🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Today in nature, we share our latest paper. We developed an algorithm to predict novel peptides cleaved by proconvertases across all human tissues. Using this method, we identified BRP, a brain-derived anti-obesity peptide. nature.com/articles/s4158…

Isoform usage as a distinct regulatory layer driving nutrient-responsive metabolic adaptation dlvr.it/TJPdxx

Our group NNF Center for Basic Metabolic Research (CBMR) is now driven by an all women workforce (barring Kei), & we are incredibly fortunate to have these (multi)talented, hard working & generous women who support & elevate each other every day! Happy International Women's Day! #WomensDay2025

adiposetissue.org: A knowledge portal integrating clinical and experimental data from human adipose tissue dlvr.it/TJRBCj

Happy to share the final version of our new paper published in Nature Communications describing a novel inducible, tissue specific #PolG mutation mouse model, that provides interesting insights into muscle specific #mitochondria induced stress responses nature.com/articles/s4146…

Lab Sakamoto members at the Metabolism Day #MD25 NNF Center for Basic Metabolic Research (CBMR) Posters were presented by postdocs Joy & Jordana and by PhD students Maria, Hongling, Conchita & research assistant Costanza. #AMPK #TFEB #SIK bsky.app/profile/labsak…

We have a postdoc position available in our team to undertake a UKRI-funded project to develop a new cultured skeletal muscle model for studying glc metabolism and insulin action. jobs.cam.ac.uk/job/50597/ Inst Metabolic Science-Metabolic Research Labs Please RT. Please email if interested.

The Sakamoto group members in action on Metabolism Day #MD25 , a 1 day international conference about energy control and metabolism organized by NNF Center for Basic Metabolic Research (CBMR) , now in its 7th successful year!

New! Online now: Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling dlvr.it/TJX2Zl

First time doing a X-tweetorial on our manuscript, be kind ! Our latest work in Nature Metabolism uncovers a striking role for glycogen accumulation in lung adenocarcinoma (LUAD) using spatial metabolomics & MALDI imaging. A thread 🧵 (1/)

Managing insulin resistance: the forgotten pathophysiological component of type 2 #diabetes thelancet.com/journals/landi… #T2D

We are lucky to have incredible #diversity in our group where we learn about new #cultures, #languages, #traditions & most importantly, food! We did a potluck with traditional cuisines around the world & these scientists are not only brilliant, they have mad culinary skills too!

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research | Nature Metabolism ⁦Nature Metabolism⁩ Great collaboration led by ⁦Satchin Panda⁩ and team! nature.com/articles/s4225…

Wondered how #adipocyte #fat release #lipid via #lipolysis in #fasting, cold exposure? Multi-year @Razanilab effort in Journal of Clinical Investigation by postdoc maven Yu-Sheng Yeh identifies #lysosome lipolysis (LAL) as major way on par with known cytosolic route (ATGL) jci.org/articles/view/…

New! Online now: Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism dlvr.it/TJd12Y

Linoleic acid is the most abundant polyunsaturated fatty acid in the Western-style diet and has been implicated in promoting inflammation and cancer. In Science, researchers report a mechanism by which linoleic acid can activate the mTORC1 protein kinase, which coordinates

A bacterium makes a molecule that kills drug-resistant fungi in an unusual way — by targeting various phospholipid molecules in membranes. go.nature.com/3FHmgwb

Finally the tides are starting to turn!! Cancer isn’t all about DNA mutations, nor even mRNA levels. We launched SyzOnc to map the proteins underlying deadly cancers that are not DNA-driven. journals.plos.org/plosbiology/ar…

A human brain map of mitochondrial respiratory capacity and diversity | Nature nature.com/articles/s4158…

Special thanks to Wageningen University for bringing us today's #ArticleinPress #OpenAccess! Six-hour #hypoxia induced #protein degradation in M. gastrocnemius of 24-day-old mice by activating FOXO1 and suppressing AKT-mTORC1 (Jingyi Song et al.): ow.ly/jz0v50VssYN