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Delighted to announce MoPEDE - a great collaboration with Tiwari Lab proving you can measure gene activity in the human brain using mRNA and DNA methylation from the surface of explanted depth electrodes and integrate with neurophysiology! insight.jci.org/articles/view/…

In this study, researchers employed spatial transcriptomics to investigate the tumor architecture and microenvironment of triple-negative breast cancer (TNBC) in 92 patients. Read more: tiwarilab.org/f/spatial-tran… #TiwariLab #journalClub

Our new study with Tiwari Lab is now out in full in JCI Insight! A new way to study gene activity and its links to epileptic networks in the human brain. insight.jci.org/articles/view/…

By using SEEG electrodes from epilepsy patients to gather RNA, DNA & protein data, Tiwari Lab Syddansk Universitet reveals unique molecular profiles tied to brain activity--potentially improving epilepsy diagnosis and treatment... insight.jci.org/articles/view/…

A groundbreaking study from our lab "Pan-cancer drivers of metastasis", led by our PhD student Ryan Lusby, reveals critical insights into the mechanisms driving cancer metastasis-the leading cause of cancer-related deaths. Read more: tiwarilab.org/f/pan-cancer-d… #TiwariLab

This study introduces a comprehensive human neural organoid cell atlas created from 1.7 million cells across 36 single-cell transcriptomic datasets and 26 protocols. Read more: tiwarilab.org/f/an-integrate… #TiwariLab #JournalClub

An interesting study that introduces the General Expression Transformer (GET), an advanced foundation model designed to unravel transcriptional regulation mechanisms across diverse human cell types. Read more: tiwarilab.org/f/a-foundation… #TiwariLab #JournalClub

Souren works on uncovering the molecular mechanisms of a gene marker that seems to be associated with Autism Spectrum Disorder. Youtube link: youtube.com/watch?v=IjHO5y… Read more: tiwarilab.org/f/tiwarilab-so… #TiwariLab

ICYMI: By using SEEG electrodes from epilepsy patients to gather RNA, DNA & protein data, Tiwari Lab Syddansk Universitet reveals unique molecular profiles tied to brain activity--potentially improving epilepsy diagnosis and treatment... insight.jci.org/articles/view/…

This study provides a comprehensive multi-omic atlas of the developing human neocortex, spanning five developmental stages from the first trimester to adolescence. Read more: tiwarilab.org/f/molecular-an… #TiwariLab #JournalClub

This study functionally validated cross-disorder GWAS loci, identifying regulatory variants (emVars) and their target genes using eQTLs and chromatin architecture. Read more: tiwarilab.org/f/massively-pa… #TiwariLab #JournalClub

#SDU and #OUH Celebrate the Launch of the Center for Integrated Multi-Omics in Precision Medicine (#CIMP). Read more: tiwarilab.org/f/sdu-and-ouh-… #TiwariLab

This interesting article presents a novel approach by using CRISPR-Cas9 to knock out over 20,000 genes across human cell lines, creating a genome-wide map of how gene perturbations influence cell morphology. Read More: tiwarilab.org/f/a-genome-wid… #TiwariLab #JournalClub

In this study, the authors found that Rela/NF-κB activation reprogrammed microglia into a pro-inflammatory phenotype, which enhanced antitumor immunity and reduced MBM burden. Read more: tiwarilab.org/f/microglial-r… #TiwariLab #JournalClub

This paper introduces DEPLOY, a deep learning model designed to enhance the diagnosis of central nervous system (CNS) tumors. Accurate diagnosis of CNS tumors is critical for effective treatment... Read more: tiwarilab.org/f/prediction-o… #TiwariLab #JournalClub

The immune checkpoint blockade (ICB) therapies have shifted the treatment paradigm for non-small-cell lung cancer (NSCLC), many patients remain resistant. In this study, the authors integrate scRNA-seq (>200K cells)... Read more: tiwarilab.org/f/multi-omic-p… #TiwariLab #JournalClub

In this study, the authors introduced a novel method—multi-omics single-cell optimal transport (Moscot). Compared to traditional optimal transport (OT) approaches, moscot offers three key technical advancements: multi... Read more: tiwarilab.org/f/mapping-cell… #TiwariLab #JournalClub

This study presents a groundbreaking exploration into the complexities of gene regulation. Utilizing the innovative CAP-SELEX technique, researchers mapped over 58,000 transcription factor (TF) pairs, uncovering... Read more: tiwarilab.org/f/dna-guided-t… #TiwariLab #JournalClub

Brain metastases (BrMs) present a major challenge in cancer treatment, with limited molecular profiling to date. This study applies integrative single-cell RNA sequencing to 108 BrMs and 111 primary tumors across... Read more: tiwarilab.org/f/pan-cancer-h… #TiwariLab #JournalClub

Junior #CancerSymposium 2025 Hosted by the Translational Cancer Hub at #SDU University We were thrilled to welcome bright young minds to the Junior Cancer Symposium — a day filled with inspiring talks, innovative research... Read more: tiwarilab.org/f/junior-cance… #TiwariLab