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We had a super productive week at the 2-Photon + Ephys Rig! Excellent teamwork in the Chamberland Lab . Thanks, karthala system for the smooth sailing.

A big crowd gethered at Schenley Plaza in Pittsburgh today as part of the "Stand Up for Science" national rally in response to devastating budget cuts to scientific funding proposed by the Trump administration.

Why do I love this short negative results paper? Distinct neural responses of ventromedial prefrontal cortex-projecting nucleus reuniens neurons during aversive memory extinction | Molecular Brain | Full Text molecularbrain.biomedcentral.com/articles/10.11…

You'd think if you knocked out the endogenous opioid pathway- you'd see a difference in pain response. NOPE .... eLife - the journal: Pain persists in mice lacking both Substance P and CGRPα signaling doi.org/10.7554/eLife.…

A pair of methods papers for studying synapses: DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning Boaz Mohar (@[email protected]) karel svoboda @rhodamine110 Nelson Spruston Eugenio F. Fornasiero HHMI | Janelia Allen Institute nature.com/articles/s4159…

Big fan, but why this? Nature Neuroscience nature.com/neuro/

The veil is off. Cutting NSF Graduate Fellowships by half is a pure attack on science. If you believe in meritocracy, this is it. If you believe in STEM, this is where it starts. If you believe in Making America Great Again, this is what it looks like.

Chronic stress literally destroys the brain by interfering with protein and organelle quality control. Interestingly, acute stress does the opposite. nature.com/articles/s4158…

Wondering if this is the wildest finding I’ve read in 2025 so far.

🧵 Bioinformaticians: Drowning in multiple projects? Here's why context switching is killing your productivity—and how to fix it.

Our new paper is out in Science. What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons. Congrats Jake! science.org/doi/10.1126/sc…

Please see this new publication by Arthur Godino, Marine Salery, and others now online in nature. We show opposite roles for D1 vs D2 dopamine receptor- expressing neurons in ventral hippocampus in controlling approach-avoidance behavior. Friedman Brain Institute rdcu.be/ek2DS

Prefrontal ErbB4-positive interneurons for avoidance: Cell Reports Pleasant read. Classical experimental layout. RNA-Seq > cell Identity > up/down cell manipulation > circuit manipulation > behavioral assessment > rescue cell.com/cell-reports/f…

🚨New paper🚨 Excited to share our latest on nature today: The PIVOT PENALTY in research. nature.com/articles/s4158… More than five years in the making. Key finding: The impact of new research steeply declines the further a researcher moves from their previous work.

Dendritic inhibition terminates plateau potentials in CA1 pyramidal neurons biorxiv.org/content/10.110… #biorxiv_neursci

Very excited about the first manuscript from my post-doc lab Chamberland Lab ! A really fun project with highly impactful findings, particularly for #dendrite physiology and Ca2+. Check it out!

Our first paper to characterize oxytocin receptor expressing neurons in the dorsal endopiriform nucleus as a part of the claustrum complex in mice is out. sciencedirect.com/science/articl…

Fascinating! Sometimes the only positive feedback you need is your own.🐭 Functional Autapses Selectively Form in a Subpopulation of Subicular Pyramidal Cells in Hippocampal Formation jneurosci.org/content/45/27/…

Online now: Dynamic redistribution of AMPA receptors toward memory-related neuronal ensembles in mice barrel cortex during sensory learning dlvr.it/TLqP3B

Black-out drunk, a.k.a induced ethanol hypnosis I love it. eLife - the journal: Mediodorsal thalamic nucleus mediates resistance to ethanol through Cav3.1 T-type Ca2+ regulation of neural activity doi.org/10.7554/eLife.…