LatchBio (@latchbio) 's Twitter Profile
LatchBio

@latchbio

Data Infrastructure for Biology

ID: 1418061200533823488

linkhttps://latch.bio calendar_today22-07-2021 04:12:32

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3,3K Followers

38 Following

Kenny Workman (@kenbwork) 's Twitter Profile Photo

Single cell sequencing is one of biotech’s most powerful molecular microscopes. It gives scientists a window into the biochemical state of individual cells, towards understanding precise mechanisms of disease [1] and basic biological processes [2]. We are well past a decade

Alfredo Andere (@alfredoandere) 's Twitter Profile Photo

Boltz-1 is now available on LatchBio UI and API. Supports single proteins or batches of up to 5,000. Predicts 3D structures (proteins, RNA, DNA, small molecules) & supports modified residues, ligands, and glycans. CASP15 LDDT: 65%. MIT-licensed.

Boltz-1 is now available on LatchBio UI and API. Supports single proteins or batches of up to 5,000. Predicts 3D structures (proteins, RNA, DNA, small molecules) & supports modified residues, ligands, and glycans. CASP15 LDDT: 65%. MIT-licensed.
Alfredo Andere (@alfredoandere) 's Twitter Profile Photo

Curio Trekker and Curio Seeker kits represent some of the most advanced spatial omics technologies out there. We've been following their work for years. Now, Curio Biosciences just announced their new Bioinformatics Portal, powered by LatchBio! This is a huge milestone, months

Kenny Workman (@kenbwork) 's Twitter Profile Photo

What happens when single-cell becomes cheaper, faster and easier? More scientists can access it, existing applications become more powerful and new types of experiments become possible. Innovation in workhorse molecular assays is a necessary lever for progress in biotech.

What happens when single-cell becomes cheaper, faster and easier? 

More scientists can access it, existing applications become more powerful and new types of experiments become possible.

Innovation in workhorse molecular assays is a necessary lever for progress in biotech.
Alfredo Andere (@alfredoandere) 's Twitter Profile Photo

Thrilled to announce the Curio x Latch partnership on Jan 23, 2025 at 10 am PST! Join Curio’s brilliant team—Alecks Kutchma, Bertrand Yeung, and Latch’s own Bronte Kolar—to explore the new Bioinformatics Cloud Portal and how to transition DNAnexus analyses to Latch with zero

Thrilled to announce the Curio x Latch partnership on Jan 23, 2025 at 10 am PST! Join Curio’s brilliant team—Alecks Kutchma, Bertrand Yeung, and Latch’s own Bronte Kolar—to explore the new Bioinformatics Cloud Portal and how to transition DNAnexus analyses to Latch with zero
Kenny Workman (@kenbwork) 's Twitter Profile Photo

Peak calling is important for epigenetics analysis but current tools aren't keeping pace with data generation We're releasing a GPU implementation with ~15X speed up on industry workloads A breakdown of the algorithm steps + benchmarks (1\N):

Peak calling is important for epigenetics analysis but current tools aren't keeping pace with data generation

We're releasing a GPU implementation with ~15X speed up on industry workloads

A breakdown of the algorithm steps + benchmarks (1\N):
AtlasXomics (@atlasxomics) 's Twitter Profile Photo

AtlasXomics is thrilled to see our collaborators at LatchBio accelerate peak calling with a GPU-based MACS rewrite—achieving roughly 15X faster performance! This breakthrough significantly speeds up single-cell and spatial assays, enabling quicker epigenetic insights and

Kenny Workman (@kenbwork) 's Twitter Profile Photo

Most code in biology will run on GPUs over the next decade. Bioinformatics workflows, protein engineering models, virtual cells. Excited to partner with NVIDIA NVIDIA Healthcare to write new tools + consolidate access to existing models / hardware to biotechs across the industry

Most code in biology will run on GPUs over the next decade. Bioinformatics workflows, protein engineering models, virtual cells.

Excited to partner with <a href="/nvidia/">NVIDIA</a> <a href="/NVIDIAHealth/">NVIDIA Healthcare</a>  to write new tools + consolidate access to existing models / hardware to biotechs across the industry
Kenny Workman (@kenbwork) 's Twitter Profile Photo

New single cell tech from Lithuania is expanding into the US. Instead of droplets + microfluidics, Atrandi provides semi-permeable capsules that allow reagents to flow in and out over multi step workflows. Opens the door for single cell multi-omics, functional screens and even

New single cell tech from Lithuania is expanding into the US.

