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A chemical handle that binds to but does not inhibit USP3... In principle it could serve as a starting point for future USP3-recruiting DUBTACs to rescue targets from proteasomal degradation. Structural Genomics Consortium (SGC) Fun collab. with Rachel Harding and Derek Wilson! bit.ly/41sxlbo

A lay introduction to the @NeuroLibre publishing initiative conp.ca/about-neurolib… Big thank you to Patrick Bermudez, Rachel Harding (Rachel Harding), Estrid Jakobsen (Estrid Jakobsen) and the CONP Communication Committee on putting this together!

Announcing the 5th CACHE challenge. Predict novel antagonists for MCHR1, a GPCR with no structure in the PDB but hundreds of known ligands... Compounds will be tested in Bryan Roth BryanRoth lab at UNC and results published. Apply by Feb 14th. bit.ly/484U7Zi #compchem

Steady progress from uniQure - promising data to end the year - ift.tt/aqYxPHZ

Matthieu Schapira, Rachel Harding and Derek Wilson identified a chemical handle that binds to USP3 without affecting its normal function. This compound provides a foundation for future USP3-recruiting DUBTACs to rescue targets from proteasomal degradation. pubs.acs.org/doi/10.1021/ac…

"A protein implicated in a disease, remains a lock without a key unless a molecule can be found to bind to it and deter its harmful effects". Glad to see The Globe and Mail featuring CACHE Challenges in their piece on AI-guided #drugdiscovery. Conscience theglobeandmail.com/canada/article…

CACHE#1 results are in: bit.ly/48zjBhI. No prior ligand for the target. 1955 compounds predicted by 23 experts. 7 convincingly confirmed experimentally. This is the state-of-the-art. Exploration of modern AI techniques in 6 of the 7 top performing methods. #compchem

A new study demonstrates for the first time the ability of Huntingtin protein to directly bind to RNA species. Read our preprint and learn more about the role of a specific RNA, called NEAT1, in connecting with Huntingtin within cells. 📰 biorxiv.org/content/10.110…

In-depth perspective on the first CACHE challenge in Nature Reviews Drug Discovery nature.com/articles/d4157… #compchem Structural Genomics Consortium (SGC) Conscience

Through #OpenScience collaborations, we make our research outputs available to the scientific community with no strings attached. If you haven't already, check Rachel Harding and Cheryl Arrowsmith last preprint on #Huntingtonsdisease biorxiv.org/content/10.110…

How benchmarking challenges and data in the public domain will guide development in AI-based methods and breakthroughs in #drugdesign on a scale analogous to that seen for protein fold prediction? Matthieu Schapira Rachel Harding Cheryl Arrowsmith Levon nature.com/articles/s4158…

Today is the International Day of #HuntingtonsDiseaseAwareness. Read more about the recent visit of the @huntingtonsc to the SGC. Families saw firsthand the progress of Rachel Harding' group in #HDResearch. ▶️thesgc.org/node/1649788

Now peer-reviewed: rdcu.be/dJ7IY ... and just funded by a 5-year #CIHR grant to see with Francesco Gentile,Rachel Harding,Structural Genomics Consortium (SGC), John Irwin Chemistry and a growing number of chemistry labs what this expanding non-commercial chemistry space can do for hit finding.

We are proud of our very own Rachel Harding! Rachel has been working on #HuntingtonsDisease at SGC-Toronto with a strong ethos of #OpenScience and collaboration. Congratulations, Rachel, on this well-deserved recognition!

A win for Structural Genomics Consortium (SGC)’s Rachel and her scientific and #openscience leadership!

Rachel Harding was recently honored with the HDF Nancy S. Wexler Young Investigator Prize. The foundation has also provided funding to support Dr. Harding's research on the interaction between the Huntingtin protein and HAP40. thesgc.org/news/dr-rachel…

Huntingtin is an RNA binding protein and participates in NEAT1-mediated paraspeckles pubmed.ncbi.nlm.nih.gov/39028820/ Awesome study by Manisha Yadav, Rachel Harding , Mahmoud A. Pouladi , hansenhe and Pearson Labs

We're pleased to welcome Assistant Prof. Rachel Harding (Rachel Harding) to the Department of Pharmaceutical Sciences at UofTPharmacy! Prof. Harding's research aims to unravel the complexities of Huntington’s disease & forge new paths for therapeutics 📖⬇️ pharmacy.utoronto.ca/news-announcem…

We couldn't be prouder of Rachel Harding who joined Leslie Dan Faculty of Pharmacy as an Assistant Professor! Please join us in congratulating Dr. Harding on this remarkable achievement! 📲 thesgc.org/news/dr-rachel…