness of astrocytes in health and ischaemia go.nature.com/4cO6j2d

🎉 Excited to share our latest study in @nature, showing that DNA🧬 #methylation is key to stemness in the adult #brain: nature.com/articles/s4158… A collaboration with Simon Anders, driven by Lukas PM Kremer and Santiago Cerrizuela. #epigenetics #neuroscience #singlecell. Pre-print summary 🧵👇

After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳 nature.com/articles/s4158… LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space. Some highlights⬇️