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Our paper on HIF-1α and mitophagy is out! Cardioprotective adaptation to chronic hypoxia (CH) reduces mitochondrial mass via HIF-1α activated mitophagy to save the heart against ischemia/reperfusion injury. Link: onlinelibrary.wiley.com/doi/10.1111/ap… 1/3

Big congratulations Kristy!!

Just out today in Nature Neuroscience led by Ebrahim Asadollahi & Klaus-Armin Nave MPI for Multidisciplinary Sciences. Pleased to have contributed. Oligodendrocytes break down & burn their fat when glucose is limited to fuel white matter. #Metabolism flexibility always key to survival. nature.com/articles/s4159…

New! Online now: m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1 dlvr.it/TD5z2t

Online now! O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production dlvr.it/TD647T

Adipocyte inflammation is the primary driver of hepatic insulin resistance in a human iPSC-based microphysiological system #MASLD #diabetes Nature Communications nature.com/articles/s4146…

It's World Mitochondrial Disease Week 🌍 Join the global effort to raise awareness through education, fundraising, and advocacy. Find local events and get involved: buff.ly/4gmXy1T #MitochondrialDisease #WorldMitoWeek2024 #mito #science

🎉 Huge congratulations to our team! 🎉 At the PhD Student Conference from Fyziologický ústav AV ČR, we proudly took home the Best Presentation Awards: 1st place to Michal and 2nd place to María! 🥇🥈 Plus, a 3rd Best Poster Award for Habiba! 🏆👏 #PhDLife #ProudLab

The study by Korandová et al shows pathway control ratios of permeabilized PBMCs may serve as a reliable predictor for mitochondrial diseases in patients with Complex I defects. 📚 buff.ly/IN7NqYg Alena Pecinova Eliška Koňaříková Mracek Lab Fyziologický ústav AV ČR 1. lékařská fakulta Univerzity Karlovy VFN Praha