Instead of droplets + microfluidics, Atrandi provides semi-permeable capsules that allow reagents to flow in and out over multi step workflows.

Opens the door for single cell multi-omics, functional screens and even
David K. Yang (@davidkmyang) 's Twitter Profile Photo

Thrilled to announce and lead Atrandi Bio’s $25M Series A, unlocking true single-cell omics through their semi-permeable capsule (SPC) technology—a breakthrough emerging from Lithuania.

Thrilled to announce and lead Atrandi Bio’s $25M Series A, unlocking true single-cell omics through their semi-permeable capsule (SPC) technology—a breakthrough emerging from Lithuania.
Kenny Workman (@kenbwork) 's Twitter Profile Photo

The spatial biology ecosystem is exploding but the landscape is pretty complex. We're releasing a database organizing assays + products. And kicking off a series investigating different branches of the technology tree, starting with sequencing-based transcription:

The spatial biology ecosystem is exploding but the landscape is pretty complex.  

We're releasing a database organizing assays + products.

And kicking off a series investigating different branches of the technology tree, starting with sequencing-based transcription:
Hannah Han Le (@lehannahle) 's Twitter Profile Photo

I spent the past ~4 weeks deep diving into all spatial profiling technologies. The landscape is incredibly fascinating. From a few foundational technologies in the 2010s, we now have more than 20 companies + 41 commercial product offerings today. To help navigate the landscape,

Kenny Workman (@kenbwork) 's Twitter Profile Photo

Imaging-based spatial RNA assays are among the most powerful molecular yardsticks in biotech history. We are in early days: new methods coming online, categories developing, technology refining. Study and know thy tools. Absorb ideas across microscopy, in-situ chemistry, error

Imaging-based spatial RNA assays are among the most powerful molecular yardsticks in biotech history.

We are in early days: new methods coming online, categories developing, technology refining.

Study and know thy tools. Absorb ideas across microscopy, in-situ chemistry, error
Alfredo Andere (@alfredoandere) 's Twitter Profile Photo

Spatial biology has been exploding—and keeping track of the key players and technologies gets complicated. To simplify things, we're presenting a comprehensive map of the 20 companies and 42 products defining spatial biology today. We’ve categorized each product by Imaging or

Spatial biology has been exploding—and keeping track of the key players and technologies gets complicated. To simplify things, we're presenting a comprehensive map of the 20 companies and 42 products defining spatial biology today.

We’ve categorized each product by Imaging or
Kenny Workman (@kenbwork) 's Twitter Profile Photo

Releasing a database covering 14 spatial proteomic methods: exploring the technology tree, history + comparing each by throughput, panel flexibility, tissue type, scan area, cost. To understand where a field is moving, study the details of data generation:

Releasing a database covering 14 spatial proteomic methods: exploring the technology tree, history + comparing each by throughput, panel flexibility, tissue type, scan area, cost.

To understand where a field is moving, study the details of data generation:
Josh Pacini (@joshpacini) 's Twitter Profile Photo

Thanks to our partnership with LatchBio, our customers will have a compliant, secure, and intuitive UI where they can easily use our models, both out of the box and fine-tuned for additional indications and drug modalities.

Alfredo Andere (@alfredoandere) 's Twitter Profile Photo

The single-cell market now includes 61 commercial kits from 17 companies! Hannah Le just mapped the entire single-cell universe, categorized by: - isolation method - chemistry (3’, 5’, full-length) - throughput (hundreds → 5M cells/run) - multi-omics capabilities - FFPE support

The single-cell market now includes 61 commercial kits from 17 companies!

Hannah Le just mapped the entire single-cell universe, categorized by:
- isolation method
- chemistry (3’, 5’, full-length)
- throughput (hundreds → 5M cells/run)
- multi-omics capabilities
- FFPE support
Kenny Workman (@kenbwork) 's Twitter Profile Photo

Spatial biology is the most powerful + data intensive tool in biotech history but ~1TB outputs and fragmented tools make analysis difficult. We built a H5 viewer using AnnData, PMTiles + DuckDB that renders millions of cells, transcripts and tiled high content images in the

Kenny Workman (@kenbwork) 's Twitter Profile Photo

Data is the oil of modern biotech. New tools allow us to model living systems too complex for unaided human cognition. Latch is releasing a new capabilities in data curation + delivery: - 30M observational cell atlas across 150 diseases, 200 tissues, 27 technologies - a