Mice to men: "You stink!" pubmed.ncbi.nlm.nih.gov/36042309/ "Mice showed aversion to the scent of male experimenters and increased stress susceptibility when handled by male experimenters."

pubmed.ncbi.nlm.nih.gov/36042309/

Just finished an *amazing* conversation with the fabulous Duncan Trussell on the Duncan Trussell Family Hour! Beaming into your alien neural circuitry very soon! 👽👾🍄

'Ariadne emerges as a prototype of a new drug class, non-hallucinogenic 5-HT2A agonists, with considerable therapeutic potential across psychiatric and neurological indications.' pubmed.ncbi.nlm.nih.gov/36521179/ #psychedelics

Ariadne: a mythical princess or a forgotten molecule that can lead us to a new class of psychiatric medicines? We show that Ariadne is a psychoactive, but non-hallucinogenic 5-HT2AR agonist, with relatively low receptor signaling efficacy.pubs.acs.org/doi/10.1021/ac… #Pharmaceutical

WHO Gives 5-MeO-DMT Generic Name: Mebufotenin According to its International Nonproprietary Names for Pharmaceutical Substances (INN) list, the World Health Organisation has given 5-MeO-DMT the nonproprietary name "mebufoteninum". (Image from Proposed INN list)

Great review on #psychedelics psychologytoday.com/us/articles/20…

This paper claims psychedelics induce neuroplasticity via direct activation of the BDNF receptor TrkB nature.com/articles/s4159… Before you reach a conclusion, see our paper Science Signaling; 40K+ compounds were tested, none activates TrkB! science.org/doi/10.1126/sc… #psychedelics

SERTlight, a fluorescent substrate of SERT, enables the visualization of serotonergic neurons without genetic manipulation. It doesn't modulate serotonin/other receptors, providing a new tool for the study of the 5-HT system & therapeutics. J. Am. Chem. Soc. pubs.acs.org/do21/jacs.3c11…

Psychedelic toxins from toads could treat depression and anxiety newscientist.com/article/243007…

Lessons from a Toad Psychedelic about the Role of different Serotonin Receptors in Psychedelic Physiology: nature.com/articles/s4158… Congrats to Audrey and David Lankri in this collab with SamesLab and Scott Russo published in nature

A modified psychedelic found in the venom of a poisonous toad could be an effective treatment option for depression and anxiety, according to a study in mice published in nature. go.nature.com/3WsKtwD

Nature research paper: Structural pharmacology and therapeutic potential of 5-methoxytryptamines go.nature.com/3JSe9M3

Proud to share my latest #research on #psychedelics published with Springer Nature in nature Daniel Wacker SamesLab nature.com/articles/s4158…

Hundreds of thousands of potential psychedelics discovered by docking against predicted and real structures of 5-HT2A #psychedelics "AlphaFold2 structures guide prospective ligand discovery" science.org/doi/10.1126/sc…

לכתבה בוואלה -> healthy.walla.co.il/item/3666743

בקטנה: קרפדות פסיכדליות וגאווה ישראלית. בגדול: מחקר חדש שבין מוביליו חוקר ישראלי, חקר את מנגנון הפעולה של החומר הפסיכדלי 5MeO-DMT, המכונה "בופו", שמקורו בקרפדות. ⬇️ מאת: דנה בר-צבי, ד”ר דוד לנקרי David Lankri Columbia Chemical SamesLab Danasaurus Rex

Rational Design of a Potent Non-Psychedelic 5-MeO-DMT Analogue Antidepressant... The effects of the classic psychedelics depend primarily upon their activity at the serotonin 5HT2A receptor. When a classic psychedelic binds to this receptor subtype, it increases the excitability

Yuuge paper on #psychedelics The structural diversity of psychedelic drug actions revealed nature.com/articles/s4146…

Can’t believe #GRCPsychedelics is happening in two weeks! We reached capacity attendance – sorry we could not accommodate everyone. We look forward to seeing many of you at the meeting. w/ Vlad Vyazovskiy Vidita Vaidya Dr Melissa Herman