A new paper from Ivan Ahel Lab about enzymes that efficiently ubiquitylate DNA and RNA in vitro and maybe in cells. With contribution from Orléans by vincent aucagne and a little bit myself. Part of a larger project on noncanonical Ub by DELTEX E3 ligases led by Kang Zhu as the 1st author.

A big day of output for the Human Cell Atlas, a global collaborative project with 100 countries to understand our ~37 trillion cells A Wikipedia of our cells, a "remarkable achievement" nature.com/articles/d4158… nature.com/immersive/d428…

Online Now: Elucidating acquired PARP inhibitor resistance in advanced prostate cancer dlvr.it/TGK8cc

Light-activated catalysts can degrade "forever chemicals" go.nature.com/4fAgGZr

Amazing talk by Thanja Lamberts at the #ReedijkSymposium. She talked about her work in the field of astrochemistry and the importance of surface chemistry, low temperature, low density, element availability, timescales and telescopes for her research. pubs.acs.org/doi/10.1021/ac…

Great talk by Sebastian Geibel at the #ReedijkSymposium. He talked about his group’s work on mycobacterial type VII secretion systems and their study using biochemical and structural biology methods. nature.com/articles/s4158…

Sebastian Geibel Sebastian Geibel represented the LED3hub at the #ReedijkSymposium. He talked about the importance of keeping up research into new treatments for tuberculosis and about his research into the mycobacterial type VII secretion systems as a potential drug target.

Interesting keynote lecture by Herma Cuppen at the #ReedijkSymposium. She talked about her group’s integrated experimental and theoretical work on jumping crystals based on organic materials that undergo a thermal or photodriven phase transition. nature.com/articles/s4146…

The #ReedijkSymposium of the Leiden Institute of Chemistry was an amazing event. I had a great day and learned a lot at the talks and the posters. Thank you to all participants and especially to the organizers Irene Groot, @BonnetSylvestre and Yvonne Snellenberg.

Our laboratory is looking for a postdoc with expertise in protein biochemistry and structural biology to work on novel pathways regulated by ADP-ribosylation of nucleic acids. Please RT.

If you are a young PI in Chemistry or a related discipline and want to connect to a vibrant network in the Netherlands, join the #NextGenChemNL Symposium 2025 in Enschede on June 19th and 20th. You can sign up for the newsletter to not miss anything: docs.google.com/forms/d/e/1FAI…

Een belangrijk artikel van de "Antimicrobial Resistance Collaborators" in The Lancet. Een voorspelling die in 2050 >8 miljoen sterfgevallen als gevolg van antimicrobiële resistentie voorspelt, maar ook een sterke daling als we investeren in betere zorg en nieuwe antibiotica.

Amazing talk by Marthe Walvoort at #NWOCHAINS2024 in front of a full house. She talked about her group's exciting work on the isolation of polysaccharides of bacteria as well as the synthesis of probes to better understand their role in health and disease. pubs.rsc.org/en/content/art…

Excited to see Julia Pols presenting their research in our group at #NWOCHAINS2024. They did a great job in giving a clear presentation on their PhD project on identifying new ligandable cysteines as antibacterial targets against MRSA. #proudPI #ChemBio #Antibiotics

The poster sessions are a highlight of #NWOCHAINS2024 but it is hard to get to all of them. The poster pitches were a great way to get a quick overview of the diverse topics including the research by Sean McKenna of LED3 hub (inactive account) on using "Active Learning for CCR2 inhibitor discovery"

We have a new article out in collaboration with MVermeulenLab ! Photoaffinity probes based on Olaparib for Proteomic profiling. Simple but powerful! 💪 Read here: …mistry-europe.onlinelibrary.wiley.com/doi/abs/10.100…

🥳 Out now The EMBO Journal! Interferon induces a new class of p62 bodies, with antiviral & immunotherapy implications. p62 is usually linked to autophagy—but not here. These are driven by PARP14-mediated ADP-ribosylation & rely on ubiquitin-proteasome system. embopress.org/doi/full/10.10…

Why it matters 👇 p62 bodies are key hubs for protein degradation & immune signaling—long linked to cancer & neurodegeneration. Our study shows interferon + PARP14-driven ADP-ribosylation rewires their formation, revealing a new immune-regulated condensate class.

For #condensate folks 👀 Our study tackles a key gap: how condensate composition is regulated. These p62 bodies require PARP14—but it’s not just presence that matters. It’s PARP14’s enzymatic activity that drives formation. In fact, more PARP14 without activity ≠ condensation.

Orthogonal Site-Specific Dual Bioconjugation of Aryl and Alkyl Thiols | Journal of the American Chemical Society Humboldt-Universität zu Berlin FMP Berlin pubs.acs.org/doi/10.1021/ja…