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.Zhi Li_Immunology KelvinTuong Isaac et al use photoconversion to temporally label tumor-infiltrating lymphocytes, revealing the continuous migration of TCF-1+ T cells btwn the tumor & draining lymphoid tissue bit.ly/3OBixjH WithersLab Clatworthy Lab @Hepworth_Lab

Pleased to have my first publication with Clatworthy Lab out & hopefully many more to come! Read our work in Frontiers - Immunology here: frontiersin.org/article/10.338…

Very excited to share our new work explaining how #antibiotics can lead to life-threatening fungal infections, out today in Cell Host & Microbe! A short thread on the main take-home messages... 1/10 Mihalis Lionakis Jigar V Desai authors.elsevier.com/c/1f3s66t8JEjA…

So great to see this finally out!! Top team Clatworthy Lab Kevin Loudon KelvinTuong Benjamin Stewart iScience journal cell.com/iscience/fullt…

Pleased to see our paper "Photoconvertible tumors to track T cell dynamics" with my former lab WithersLab is featured in a special collection on Mechanisms & Models of Cancer Journal of Experimental Medicine CSHL Meetings See the special collection to accompany the meeting: bit.ly/3SMzRo8

We are thrilled to announce the speaker of our next i3 DKFZ seminar: on November 14th at 4 pm we'll have the honour to host Prof. David Withers from Uni of Birmingham who will talk about a novel strategy to track changes in TIL function upon migration into tumors. Save the date! 🗓️

3 year Post-doctoral position in the Withers Lab at the University of Birmingham Details: edzz.fa.em3.oraclecloud.com/hcmUI/Candidat… For more information and/or informal discussions regarding the post, please contact: [email protected]

We have a post-doc position available focused on intestinal and cancer immunology. Ideal for PhD students soon to submit, who want to work with some cool in vivo models to better understand immune responses. Position advertised on BSI Jobs Board immunology.org/careers/bsi-jo…

1 of 5. We are pleased to present our latest study using our dynamic tumour-labelling models: biorxiv.org/content/10.110…

2 of 5 Building on the approaches published last year (pubmed.ncbi.nlm.nih.gov/35472220/), here we have interrogated what happens to NK cells after tumor entry and for the first time provide a real-time map of their progression to a dysfunctional state.

3 of 5 Key finding #1: Using a combination of photoconversion and scRNA-seq, we show that conventional NK cells rapidly adapt their transcriptome following entry into the tumour, establishing a distinct tumour-retained/resident state in only 48-72 hrs. See Fig 1.

4 of 5 Key finding #2: Validation of transcriptomic changes confirmed really rapid changes in NK cells after tumour entry: upregulation of distinct integrins (e.g. CD49a) and loss of key effector functions (e.g. production of CCL5, IFNg) occurs after only 24hrs. See Fig 2/3.

5 of 5 Key finding #3: Administration of IL15/IL-15ra caused distinct NK tumour resident state that maintained effector functions and appeared to enhance tumour control (Fig 6). Many thanks to all involved, particularly Isaac, Colin Lee, Clatworthy Lab

Great to see these two papers come out together today: nature.com/articles/s4146… nature.com/articles/s4146… Has been such a great collaboration with many groups, particularly the Clatworthy Lab. Congratulations again Colin and Isaac Colin Lee Clatworthy Lab

I am delighted to announce our recent Wellcome DA success with Dr Sophie Acton and Clatworthy Lab. Super exciting opportunity. If interested in joining our team as a post-doc please contact any of us for more info.

Relocating the lab to the Oxford Centre for Immuno-oncology going really well. Such a great research environment. We have new positions available, including this post-doc position: jobs.ac.uk/job/DHZ362/pos… New address is: [email protected] - email to find out more