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More great talks from early career researchers on nutritional supplements in TB, TB prediction models & lung damage prevention by NAC supplement Universität München NIMR Mbeya [email protected] Makerere University Lung Institute Infection St Andrews TB Trials @ Uni of St Andrews EDCTP Global Health EDCTP3

Honoured to have presented some of our findings from longitudinal BMI assessments and TB. Stay tuned for more coming soon!! Thanks to organisers & presenters for such a lovely and informative conference. See you next year!

Well-characterised longitudinal cohorts and generation of IPDs are pivotal to understand the movement of people across the spectrum of TB. Find out more 👇👇 @KatharinaKranz4 Claire Calderwood Celso Khosa Rishi Gupta thelancet.com/journals/lanmi…

We underline the importance of 1) a time dimension to understand progression/regression, 2) incorporating easily obtainable markers (e.g. CRP, BMI) and novel tests, 3) applying innovative analytical methods (especially those applied in diseases also presenting as a spectum!)

Need to define your TB study populations before knowing how important they are / how to find them / what intervention they need. Totally agree Leyla Larsson Claire Calderwood Rishi Gupta @KatharinaKranz4 thelancet.com/journals/lanmi…

Young people were right at the forefront of designing, delivering, evaluating and disseminating CHIEDZA, a community-based, integrated HIV and sexual and reproductive health programme in Zimbabwe THRU_ZIM chiedza.co.zw #AIDS2024

"Young people are not difficult to engage... we haven't really made (HIV) programmes amenable to the barriers that they are facing" Rashida Abbas Ferrand #AIDS2024

And also had the opportunity to present our findings about HIV testing uptake in the context of CHIEDZA - a youth-friendly, community-based, and integrated SRH and HIV service! A privilege to be here and share these results at #AIDS2024 Rashida Abbas Ferrand THRU_ZIM

Rashida Abbas Ferrand #AIDS2024 RCT weekly vit D/daily calcium vs placebo in 11-19 yr olds with HIV Higher vit d levels but no impact on BMD overall but if vit D deficient (<75 nmol/L), significant BMD improvement Largest trial to date of vit D supplementation in children with HIV!!!!

Vitamin D (20,000iu weekly) and calcium (500mg daily) supplementation improves bone density in adolescents age 11-19 living with HIV in Zambia & Zimbabwe with 25OHD<75 - EDCTP VITALITY trial results presented by Rashida Abbas Ferrand IAC - the International AIDS Conference THRU_ZIM

forms.office.com/r/TK3cDqyDaU Following todays massacre and the non-stop genocide, this is by the *Academic Action Network for Palestine*. Please sign and send to academics colleagues you know and cirulate as wide as you can.

It’s out!! Finally…. 😮‍💨 Adult TB prevalence survey with child MTB infection survey (using QFT) in Karachi 🇵🇰 It’s do-able - so let’s do it!! (📣 all funders) We really do need to understand MTB transmission in different contexts better to ✂️the 🔁 url.uk.m.mimecastprotect.com/s/aYhCCX5WOI0o…

Am beyond thrilled to celebrate Palwasha Yousafzai Khan who has got a distinction in a Masters in Applied Statistics-she is beyond doubt one of the most critical original and brilliant thinkers I have ever come across.The TB world is lucky to have such minds London School of Hygiene & Tropical Medicine

TB-affected households face multiple health risks beyond TB, like HIV, malnutrition, and NCDs. In our study across 3 African countries, 1 in 2 had a TB risk factor & 1 in 5 experienced multimorbidity. Claire Calderwood journals.plos.org/plosmedicine/a…

Claire J. Calderwood and team examine the prevalence of HIV, malnutrition, and non-communicable diseases among households with a member affected by tuberculosis in East and Southern Africa. Claire Calderwood @KatharinaKranz4 @THRU_ZIM LSHTM TB Centre ERASE-TB doi.org/10.1371/journa…

In this correspondence in The Lancet Respiratory Medicine we highlight the challenges of inferring TB preventive therapy effectiveness from observational studies: thelancet.com/journals/lanre… A product of the September TB Journal Club... great forum for discussion James Greenan-Barrett Mahdad Noursadeghi

Turns out - movement along the spectrum is dynamic and heterogeneous! Characterisation of the states with more measures (CRP, etc.) will help provide insights into these patterns 💃 ERASE-TB Edson Marambire Claire Calderwood @KatharinaKranz4 (thx Alberto!! ❤️)

Undernutrition is a key driver of TB accounting for 1/5 cases, but relationship is poorly understood. New sys review of this based on 42 studies (>26 million people) by Matt Saunders et al: papers.ssrn.com/sol3/papers.cf… Rein Houben Rebecca Clark LSHTM TB Centre LSHTM TB Modelling Group St George's, University of London (1752-2024)

Congratulations to Faith R Kandiye, Karlos, and Akanksha Mimi Malhotra for completing their MScs London School of Hygiene & Tropical Medicine, and to Fionah Mundoga for earning her MSc at University of Zimbabwe! 🎓 This amazing milestone deserved a celebration—with cake! 🍰#TeamTHRUZIM

Getting ready to kick-off PROMISE trial in Zimbabwe- the largest trial to date of STI screening to improve pregnancy and birth outcomes -THRU_ZIM London School of Hygiene & Tropical Medicine UK Research and Innovation