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Such a well deserved recognition of these two leaders for #mmsm

1/13 🤔Why does multiple myeloma cause anemia and not pancytopenia? If the issue is infiltration of the bone marrow with plasma cells, wouldn't all cell lines be low? Let's have a look.

⬆️ High levels of circulating tumor plasma cells as a key hallmark of aggressive disease in transplant-eligible patients with newly diagnosed #MultipleMyeloma 👉 fal.cn/3pFTE #JCO #MMSM Luca Bertamini

Nice article describing genetics of RR myeloma - what’s scarier though is all the CRBN mutations 🥶 With most degraders being IMiD based hopefully we find another E3-ligase with as small and moderately tight binder to explore with clinically #RRMM #TPD nature.com/articles/s4146…

Proud of Veli Bakalov, MD for his app being recognized by the The Lancet Haematology thelancet.com/journals/lanha… New heme-onc fellows should consider downloading this app- will help tremendously!

Great podcast, congrats to Raj Chakraborty. Highly recommended to all hem fellows! Morie Gertz you make me love WM. Incredible potential of twitter and podcasts for education

Finally meeting the CTC master! Bruno Paiva #IMS2022

Dancing with (MM) stars! Vincent Rajkumar JB Alberge . Not only science at #IMS !

Brilliant editorial comments by Morie - We hace always started with the wrong doses (too high). Need better Phase 1 studies - Sorely need QOL in trials - Importance of MRD negativity #IMS2022 #mmsm

Our paper were we redefine the reference intervals for serum FLCs and FLC ratio in individuals with chronic kidney disease using the #iStopMM data has been published! Full paper here: nature.com/articles/s4140… #mmsm #Nephrology Summary of the new reference intervals:

Two (mass spect) is better than one! MALDI buddies Habib El-Khoury, MD - Ghobrial Lab #mmsm

Our work is out in Cancer Cell! Read on to learn more about our use of single-cell RNA-seq to identify immune biomarkers of progression in a Phase II trial of EloLenDex in pts w/ high-risk Smoldering Myeloma (SMM).🧵👇 #mmsm authors.elsevier.com/c/1g4vW5TA51Zn… 1/

Excited to share our new research Cancer Discovery - MinimuMM-seq! A blood based approach for detection and WGS of circulating tumor cells for genomic profiling key myeloma biomarkers! An excellent joint effort! JB Alberge Daniel Auclair Gaddy Getz . #mmsm aacrjournals.org/cancerdiscover…

Follow-up data on the persistence of mass spec-detected monoclonal gammopathies from the Promise Study. TLDR; "Nevertheless, they persisted" #ASH22 abstract # 4538 presented by Habib El-Khoury, MD #mmsm

Myeloma docs mini mental status test: 1. Spell out two non-BCMA TCE targets 2. What if the PFS in MAIA? 3. Spell out the full generic name of ABECMA? 4. Is chromosome 1 prognostic? 5. Spell out and pronounce new drug that uses IFN PASS = 3 correct answers #ASH22RF #mmsm

Our article 'Prevalence of smoldering multiple myeloma based on nationwide screening' is out in Nature Medicine. A lot of work from the great iStopMM team behind this project ✨️ Sigurdur Kristinsson Sæmundur Rögnvaldsson, MD, PhD Malin Hultcrantz MD PhD @TBSsteharding C. Ola Landgren, M.D. nature.com/articles/s4159…

Almeno lasciate in pace le famiglie che vogliono stare insieme 🌈

End of October, time for changes. Thanks Ghobrial Lab . for the incredible opportunity and experience. Amazing colleagues & friends JB Alberge Habib El-Khoury, MD David Cordas dos Santos will miss you! Excited for next step @erasmusmcblood in the group of prof Sonneveld & Tom Cupedo

single-cell folks, what's the cell annotation tool do you recommend for immune cells and tumor cells? singleR? Seurat based label transfer? or sc-best-practices.org/cellular_struc… I still find myself using marker genes manually quite often