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Wrote a piece on a few recently published molecular glue degraders with atypical mechanisms of action. Check it out! pubs.acs.org/doi/10.1021/ac…

This is legit, out of the world.

Excited to present our work on how cells detect the deleterious absence of reactive oxygen species, or reductive stress. Meet a very small #molecularglue for a #ubiquitin ligase and a new regulator of #mitochondria. (1/n) cell.com/cell/fulltext/…

It is our sincere pleasure to reveal that Professor Benjamin F. Cravatt III of Scripps Research Translational Institute is one of the 2022 #Wolf Prize laureates in Chemistry.

6/11. This point was emphasized in research from Haian Fu's lab at Emory where missense oncogenic alleles were found to alter interactomes frequently. cell.com/cell/fulltext/…

How cool is that? New paper nature, E3 #ubiquitin ligases keep on giving #Proteindegraders #PROTACs nature.com/articles/s4158…

I've always been somewhat skeptical about bifunctional modalities due to their "expected" poor PK/PD, but many molecules surprised me with their superior efficacy despite their bizarre shape, and now we got some clues - groundbreaking work from Kevan Shokat science.org/doi/10.1126/sc…

A very informative read! Protein–protein interfaces in molecular glue-induced ternary complexes: classification, characterization, and prediction Drs. Jaeki Min P. Ryan Potts, Ph.D. Congratulations! lnkd.in/gWFQidGw lnkd.in/gSPrKTHz

Great paper by the group of @georg_e_winter in J. Am. Chem. Soc.. They establish a luciferase-based screening platform that allows the systematic identification of new E3 ligases amenable to molecular glue design as well as their degradation targets. doi.org/10.1021/jacs.2…

Gene therapy landscape I pulled together 42 public companies and charted the preclinical & clinical assets of each, segmented by approach & vector Some takeaways:

A study by Genentech with huge implications for #TPD & #PROTAC space (efficacy & safety): Induced degradation of certain proteins generates peptides which bind to & induce cIAP1 autodegradation, leading to caspase activation & cell death. bioRxiv biorxiv.org/content/10.110…

nature.com/articles/s4157…

1/9 What happens when covalent chemistry meets molecular glue? The Ebert Lab, Fischer Lab, and Gray Lab discovered a trans-labeling covalent mechanism we termed “template-assisted covalent modification” from a new class of DCAF16-based BRD4 degraders.biorxiv.org/content/10.110…

Congrats to our College of Chemistry chem bio graduate Ellie King for her CellChemicalBiology publication on using chemoproteomic approaches to discover a covalent molecular glue degrader that exploits an E2 UBE2D to degrade NFKB1! Glad to have this published! sciencedirect.com/science/articl…

Join for DCAF16-focused seminars: Yen-Der Li Yen-Der Li (Ebert Lab), Michelle Ma (Fischer Lab), and Muhammad Murtaza Hassan Muhammad Murtaza Hassan (Gray lab). As well as Matthias Hinterndorfer Matthias Hinterndorfer (@georg_e_winter), Ollie Hsia Ollie Hsia, and Angus Cowan (Alessio Ciulli lab)

Excited to see our ACS Central Science paper published on rational design of molecular glue degraders via a transplantable covalent handle! Congrats to Ethan Toriki, James Papatzimas, Novartis Science, and team! Thanks also to The Mark Foundation for Cancer Research! College of Chemistry pubs.acs.org/doi/10.1021/ac…

1/8 💡🦠 Can we harness human E3 ligases for antiviral defense? Are human E3 ligases involved in maintaining SARS-CoV-2 virus stability? Our pandemic research project is finally published! #COVID19 #E3Ligase cell.com/iscience/fullt…

DCAF16-focused seminars are now available online: youtube.com/watch?v=hri_Rz… youtube.com/watch?v=mRuiNR…

Congratulations to ALL 2023 Graduates! Harvard Griffin GSAS Hasreet Gill @anuraglimdi Gal Lum Kalki Kukreja Jiseon Min Julien Barrere Sylvia Hurlimann Kumaresh Krishnan Yen-Der Li mcb.harvard.edu/department/new…

A new paper from Benjamin Ebert, Nathanael Gray, Eric Fischer, Fischer Lab, Yen-Der Li, Michelle Ma, and Muhammad Murtaza Hassan reports a trans-labeling mechanism “template-assisted covalent modification”, which enables proximity-driven pharmacology rdcu.be/dPzUW