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One of the trial designs that has been cropping up in discussions recently is the cluster randomised crossover, or CRXO, design. But when is it best used & what are the key issues to look out for? 1/7 #MethodologyMonday #119

Presented at #CCR25: In the ANH phase 3 trial involving adult patients undergoing elective cardiac surgery, acute normovolemic hemodilution did not reduce the number of patients receiving allogeneic red-cell transfusion. Full trial results: nej.md/3FxdMrW

🩸#ANHtrial results are live #CCR25 A survey from the authors: signavitae.com/articles/10.22…

🚨 Our fantastic #RCT just published in NEJM! 🚨 🩸 Can Acute Normovolemic Hemodilution (ANH) reduce RBC #transfusion in cardiac surgery? 🫀 ❓ What were the results? Click to find out 👉 nejm.org/doi/full/10.10… #CardiacSurgery #NEJM #PerioperativeCare

Rosario Losiggio, MD Valentina San Raffaele Anesthesia and Intensive Care Signa Vitae Giovanni Landoni, MD Fabrizio Monaco, MD Gianluca Paternoster Matteo Aldo Bonizzoni, MD Dra Ludhmila Hajjar Alessandro Pruna, MD Domenico Pontillo The ANH team on scene presenting and defending the ANH TRIAL in Belfast. Congratulations guys.

🩸Among adults undergoing cardiac surgery, ANH did not reduce the number of patients receiving allogeneic red-cell transfusion. These are the findings of the #ANHtrial, our latest multicenter RCT, just presented at #CCR25 and published in NEJM. 📎 nejm.org/doi/full/10.10…

Thanks to our Prof. Giovanni Landoni, MD , Dr. Fabrizio Monaco, and the entire team, a new international study led by #UniSR and IRCCS Ospedale San Raffaele has been published in NEJM to know more: unisr.it/en/news/2025/5…

A summary of the #ANHtrial presented by Valentina Fabrizio Monaco, MD & Giovanni Landoni, MD earlier this afternoon at #CCR25 and simultaneously published in NEJM San Raffaele Anesthesia and Intensive Care nejm.org/doi/10.1056/NE…

Live from #CCR25 in Belfast! Marilena Marmiere, MD is now introducing the background of the #PRINCEtrial! Looking forward to the results 😍

A brief summary of the methodology of the #PRINCEtrial Stefano Turi now on stage at #CCR25 Critical Care Reviews

#PRINCEtrial results just presented! Prof. Giovanni Landoni, MD revealed the findings: No difference in postoperative #myocardial #injury between patients who received #RIPC and those who did not #CCR25

Among adults undergoing noncardiac surgery, RIPC did not reduce myocardial injury or other postoperative complications. These are the findings of the #PRINCEtrial, our latest multicenter RCT, just presented at #CCR25 and published in Circulation. 📎 ahajournals.org/doi/10.1161/CI…

🚨 Just out in Circulation! Our PRINCE trial on remote ischemic preconditioning in non-cardiac surgery is now published! Masterfully presented today at Critical Care Reviews in Belfast by the amazing Giovanni Landoni, MD, Marilena Marmiere, MD , and Stefano Turi.

It’s out on Circulation: the #PRINCEtrial hits the stage at #CCR25! 🫀 RIPC before non-cardiac surgery: too good to be true? 👥 1,213 patients 🧪 RIPC vs sham 📉 No reduction in myocardial injury 🔗 ahajournals.org/doi/10.1161/CI… #RCT #PerioperativeCare Critical Care Reviews San Raffaele Anesthesia and Intensive Care

🚁 From this month, all 5 HEMS bases in Lombardy will carry blood components on board Marking a major step forward in prehospital care! 🩸 Huge kudos to Francesco Daminelli, Simone Celi & AREU - Lombardia for making it happen. 5 years since the first transfusion in Bergamo! 💪 #HEMS

Just got back from #CCR25! Hands down one of the best and most inspiring conferences in the world for anesthesia and critical care Already looking forward to the next one!

At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9 #MethodologyMonday #120

#TARGETProtein trial al centro del nostro prossimo Journal Club! 📆 Domattina, mercoledì 18 giugno | ore 07:00 CEST 📣 Dose proteica aumentata vs. standard in Pazienti Critici - da poco presentato a #CCR25 e pubblicato su JAMA DM per il link Microsoft Teams📹 🇮🇹

#ImpactFactor 2024! The Lancet 88.4 NEJM 78.5 JAMA 55.0 #IF2024

#IF2024 British Journal of Anaesthesia holds the highest #Impact #Factor in the #Anaesthesiology category this year! Meanwhile, PAIN Journal leads as the most cited journal in the field Here is the top10!