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Happy to share Bryan W Jenkins 🧠 latest work published in @Psychopharm: Cannabidiol (CBD) potentiates physiological and behavioral markers of hypothalamic–pituitary–adrenal (HPA) axis responsivity in female and male mice link.springer.com/article/10.100… Amy Newman (she/her) The Lab of NODD collab

Excited to share our latest on ELFN1 mechanisms, a dysfunction of which leads to a devastating neurodevelopmental disorder. Swan song of Henry A. Dunn. #GPCR , #Elfn1, Journal of Biological Chemistry sciencedirect.com/science/articl…

Sex-specific neural circuits underlie shifting social preferences for male or female interaction among mice, a new Science study finds. The results offer a clearer picture of the underlying biology of socio-sexual preferences. 📄: scim.ag/4jaVjA3 #SciencePerspective:

Officially moved to UofA! Setting up the lab (thankfully learned my mistakes from the last “new PI” stage!) Hiring, hiring, hiring!! Know folks interested in behavioral neuro, ephys, genetics, opto/chemo, early life stress, fear, reward, & the like? Plz let them know I’m hiring!!

Much-needed good news 🎉: I am honored to receive the ASPET Molecular Pharmacology Division Early Career Award. Big thanks to Mikel Garcia-Marcos Laboratory for the nomination. I am very grateful for the support and recognition by my colleagues at ASPET and beyond. Duke Pharmacology & Cancer Biology Department ow.ly/nYiB50UNQLF

Why do some heavy drinkers keep choosing alcohol over other rewards, even when it costs them? An interesting paper from the Heilig Lab looks into how drinking severity influences choice when alcohol competes with natural reward.

I am proud to share this new review on The Biology of Addiction that appeared today in Science Signaling. It was fun to write the review all by myself and reflect on the tremendous progress achieved over the past three decades...

It's clear that many do not understand what NIH-funded research does to improve health. It's time to revive a study published 10 years ago that provides incredible information about this. link in the comment Every single new drug approved by the FDA from 2010–2016 was built on

A cannabinoid bitopic, biased and peripheral agonist analgesic with limited tolerance and tetrad in Nature. Work led by Vipin Rangari with Rob Gereau Dror Lab kaavya Krishna Kumar Center for Clinical Pharmacology WashU Medicine Anesthesiology A short thread nature.com/articles/s4158…

Join us for the @ClinicPharmSTL Research Seminar featuring Lauren Slosky from UMN Pharmacology and MPaT. Details ⬇️ 📆 Thursday, March 13 ⏰ 1-2 p.m. 📍 UHSP Academic and Research Building room 449 anesthesiology.wustl.edu/events/event/c…

Our latest on GPCR function in the brain. We report that glutamate receptor mGlu4 needs to be properly positioned at synapses of cholinergic interneurons in NAc by cell adhesion molecule ELFN1 to regulate opioid reward. pnas.org/doi/epub/10.10…

Had a blast speaking and catching up w/Nicole Scheff, ⚡️GREG_CORDER⚡️ Rob Gereau Lauren Slosky et al at the Center for Adv Pain Ther and Res (CAPToR) UFresearch. Thank you Dr. Rajesh Khanna of the KhannaLabUF and May Khanna for hosting us.

🧠🐭📊🔬🧬BIG PREPRINT UPDATES: Mimicking opioid analgesia in cortical pain circuits We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with our synthetic opioid gene therapy biorxiv.org/content/10.1... 1/15🧵

Excited to share work led by Preston Anderson and Peng Xiao in collaboration with Jinpeng Sun (just like old times when we were postdocs in Lefko lab). We find that beta-arrestins form biomolecular condensates to regulate GPCR function - biorxiv.org/content/10.110…

It finally happened, the Castro lab's first paper! Congrats to Dr. Kathryn Braden!! In this review we examine what we know, and more importantly, what we DON'T know about neuropeptides in the dorsal raphe/ventromedial PAG. Here we go! frontiersin.org/journals/behav…

New leaked document shows HHS wants to merge NIAAA, NIDA, and NIMH into a new "National Institute on Behavioral Health." No budget has been proposed yet, but with a potential 40% cut to NIH and no dedicated addiction institute or director, addiction research is at serious risk

We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It is a simple hack which we hope to be broadly useful. Work by talented graduate student Chuanping Zhao. nature.com/articles/s4146…

Please chk out the lab's newest paper, a labor of love it was. From Andrew Luskin & Li Li, MD, PhD, w/ @madisonmartin Brain in a jar Rhiana C Simon, PhD @GoldenNeuron Stuber Lab & others. We report a new road map for the LC-NE & peri-LC systems. Thx National Institute of Mental Health (NIMH) NIDAnews nature.com/articles/s4158…

Our GzESTY paper is online. We optimized a cell based assay to sensitively detect GPCR activation in response to ligand application or in complex mixtures containing endogenous ligands. GzESTY was designed to aid in GPCR deorphanization efforts. nature.com/articles/s4146…

Excited to present our preprint on the structure-function relationship of anaphylatoxin complement receptors. A casual number of 19 structures deciphering ligand recognition mechanisms, G protein/arrestin and species specific signaling. Check it out! biorxiv.org/content/biorxi…