FleX Fridays [a series of posts about our journey towards taming that best of an instrument that is the #timsTOFFleXMALDI2] | Episode 1: "The Goldilocks Approach to Matrix Spraying" - by Ying, Seth Malloy, @HistomanSIMR.

FleX Fridays [correction to typo/Freudian slip in previous post: "beast" of an instrument" not "best"] | Episode 2: "Early Laser Catches the Worm" - by Cassandra Kempf, Charles B., Ekasit Sonpho (Program), Seth Malloy, @HistomanSIMR

Exploring a new technology that allow scientists to appreciate the spatial information at the proteomic level from a thin tissue slide. Good collaboration between A. Sánchez Alvarado and System Mass Spectrometry (former name, Proteomics), plus Histology core at Stowers Institute

"in vivo" XLMS | Ying presented her latest results on maximizing the number of crosslinked peptides/proteins recovered from whole cell extracts today at #CRC22 Stowers Institute Stowers Crossroads

#FleXFridays | Episode 3: "A leopard never changes its spots"... but a #timsTOFFleXMALDI2 laser does! Cassandra Kempf, @jmvarberg and Charles B. from Stowers Institute have been figuring out what the non-obvious (for MSI newbies) laser beam parameters mean in timsControl & Fleximaging.

2 weeks left to submit your manuscripts for the 3rd Biennial Special Issue on Software Tools and Resources.  Deadline: Sept. 30!  Details here: go.acs.org/2cz

Voice Overs | Finalizing our team's video presentation for Stowers Institute #TechEDGE Symposium next week. A lot of😂from all, some 😭 (mostly me), and a few🤬(all me). Cassandra Kempf Ying @jmvarberg

#FleXFridays | Episode 7: « The Cloud Shape Game ». Some ion images from last week scan on #timsTOFFleXMALDI2. I see a dog’s head, what do you see? Ying Seth Malloy @HistomanSIMR Stowers Institute

Happy 20th (!) birthday Malaria genome & proteome! ⁦@JohnRYatesIII⁩ ⁦@[email protected]⁩

Get into the Groove | Mass spec lab shut down last week to replace 3 old UPS stacks with a new one (6 levels below) and finalize the timsTOF FleX alcove, including a custom recessed ceiling "groove". Thanks Stowers Institute Technical Services and Ops teams.

How do RNA-binding proteins with widespread sequence preference regulate specific transcripts? Another paper from Jerry Workman group Stowers Institute highlights that transcription and epigenetic regulators may hold the key. Congrats @DivyaReddy_2021 embopress.org/doi/full/10.15…

Our new preprint on nucleolar stress caused by anticancer drugs with Jay Unruh, Julie Conkright-Fincham, PhD , Charles Banks, David Schneider, Laurence Florens and Jennifer Gerton is up. biorxiv.org/cgi/content/sh… 🧵

Can confirm! Directly submit to Journal of Proteome Research from bioRxiv starting today! 🥳

The Methods for Omics: Proteome Research and Beyond Special Issue is now online! Mass spectrometry-based technologies included in this issue span topics such as multiomics integration, deep quantitative proteomics, and more. go.acs.org/4Pq

Finally out! Thanks to a great team of friends and collaborators - Proteome-Wide Identification of RNA-dependent proteins and an emerging role for RNAs in Plasmodium falciparum protein complexes | Nature Communications nature.com/articles/s4146…

Great job Xingyu Liu ! An integrated structural model of the DNA damage-responsive H3K4me3 binding WDR76:SPIN1 complex with the nucleosome | PNAS pnas.org/doi/10.1073/pn…