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“By identifying & promoting good science, treating authors with decency and respect, and ensuring quality of peer review, editors nurture the reputation and quality of journals.” Read the editorial by LSA’s new Executive Editor Tim Fessenden (timisstuck) life-science-alliance.org/content/8/5/e2…

This study introduces a deep learning-assisted approach for uncovering the intricate, real-time cross-length scale interactions between individual cells and the entire organism in a vertebrate model 中央研究院 Academia Sinica NTU Taiwan life-science-alliance.org/content/8/8/e2…

Pro-inflammatory macrophages are dependent on the xanthine oxidoreductase metabolic enzyme to produce the key inflammatory molecule IL-1beta. Here the authors describe the use of a specific inhibitor that dramatically blunts IL-1beta release life-science-alliance.org/content/8/8/e2…

"Stepping back from the mechanics of publishing, we editors have a front row seat for the advance and fine-tuning of the state of knowledge in biology." Read the editorial by LSA’s new Executive Editor Tim Fessenden (timisstuck) life-science-alliance.org/content/8/5/e2…

Deep learning models link local cellular features with whole-animal growth dynamics in zebrafish 中央研究院 Academia Sinica NTU Taiwan hubs.la/Q03nJ-s10

Did you know that febuxostat, unlike allopurinol, can stop inflammasome assembly and IL-1β release by inhibiting xanthine oxidoreductase? This discovery could change how we approach inflammation-related conditions #Inflammation #Research #HealthInnovation hubs.la/Q03nNxNq0

Bhatia et al. use female nematodes to reveal how the conserved eIF4E-Transporter protein (eIF4ET) plays an unexpected role in promoting translation of cytoskeletal proteins to support days-long storage of arrested oocytes life-science-alliance.org/content/8/8/e2…

Tbx1 is essential for cell adhesion by regulating focal adhesion dynamics, primarily through influencing the disassembly process. life-science-alliance.org/content/8/8/e2…

"Through our work at journals, editors facilitate collective decisions at the core of this evolving state of knowledge. Put another way, editors help biology think." Read the editorial by LSA’s new Executive Editor Tim Fessenden (timisstuck) life-science-alliance.org/content/8/5/e2…

Our June issue has arrived! This issue has 3 papers on virus infection models (HIV, syncytial virus, and adenovirus), new findings on oocyte spindle assembly, and a deep learning model predicting adult fish size from cell shape. Plus more: hubs.la/Q03nWyLM0

This study evaluates mitochondrial imaging in C. elegans during aging, comparing various transgenic constructs for tissue-specific mitochondrial visualization. USC Leonard Davis School of Gerontology @Juri_Kim Naibedya Dutta life-science-alliance.org/content/8/8/e2…

"We rely on the expertise of reviewers...Through these relationships, and on a bedrock of trust, editors serve as shepherds, curators, & advocates for the publication record." Read the editorial by LSA’s new Executive Editor Tim Fessenden timisstuck life-science-alliance.org/content/8/5/e2…

Tbx1 modulates cell spreading via Paxillin signaling pathway and integrin traffiking control. hubs.la/Q03pVjs50

Condensate-forming eIF4ET ensures adequate levels of meiotic proteins to support oocyte storage hubs.la/Q03pVhxb0

Dr. Deepa Subramanyam of BRIC-NCCS gives an overview here of the #research that she and her team published in LifeScienceAlliance recently. Read the article here: life-science-alliance.org/content/8/7/e2… #ResearchPaper #DevelopmentalBiology #StemCells

This study identifies CTBP2 as an oligomerization-dependent bridge between pro-inflammatory transcription factors and co-repressors that balances the expression of inflammatory genes. FranziG Helmholtz Diabetes Center (HDC) CRC 1064 Chromatin Dynamics TU München life-science-alliance.org/content/8/8/e2…

Loss of RalGAP impacts secretion, cell polarity and primary cilium formation, results in pancreatitis and neoplasia development in the pancreas, and promotes mutant Kras-driven tumorigenesis. life-science-alliance.org/content/8/8/e2…

Using cryo-EM, the authors analyze solithromycin-bound ribosomes from resistant strains, revealing interactions that may enhance antibiotic efficacy. life-science-alliance.org/content/8/8/e2…

Lysosomal calcium efflux via TRPML1 drives leukocyte migration by enhancing Lamtor1-MPRIP interaction, and ouabain improves pathogenic inflammation by disrupting Lamtor1's lysosomal localization. life-science-alliance.org/content/8/8/e2…

These findings highlight technical considerations, imaging method standardization, and the utility of C. elegans as a robust model for studying mitochondrial dynamics. USC Leonard Davis School of Gerontology @Juri_Kim Naibedya Dutta hubs.la/Q03qD4yY0