🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Have you ever wondered what the genome looks like through the eyes of a DNA language model? In our newest preprint we use DNA LMs to study nucleotide dependencies in the genome, revealing functional elements, characterizing variants and evaluating DNA LMs tinyurl.com/6wbwjaf4

We are pleased to announce the release of The Protein Design Archive. Our comprehensive database of designed proteins highlights the triumphs and challenges of the field: pragmaticproteindesign.bio.ed.ac.uk/pda/ Preprint:biorxiv.org/content/10.110… Michael Stam Marta Chronowska WoolfsonLab #proteindesign

As part of my recently funded ANR-JCJC grant ANR - Agence nationale de la recherche, I’m looking for a postdoc researcher and an engineer with background in deep learning for protein science. Please contact me if you’re interested. Centre Inria de l'Université de Lorraine Loria

I’m thrilled to announce: at JURA Bio, Inc. we’ve constructed a new kind of generative protein model, which allows us to manufacture its generated designs in the real world at petascale. Paper: static1.squarespace.com/static/66db3a5… Blog: jura.bio/blog/variation…

Excited that CREME (Cis-Regulatory Element Model Explanations) is published in Nature Genetics! Work led by ShToneyan! tl;dr CREME interprets rules of gene regulation learned by genomic deep learning models using carefully designed in silico perturbations. rdcu.be/dT3kq

Exciting new work from Qian Cong's group on predicting human protein interactome. Leveraging new eukaryotic genomes, new RoseTTAFold2 trained on +/- pairs of PPI and large distilled dataset of domain-domain interactions! 🤩 biorxiv.org/content/10.110…

📣 If you are interested in #RNA #Splicing using long or short #RNASeq check out our recent paper on combining and contrasting short and long reads for this genome.cshlp.org/content/early/… - we think there are some important lessons for where/how you invest time/💰 🧐and...

Do you like CALVADOS, but also proteins with folded domains? If yes, check out Fan’s paper on the CALVADOS 3 model Several changes since the first preprint including a new parameter set and the application to changes in folding stability in condensates dx.doi.org/10.1002/pro.51…

You still have a couple of weeks to submit an abstract for our next #LEGO meeting day in Paris! gt-lego.cnrs.fr/animation/lego…

Sören, Giulio & I wrote a short review on the use of machine learning methods to study disordered proteins, with a focus on linking sequences to ensembles (by simulation or generative models; or for design), biophysical properties and biological functions doi.org/10.48550/arXiv…

Happy to share our latest on using Alphafold2 with experimental distance restraints to model protein conformations. Vanderbilt School of Medicine Basic Sciences Vanderbilt Center for Structural Biology Google DeepMind #alphafold biorxiv.org/content/10.110…

nature.com/articles/s4158…

The state of field at the moment ... writing the alphabet in proteins. #rosettacon 🤯

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy Wohlwend, Saro and an amazing team at MIT and Genesis Therapeutics. A thread!

PROTEIN DESIGN COMPETITION ROUND 2 The long awaited results are here -- and they don’t disappoint! 📈 We doubled the number of proteins we tested in our lab from 200 to 400! 🧬 Out of those 400 proteins, 378 expressed (95% expression rate!) 🚀 Out of those 378 expressed

Are you looking forward to 2025 as much as we are? 👀 We just updated our 2025 EMBL Annual Poster to include even more courses and conferences for you to join, so go and have a look! ➡️ s.embl.org/poster-x #EMBLEvents #molecularbiology #lifesciencetraining

Curious about alternative splicing? Kick off the year with our latest review in Current Opinion/Research in Structural Biology! authors.elsevier.com/sd/article/S09…