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Chronification of tension-type #headache involves sensitization of #spinal and supraspinal #neurons, and decreased antinociceptive activity from the brain go.nature.com/2Pn2VpU

These 4 panels accurately depict 95% of all biochemistry lab work 🧪

Can green light relieve pain? Multiple teams working on the job now😃! @IbrahimLabUofA, Dr. Rami Burstein, @YukihikoTakemura_KanagawaUni

Finally out! VEGF and Alzheimer's disease! sciencedirect.com/science/articl…

In a controversial decision that shocked some experts, the U.S. Food and Drug Administration overruled a group of advisers to conclude that the Alzheimer’s drug aducanumab deserved market approval. fcld.ly/a37vens

Our lab has finally boarded the preprint train! Check out Annemarie Dedek's thesis work identifying sexual dimorphism in a core spinal mechanism of chronic pain in rats and humans. Another example of the urgent need to include SABV in all of our research. biorxiv.org/content/10.110…

Same for those testing “analgesics” in the light phase on their sleepy mice ... “oh it’s sleeping w eyes closed, just poke it a little first then test” 🙄

Super interesting article! Next journal club ⁦Lisa Boinon⁩?? ⁦Aubin Moutal⁩? A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength. qxmd.com/r/34348149

Weaponized somatostatin-like toxin from cone snail with novel hunting strategy shows analgesia in mice. Great collaboration covering behavioral biology, biochemistry, molecular pharmacology, in vivo physiology. #ConeSnails #Conotoxins Iris Bea Ramiro @WaldenSciencing @BraunerOsborne

Brain circuits for pain and its treatment science.org/doi/10.1126/sc…

Pain: Why sex matters doi.org/10.7554/eLife.…

youtu.be/J7GY1Xg6X20

Gotta love reviews

📢New findings in PAIN Journal on the clinically validated peptide Contulakin-G from the Patwardhan & @KhannaLabNYU labs. Conotoxin contulakin-G engages a neurotensin receptor 2/R-type Ca channel (Cav2.3) pathway to mediate spinal antinociception pubmed.ncbi.nlm.nih.gov/35050960/