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New with Anne Richelle , we developed a framework for inferring the specific metabolic functions of a tissue or cell line to aid in building large metabolic networks of the tissue or cell line of interest doi.org/10.1371/journa… PLOS Comp Biol

A computer model attempts to simulate the metabolic network of a minimal cell with 493 genes elifesciences.org/digests/36842/…

A new, experimentally defined annotation of the Chinese hamster genome, plus the identification of endogenous retroviral elements that have added a significant cost to biopharmaceuticals for decades pubs.acs.org/doi/10.1021/ac…

Congrats to Julie la Cour Karottki @kjlack, our adopted lab member, for an excellent PhD thesis defense on the use of #CRISPR a/i and pooled screens in CHO cells! DTU Biosustain

We engineered cleaner drug producing mammalian cells by knocking out more than a dozen genes, leading to better growing cells, enhanced recombinant protein production, and more pure antibody production. Check out our preprint: biorxiv.org/content/10.110…

Just came out today... by targeting two transcription factors concurrently, we engineered innate immunity in mammalian cells to make them resistant to multiple RNA viruses: rdcu.be/bHkX5

Hooman will be presenting on the "Complete Elimination of the Warburg Effect in CHO Cells", this Thursday at the Bioprocessing Summit (#BPSMT). Come join!

Enjoyed you guys' booth at the Bioprocessing Summit! (#BPSMT)

UCB researcher Dr. Rana Sidhu spoke today at the Cambridge Healthtech Institute #BPSMT event about the new strategies our scientists are using to better understand proteins that are challenging to study: ucbusa.news/2YXoOPP

Enjoyed Jamey Young's CHO productivity and mitochondrial metabolism presented at the Bioprocessing Summit! #BPSMT VU Engineering

Enjoyed your talk and exciting results with the Beacon technology #BPSMT

Mortiz von stosch from #Glaxo on ML applications in bioprocessing: ready-now (concise problem with lots of data) versus ready-later (hybrid models with broad implications). #ArtificialIntelligence #BPSMT See also: aiche.org/chenected/2014…

Will Johnson from Amgen 🧪🔬🧬 presenting on multivariate, multi-scale, modular modeling of bioprocessing at #BPSMT. From bioreactor fluid dynamics to cellular metabolism to subcellular organs. Cool stuff!

Making Goodsell illustrations sciencedirect.com/science/articl…

Jahir Gutiérrez-Bugarín, Ph.D and Amir Feizi mapped out the mammalian secretory pathway, connected it to a genome-scale metabolic model, and showed we could predict an increase in antibody secretion with a gene knockdown. @NIGMS DTU Biosustain nature.com/articles/s4146…

Standard bioinformatic pipeline x.com/AMAZlNGSCIENCE…

Latest work from Anne Richelle. We developed a tool that used systems biology models to precompute the genes needed for a cell to accomplish a metabolic task, and now you can overlay your omics data to see what your cell is doing using GenePattern. bioRxiv: doi.org/10.1101/2020.0…

Our 14 protein knockout cell line work was highlighted in GenEng News: "Genome Editing Helps Cell Lines “Clean Up” Their Protein Production" @favprotchemist Daniel Ley Jahir Gutiérrez-Bugarín, Ph.D Wan-Tien Chiang DTU Biosustain genengnews.com/news/genome-ed…

What you eat, given your microbiome, can affect your response to drugs without altering the drug (at least if you're a worm). Great collaboration with the O'Rourke lab nature.com/articles/s4146…