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Frederick Nguele Meke defended his thesis on studies of phosphates of regenerating liver (PRLs) and became the first PhD from our lab at Purdue! Congratulations Fred!

Congrats to my very talented bench mate, Margot Meyers!!

Thanks to César Alejandro Urbina-Blanco for the Flash Mob video! It’s in two parts

Cool preprint from Gestwicki Lab on Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibiting Binding to the E3 Ubiquitin Ligase, CHIP biorxiv.org/content/10.110…

Degraders galore

Cool paper from Jack Taunton’s lab on An E3 ligase network that engages GCN1 to promote the degradation of translation factors on stalled ribosomes sciencedirect.com/science/articl…

Science + startups speak different languages. Dan Nomura, seasoned academic & founder Vicinitas Therapeutics, is bilingual. Becky Pferdehirt & I chat with him on a16z #BioEatsWorld about the shift from lab to startup + how industry partnerships fuel innovation. bio-eats-world.simplecast.com/episodes/partn…

Just in time for Nik's flash Virtual ChemBioTalks (inactive account) our lab's first J. Am. Chem. Soc. paper! sCIP custom isobaric chemoproteomics capture reagents. Something for everyone in this paper, new synthesis, FragPipe diagnostic ion mining, new reporters, and cysteine reactive electrophiles.

Our 2023-2024 lab photo! Thankful to be able to work with such a great group of scientists! ⁦College of Chemistry⁩ ⁦UC Berkeley MCB⁩ ⁦Institute for Geographic Information Science⁩

FINALLY a piece of science I’ve been patiently waiting to share is out! Backbone Extension Acyl Rearrangements (BEAR) is the first site-selective, orthogonal method to incorporating extended backbones into full length proteins produced in vivo #NSFfunded biorxiv.org/content/10.110…

The #PTPN2/#PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity | Nature nature.com/articles/s4158…

Excited to give a keynote today on our latest research after the ⁦Purdue Boilermakers⁩ Institute for Drug Discovery Symposium!

BREAKING NEWS The 2023 #NobelPrize in Chemistry has been revised to acknowledge the contribution of Jesse Pinkman to "the promotion of an understanding of synthetic organic chemistry to the general public." This is a first for the Nobel comittee.

A useful resource for teaching #chembio courses (I plan to share it with my class) Improving data quality in chemical biology | Nature Chemical Biology nature.com/articles/s4158…

New paper from our lab by postdoc Seong Ho (Johnny ) Hong on the discovery of a covalent recruiter against the Cullin adapter protein SKP1 for targeted protein degradation applications! biorxiv.org/content/10.110…

New bioRxiv from our lab by Qian Shao on a covalent 14-3-3 molecular glue with the transcription factors YAP and TAZ and using this glue as a 14-3-3 recruiter to sequester nuclear neo-substrates into the cytosol! Thanks to #AppleTreePartners & @themarkfdn

I’m excited to announce that I’ve been selected to be a part of the inaugural class of Berkeley @BioEnginuityHub Fellows! I’m so thankful for this funding and networking opportunity, and I’m excited to see what scientific discoveries and innovations this fellowship can enable!

Super excited to share our story on the the rational design of monovalent degraders using a DCAF16 covalent handle alongside with an amazing postdoc Thang Do Cong !!! Huge thanks to Dan Nomura Ethan Toriki Lauren Orr James Papatzimas and Novartis Science for making this possible!

Don’t miss this pre-print just out led by Melissa Lim at UC Berkeley and colleagues! Covalent DCAF16 handles for monovalent degraders - Congratulations! 🎉

You won’t catch me drinking decaf, but these electrophiles sure love DCAF16! Super excited to share my work on the discovery and optimization of DCAF16-binding electrophilic “handle”, which can convert protein ligands into degraders. Check out our preprint for more.