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May is Brain Tumour Awareness Month Overall survival in Pediatric Brain tumours is >80% Don't Lose Hope !! #GoGrayThisMay #LetsSmileThisMay

The remarkable story of Velcade. In the year 2000, a few of us attended an angiogenesis meeting in Boston. We were there to discuss thalidomide But a side meeting that evening led to trial that went on to get Velcade FDA approved for myeloma. NEJM Story in thread.

IL-11–STAT3-axis drives astrocytes to induce TRAIL-dependent T cell apoptosis, suppress glioblastoma-specific immune reaction ➡️➡️ engineered therapeutic viruses can be used to target this astrocyte-driven immunoevasive mechanism 👇👇👇 nature.com/articles/s4158…

New Blood Advances issue out featuring: Glucagon-like peptide 1 receptor agonists and venous thromboembolism in type 2 diabetes: a target trial emulation ow.ly/kmwS50VXPEN

Overt and covert genetic causes of pediatric acute lymphoblastic leukemia | Leukemia nature.com/articles/s4137…

Cancer treatments and genetic predisposition are primary contributors to the risk of secondary neoplasms in childhood cancer survivors, and lifestyle factors seem to have a minimal effect 👇👇👇 thelancet.com/journals/lanon…

Avatrombopag is an effective oral treatment for children and adolescents with ITP for at least 6 months and has a reassuring safety profile in the paediatric population 👇👇 thelancet.com/journals/lanha…

Platelet Transfusion: 2025 AABB and ICTMG International Clinical Practice Guidelines | Bleeding and Transfusion | JAMA | JAMA Network jamanetwork.com/journals/jama/…

Long-term results of the RMS2005 trial confirm the survival benefit of maintenance chemotherapy with vinorelbine and low-dose cyclophosphamide for patients with high-risk rhabdomyosarcoma 👇 ascopubs.org/doi/abs/10.120…

Addition of ifosfamide 16 g/m2 (×6) to patients showing a poor response to preoperative MAP chemotherapy in high-risk osteosarcoma does not improve outcomes 👇👇👇 ascopubs.org/doi/10.1200/JC…

Blocking the TIM-3–Gal-9 axis in B-ALL can potentiate CAR-T function and promote tumor eradication 👇👇 ashpublications.org/blood/article/…

Check out this fantastic plenary paper from Kai Tan Lab and colleagues in Blood Journal: tinyurl.com/mr9nzj3k Michael Poeschla and I had the privilege to write a commentary, "Getting to the root of high-risk leukemias" tinyurl.com/htf3e8d2

Karua luettavaa: Suomessa todettiin vuonna 2023 yhteensä 39 199 uutta syöpää ja syöpään kuoli 13 645 henkeä. Mutta ennusteen mukaan vuonna 2040 uusia syöpiä todetaan jo lähes 49 000 vuodessa 👇👇👇 syoparekisteri.fi/raportit-ja-ka…

We're one, but we're not the same We get to carry each other, carry each other – U2