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How do LINE family retrotransposons jump around? Can we reprogram retrotransposons? What does this have to do with Rum and Raisin? Answers here and below!

Launch attempt tomorrow

Liftoff of Starship!

Everyone who chooses the path of evil destroys himself. Who sends columns of troops to destroy the lives of another country and cannot stop them from fleeing and betraying when life resists. Who terrorizes with missiles, and when they are shot down, humiliates himself to receive

Check out our preprint on YeastIT, a new system for continuous evolution, addressing the challenge of biased mutational spectra and exploring the long-term evolutionary outcomes of different mutagenesis methods! biorxiv.org/content/10.110… Hollfelder Lab Matt Penner Philipp Knyphausen

What if we could inducibly create thousands of structural variants and ecDNAs in human cells and see which ones survive? biorxiv.org/content/10.110… I’m excited to share our story on scrambling the human genome by combining prime editing, repetitive elements, and recombinases. A🧵

Just shared at Keystone Symposia a new @ArcInstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts

science.org/doi/10.1126/sc… We look forward to working with our scientific colleagues to optimize and expand the application potential and scenarios of HYER, a new nucleic acid manipulation platform. RNA is amazing!

We are happy to share our latest long-range, programmable mutagenesis toolbox - the Helicase-Assisted Continous Editing (HACE) system - to achieve target-specific mutagenesis of the endogenous genome. (1/11) biorxiv.org/content/10.110…

Making vacuum vessels for our fusion systems!

Today starts a new era of genome engineering! We use RNA-only delivery to safely and efficiently deliver genes of interest to the human genome! Collins Lab UC Berkeley MCB A thread 🧵: nature.com/articles/s4158…

This is so cool! Synthetic G protein-coupled receptors for programmable sensing and control of cell behavior biorxiv.org/content/10.110…

Clean Energy Futures Under Construction ☀️ This is the heart of the Commonwealth Fusion SPARC reactor in Devans, MA. Magnetic fusion will help power the 10x growth in electricity needed by 2030 for AI data centers and EVs, with emission-free energy. After slipping through a

Slow motion liftoff of Starship on Flight 4

A Nature Biotechnology article by Hollfelder Lab, James Thaventhiran, markohyvonen bsky social, Cambridge Department of Medicine, Oxford Protein Informatics Group (OPIG) establishes new technology for finding therapeutic antibodies in response to infectious disease outbreaks faster, using anti-covid reagents as a showcase: bioc.cam.ac.uk/news/new-techn…

I'm going on the record as a Protein World believer. Origins of life: The Protein Folding Problem all over again? | PNAS pnas.org/doi/10.1073/pn…

Published today in nature, we describe an approach for single-molecule protein reading on Oxford Nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. nature.com/articles/s4158…

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. Djenet Bousbaine led the charge... nature 1/55

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis

We’re excited to share new work on the continuous in vivo evolution of gene libraries towards arbitrary functions. Led by superstar Olek Pisera, our experiments show that gene evolution is highly versatile...biorxiv.org/content/10.110…