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Our latest Message from the Director highlights an NIDCD workshop on using existing technologies and developing new tools to advance non-invasive and minimally invasive imaging of the human olfactory (smell) system. Read more: go.nih.gov/Kzju9gG #NIDCDresearch

nygenome.org/news-events/ne… Exciting news for New York Genome Center, Columbia and Biochemistry & Molecular Biophysics

Explore this gift article from The New York Times. You can read it for free without a subscription. nytimes.com/2025/03/31/bus…

A non-coding role for trypanosome VSG transcripts in allelic exclusion biorxiv.org/content/10.110… Pretty cool observation! So many conceptual similarities between the regulation of olfactory receptor genes in mammals and surface glycoprotein genes in trypanosome and malaria!

The 2025 Breakthrough Prize in Life Sciences was awarded to: Drucker, Habener, Holst, Knudsen, and Mojsov for GLP-1/ozempic, Hauser and Ascherio for treating multiple sclerosis, and David Liu for CRISPR base editing. Terrific choices!

🔬 New from the Farnung Lab: We have established a fully in vitro reconstituted chromatin replication system and we report the first cryo-EM snapshots of the human replisome engaging nucleosomes. 🧬✨tinyurl.com/replisome

How does the brain respond to art? In a new PNASNews study, by showing paintings to people while scanning their brains, @dshohamy Celia Durkin & colleagues shed light on this question. Read: zuckermaninstitute.columbia.edu/art-brain-beho… @columbia @UMnews #neuroscience #art

When the Tavazoies work together magic happens! Congrats!

Hot-rodded vintage electron microscopes, around-the-clock shifts at the lab, huddles by a digital fireplace — and petabytes of brain connectivity data to show for it all. Glimpse our #electronmicroscopy team's tremendous work as part of the collaborative MICrONS program.

Biggest brain map ever details huge number of neurons and their activity nature.com/articles/d4158… a remarkable set of experiments that give new insight to brain function and were only possible due to NIH and the BRAIN initiative- taxpayer money in great use!

and of course in collaboration with the Allen Institute!

The brain as it's never been seen before. Scientists have created the largest wiring diagram and functional map of a mammal brain to date. @princetonneuro Johns Hopkins APL UW Graduate School @bcmfromthelabs @unigoettingen

"Thanks to a mouse watching clips from 'The Matrix,' scientists have created the largest functional map of a brain to date – a diagram of the wiring connecting 84,000 neurons as they fire off messages." ✍️ Lauran Neergard for The Associated Press 🔗 apnews.com/article/brain-…

Congrats to @columbia scientists Gary Struhl & Iva Greenwald for winning the Canada Gairdner Foundation ! The prize is for their research yielding critical insights on how cells communicate with their neighbors during development. Read more: zuckermaninstitute.columbia.edu/columbia-gaird… 🧠🏆🧠

Columbia Scientists Win International Award for Fundamental Research that Advances Understanding of Biology and Disease zuckermaninstitute.columbia.edu/columbia-gaird…

A significant amount of #research takes place in universities, “where doctors, scientists, and engineers make critical discoveries that lead to treatments people use every day," says James McKiernan, MD, CEO of ColumbiaDoctors. Every treatment has a journey of discovery.

Newly elected #NASmember Oliver Hobert of Columbia University and HHMI is interested in the developmental programs that generate the astounding diversity of cell types in a nervous system, using the nematode C. elegans as a model system. Read more: ow.ly/XkWJ50VAev0

Conserved energetic changes drive function in an ancient protein fold biorxiv.org/content/10.110… Same folds- different energetic requirements according to cellular function! New exciting preprint from Anum Glasgow Biochemistry & Molecular Biophysics

Happy birthday to #LaskerLaureate and #LaskerAwards Jury Chair Joseph Goldstein, who was recognized for the discovery of the basic mechanisms controlling #cholesterol metabolism. ow.ly/GPCl50NJv4u Read about his collaboration with Michael Brown: ow.ly/Z9Kl50NJv4v