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The dual capacity for cancers to metastasize and resist systemic treatment is the tipping point for driving lethal cancer. Drs. Pienta, Goodin & Amend explore how eco-evolutionary principles can guide new interventions: acsjournals.onlinelibrary.wiley.com/doi/full/10.33… Kenneth Pienta Sarah R. Amend, Ph.D. OncoAlert

Cancer of Unknown Primary NEJM-2025 ▫️CUP 1–3% of cancers ⚠️Subtypes: favorable (20%) vs unfavorable (80%). Molecular profiling identifies origin in ~30% & actionable mutations in ~40%. ICIs for TMB/MSI/PD-L1+ An excellent review, a must read! OncoAlert nejm.org/doi/full/10.10…

#ASCO25 Anne Schuckman discussed how to navigate the crossroads and the evolving treatment paradigms in the Perioperative Management of MIBC: 💉 NAC + RC remains standard, but NIAGARA & others push toward IO combos 📉 BCAN survey: only 1/2 of pts saw a MO and 1-5% discuss TMT

The most practice changing trial from #ASCO25 is now live on NEJM .If this was a drug, this would be approved today. Globally relevant and low-cost intervention that is not only delaying relapse but actually improving survival. Perfect case example of a #cancergroundshot trial.

Early-career surgeons face high vulnerability to moral injury from complications and poor outcomes. Building “protective equity” through mentorship and peer support may mitigate long-term harm. journals.lww.com/annalsofsurger…

This AI for systematic reviews is insane ottosr.com

🚨Phase 2 study: Bevacizumab + erlotinib shows promising activity in advanced papillary RCC! ✅ Hereditary leiomyomatosis and renal-cell cancer (HLRCC)-associated papillary RCC: ORR 72%, median PFS 21.1 mo, OS 44.6 mo (N=43) ✅ Sporadic papillary RCC: ORR 35%, PFS 8.9 mo, OS

Bowel anastomosis. Circa 1953. No Staplers. Surgical Techniques by Partipilo.

Last day of SUO fellowship, had great experience at USC Urology and learned so much from Sia Daneshmand, M.D. Anne Schuckman Dr. Hooman Djaladat Amir Lebastchi, MD. Appreciate the tremendous support from family and friends. Now it is time to go back home Penn Urology.

ctDNA can help guide adjuvant decision making in MIBC In pts with undetectable ctDNA after NAC + cystectomy, no definitive benefit for adjuvant ICB authors.elsevier.com/c/1lMET14kpm0h… Matt Galsky The Tisch Cancer Institute Icahn School of Medicine at Mount Sinai Uromigos Bladder Cancer Advocacy Network UroToday.com World Bladder Cancer Patient Coalition OncLive.com

A very sad day learning that a giant in urology passed, Donald G. Skinner MD His impact was profound. His commitment to surgical excellence was only matched by his devotion to pt care and teaching. Simply the best mentor, colleague and friend RIP Boss Society of Urologic Oncology Amer. Urol. Assn.

🔥Our new video article has just been published in Journal of Endourology #Videourology Mary Ann Liebert Inc Amir Lebastchi, MD Erika L. Wood, MD,MPH USC Urology #ProstateCancer #FocalTherapy 🔗liebertpub.com/doi/10.1089/vi…

Should #radicalcystectomy ever be considered for consolidate therapy post EV/P?dailynews.ascopubs.org/do/personalizi… Petros Grivas Shilpa Gupta Tom Powles Matt Galsky Oncology Brothers Sumanta K. Pal, MD, FASCO Yüksel Ürün niraj Ashish M. Kamat, MD, MBBS IBCG SWOG Cancer Research Network Society of Urologic Oncology Bladder Cancer Advocacy Network

What a fantastic tool! Thanks for sharing. Kari Tikkinen Brian Hu Saum Ghodoussipour Vignesh Packiam, MD Muhannad Alsyouf Antoin Douglawi Leilei Xia Alireza Ghoreifi, MD Domenique Escobar, MD 👩🏽‍⚕️🧜🏽‍♀️

💉 “Give a fluid challenge — see if we can get the norad down.” We’ve all heard it. Boluses are often given just to reduce vasopressor doses. Why? • Fear that pressors are harmful • Pressure to keep patients off ICU But topping up to drop the norad might not be the best move…

🌟🎓✔️🖋MUST READ Key Updates in Testicular Cancer: Optimizing Survivorship and Survival 👨‍⚕️ Authors: Dr. Lawrence Einhorn DrBagrodia Ragnhild Hellesnes Lucia Nappi Sia Daneshmand, M.D. University of British Columbia  Testicular Cancer Society IU School of Medicine Indiana University Department of Urology  IU Simon Comprehensive Cancer Center OncoAlert 🔹 Testicular cancer: high

NEW PAPER in The BMJ "Dealing with continuous variables and modelling non-linear associations in healthcare data: practical guide" --> bmj.com/content/390/bm… #methodologymatters

"Good decision-making does not entail hiding a professional opinion; it requires engaging in genuine deliberation with a patient." Read this Viewpoint about the complexities of surgical decision-making. ja.ma/44Tlrug