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▶️ Looking for flexible submission checklists? We're launching the AGA Quick Submit process soon for all Original Articles and Research Letters, which also includes fewer additional information questions upon submission 🥳 Submit now! ow.ly/E5CW50VBZKP American Gastroenterological Association (AGA)

🆕 Study in CMGH Cholinergic & nitrergic neurons in the colon show distinct activity around contractions Specific neuronal activity patterns underlie specific stimuli #GITwitter cmghjournal.org/article/S2352-…

📍 Attending #DDW2025 in May? Don’t miss the exciting American Gastroenterological Association (AGA) journal events at AGA Central! 📖 🖇️Learn more: ow.ly/YECP50VCY6l #GItwitter

Check out this featured article ➡️ Prostaglandin E2 and Akt Promote Stemness in Apc Mutant Dclk1+ Cells to Give Rise to Colitis-associated Cancer 🔗 ow.ly/KmFj50VGjQA

1/ ⏰ for #EBGI Tweetorial🧵w/ Mythili Menon Pathiyil(she/her)! “Redefining Risks in CDH1 Hereditary Diffuse Gastric Cancer” 📜Summary bit.ly/4cTynTn 🎧 Podcast bit.ly/4lUmoJo 📰Article bit.ly/4jyift7 #GITwitter

Onsite at #EASLCongress 2025? Catch these EASL Education events live in Amsterdam! 👇 📘EASL Journal Club: events-apps.easl.eu/easl2025/en-GB… 🧬EASL Molecular Tumour Board: events-apps.easl.eu/easl2025/en-GB… 🧪EASL Genetic Grand Round: events-apps.easl.eu/easl2025/en-GB… #LiverX #EASLGGR #EASLMTB #EASLJC

🎓 Deepen your expertise in autoimmune & cholestatic liver diseases at the Postgraduate Course! Explore PBC, AIH, IgG4-RC, and #PSC with leading experts. 🗓️Wednesday, 7 May from 0830 CEST 👉easlcongress.eu/2025-scientifi… @EASLNews Mike Carbone Emma Culver Sven Francque Lindsey Kennedy

Nora Cazzagon on extra-hepatic autoimmune conditions: 👉Autoimmune comorbidities in #PBC are common and clinically relevant. 👉Up to 60% of PBC patients present with extrahepatic autoimmune disease. 👉Data show strong links with conditions like Sjögren’s, thyroid disease & IBD

New therapies for symptom control in #PBC are on the horizon 🔬 Golexanolone targets fatigue via GABA-A modulation 🟡 PPAR agonists (bezafibrate, elafibranor, seladelpar) reduce pruritus 🧪 IBAT inhibitors (e.g. maralixibat) block bile acid reuptake Annika Bergquist

New advances in #PBC treatment at #EASLCongress: 🧪 Seladelpar and bezafibrate (both PPAR agonists) show significant biochemical response in patients with suboptimal UDCA response 📉 Seladelpar: ALP normalisation in 25% vs 0% (placebo) 📉 Bezafibrate: 56% ALP normalization at 1

EASLnews 🧪 PSC diagnosis and monitoring challenges ALP is widely used but has also a broad variation across patients. 👉🏽 ELF test and elastography are promising tools for prognosis - highlighted in the EASL CPGs on PSC: journal-of-hepatology.eu/article/S0168-… @EASLNews Marco Carbone Emma Culver

EASLnews Marco Carbone Emma Culver 🧲 MRI in PSC management Beyond standard MRI, tools like MRE, Anali score, MRCP+, and DiStrict score help assess fibrosis and disease activity with more precision. 🤝 Close collaboration between hepatology and radiology is essential @EASLNews Marco Carbone Emma Culver

Ana Lleo Catherine Frenette Phil Troke Lindsey Kennedy Ahmed Elsharkawy EASLnews Verena Keitel-Anselmino Palak Trivedi PBC Foundation When it comes to #PBC: ⚠️ 40% don’t respond to 1st-line therapy. 🚫 50% eligible for 2nd-line aren’t receiving it. Patients deserve access to live long & well. EASLnews #EASLcongress #LiverX

⏲️ We're going back in time to 2016 to see the top article from that year!! 📰 Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder 🔗 ow.ly/azyr50VR2E5

🐭 Here a group of authors genetically identified subtypes of myenteric neurons in unparalyzed preparations of mouse colon and observed that on contrast to previous reports. 🔗 ow.ly/FKm950VR66Q

📚 CMGH #EditorsEssentialReading 🚨Interferon-gamma (IFNg) signaling plays a critical role in eosinophilic esophagitis (EoE) 🔑IFNg alters epithelial behavior and barrier function 🧩Relationship b/t CD8 T cells, IFNg, and EoE cmghjournal.org/article/S2352-…

#ICYMI📣 The newest issue of CMGH is available! ⏲️ Take some time to read what published! 🔗 ow.ly/ayxw50VVyno

🚨 New study CMGH Erythropoietic protoporphyria (EPP) & liver disease 💊An OTC antihistamine (chlorcyclizine) might help 🎯Chlorcyclizine lowered PP-IX levels and reduced liver damage 🧪Repurposing antihistamines for possible EPP treatment 🔗cmghjournal.org/article/S2352-…

📚#EditorsEssentialReading in CMGH Extracellular vesicles released from adipose tissue in obese mice induce colonic fatty acid oxidation, growth, and stemness - helping define adipose-intestine communication & obesity-related GI disorders 🔗: cmghjournal.org/article/S2352-…

⭐ Featured Article ⭐ 📑 Inhibition of Ribosome Biogenesis In Vivo Causes p53-Dependent Death and p53-Independent Dysfunction 🔗 ow.ly/BYxt50VXPOB