Limited oxygen in standard cell culture alters metabolism and function of differentiated cells | The EMBO Journal embopress.org/doi/full/10.10…

A new technology developed at MIT enables scientists to label proteins across millions of individual cells in fully intact 3D tissues with unprecedented speed, uniformity, and versatility. picower.mit.edu/news/mit-metho… #neuroscience MIT ChemE Dept MIT Science MIT IMES MIT Brain and Cognitive Sciences

Immune mechanisms and shared immune targets in neurodegenerative diseases | Nature Reviews Neurology nature.com/articles/s4158…

GDF15 is turning out to be an extremely important protein (🧵) It's a stress-responsive cytokine, and the protein that's elevated in the most diseases (by far):

Lifestyle is a stronger predictor of aging and mortality than genetics. A new Nature study of ~500,000 people found: 🎯 17% of mortality variation was linked to lifestyle (exposome). 🧬 <2% of was explained by genetics. Here’s what you need to know 👇🧵 1/10

Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis | Nature Neuroscience nature.com/articles/s4159…

Ketones exhibit robust effects in restabilizing brain networks. 🧵1/9

In mitochondria, respiratory supercomplexes (blue) pump protons across crista membranes to create an electrochemical gradient, fueling adenosine triphosphate (ATP) synthase (pink) to regenerate ATP—the energy currency of life. Now, cryo–electron tomography captures these

Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice | Nature Communications nature.com/articles/s4146…

A single mitochondrial DNA mutation in mice causes autism-like behavior—social deficits, anxiety, and EEG disruptions—with no changes to brain anatomy. Let’s break it down 🧵1/10

Mitochondria and Inflammation: Is the Enemy Inside us? youtu.be/1ZCYloFYarY?si… #mitochondria #inflammation #ROS #endosymbiosis #mtDNA

NEW STUDY: It's dogma that fasting is good for you because it increases autophagy, the recycling of cell parts. But in the largest study ever, 6 months of time-restricted eating (TRE) or calorie restriction (CR) did not increase autophagy Huh? Is fasting still worth it? ... 🧵

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

NEW STUDY: 8 patients taking 1000 mg/d nicotinamide riboside (NR) for a month saw improvements in brain vasculature & cognition. What’s the evidence NAD boosters improve blood flow and cognition in humans? 🧠🧵

The first trial of creatine in Alzheimer’s disease was just published and the results are big. Patients took 20 grams of creatine monohydrate daily for 8 weeks. Brain creatine levels rose 11%, and cognition significantly improved across multiple domains, including memory,

When clinical Alzheimer's symptoms outpace biology – What does it really mean? New insight from JAMA Neurology. We’ve long relied on biomarker staging, particularly tau-PET and amyloid-PET scans, to tell us where a person is on the Alzheimer’s disease continuum. But what happens

"We thank the reviewers for their helpful comments"

We are happy to be seeking three post-docs across Edinburgh Napier, Glasgow & UCL in an exciting project to investigate mechanisms linking glial ageing/longevity & neurodegeneration (MRC-funded). Positions advertised, info attached (til end of June) Fiona Kerr Nathan Woodling

Tau fibrils drive Alzheimer's, but there are no approved therapies that directly target them This is a short peptide (discovered by Eisenberg lab, in Nature this week) that wraps itself around Tau fibrils and breaks them up:

INSANE Alzheimer’s Breakthrough. We may have a cure🤯 Groundbreaking Discovery - Lithium Could Reverse Alzheimer’s A stunning new study in Nature reveals that replenishing natural lithium levels in the brain may not only prevent, but also REVERSE Alzheimer’s disease.