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Interested in sterol transport proteins? Check out our #openaccess review on their structure, function and pharmacology, out now in #Bioorgmedchem as part of the VSI in honor of my mentor Prof. Waldmann MPI Dortmund! Great work by Laura Depta and Thomas Whitmarsh sciencedirect.com/science/articl…

Good morning, everyone! Wishing you a day full of productivity ...and #coffee! 😁*We don't know about you, but we feel straight lines are overrated anyway! 😉🤗☕️ ☕️☕️☕️😁* [Cartoon by ErrantScience = Matthew & @MichelleAReeve]

Check out our new paper on mapping the #oxysterol interactome using thermal proteome profiling, now out in ACS Publications Bio & Med Chem Content ACS Chem Biol! Great work by our fantastic postdoc Cecilia! #lipidtime pubs.acs.org/doi/full/10.10…

New #PhDposition in #medchem #chemicalbiology our lab! The project is related to the study and targeting of sterol transport proteins using chemical tools, funded by European Research Council (ERC). RT appreciated! DTU Chemistry kemi.dtu.dk/omos/jobliste/…

New European Research Council (ERC) funded postdoc position in mass spectrometry-based #proteomics in our lab DTU Chemistry, looking to develop target identification and engagement strategies for modulators of cholesterol homeostasis! Please RT #postdocjobs kemi.dtu.dk/omos/jobliste/…

never forget the scale bar! Tim Stearns when biology meets astronomy: cell vs nebula, centrosome vs dying star! Etienne KLEIN

A new paper from Kevan Shokat and Ziyang Zhang identified a strained β-lactone electrophile that covalently targets a KRAS G12 somatic 2 mutation and acylates the mutant serine to suppress oncogenic signaling.

Mechanism of threonine ADP-ribosylation of F-actin by a Tc #toxin - collaborative work by Stefan Raunser & Oschkinat FMP Berlin & Benjamin Bardiaux Institut Pasteur, since 1887 & Bieling MPI Dortmund #cryoEM 🔗 #NMR published in Nature Communications #actin nature.com/articles/s4146…

Yesterday we said goodbye to Hannah and Sara, our visiting trainees from MPI Dortmund. Thanks for joining us and all the hard work!

Thrilled for our Orpinolide story to see the light of day! Huge thanks to the @georg_e_winter lab, Waldmann lab, Luca Laraia and everyone that contributed Hana Imrichova (Novotna), @FabianFrommelt, Laura Depta, Andrea, Chrysanthi Kagiou, Thomas, Cris Mayor-Ruiz, Superti-Furga Lab and Sonja Sievers! 🧵👇

It was a pleasure to play a part in this cool paper by Marko Cigler @georg_e_winter et al! Great work from Laura Depta in our lab who developed an FP assay to determine inhibition of OSBP and ORPs! Watch this space for another joint paper coming very soon!

We have two open #Postdoc positions in #ProteinExpression and #Structuralbiology at the TU Dortmund ! More information here: rauh-lab.de/news-events-re…

New preprint! We discovered potent and selective OSBP inhibitors which inhibit retrograde trafficking by causing partial Golgi degradation. Great work by Nianzhe, Laura Depta, Cecilia, Oliver and Joseph Hoock from our lab! 1/ biorxiv.org/content/10.110…

By building a sterol transport protein (STP) screening set, we identified OSBP as the target of our compounds. They are selective over ORP4, as well as over all tested STPs! The compounds led to inhibition of retrograde trafficking and attenuated shiga toxin toxicity! /fin

New preprint! We discovered degraders and stabilizers of the #cholesterol biosynthesis enzyme squalene synthase, based on the same scaffold! Great work by PhD student Joseph Hoock, with support from Cecilia, Laura Depta and collaborators Mesut and Christianson Lab! biorxiv.org/content/10.110…

My first preprint is out now! We targeted squalene synthase, an important enzyme for #cholesterol biosynthesis and identified small molecule degraders and stabilizers. Grateful for guidance by Luca Laraia 🙏 big thanks to Cecilia, Laura Depta, Christianson Lab and Mesut!

We are using organoid-based disease models to discover new chemical tool compounds to study metabolism in cancer and the gut. These "mini-organs" closely resemble the human organ/disease and allow us to study the disease-relevant chemical space. 1/2

Check out our new paper in J Med Chem ACS Publications Bio & Med Chem Content on the synthesis diverse alkaloid-inspired compounds leading to the identification of 5-HT2A agonists and dual 5-HT2B/C antagonists! Big congratulations to Ruwei! DTU Chemistry 1/n pubs.acs.org/doi/full/10.10…