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Targeting epigenetic regulators prevents T cell exhaustion Science Magazine Caitlin Zebley, MD PhD Tae Gun Kang, PhD science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

In highly symptomatic #LongCOVID adults, 41% have objectively measurable microvascular dysfunction. From our collab Marcus Ståhlberg @JBruchfeld et al - amjmed.com/article/S0002-…

💡Thinking of using scRNA-seq to design antibody panels for spatial or single-cell profiling? Happy to launch Cytomarker, an interactive web-app and new antibody screening strategy to design and validate custom panels 1/6

New study of 74,000 participants found: -those infected with COVID had more other infections (including bacterial, influenza & mycoplasma infections) -COVID reinfections had milder acute-phase symptoms but led to higher rate & severity of #LongCovid thelancet.com/journals/lanwp… 1/

New paper 📢 Breastfeeding shapes developing immune systems. Here we report plasma protein differences at 1-yr in CHILD Cohort Study Spencer Ames Prof. Meghan Azad, PhD sciencedirect.com/science/articl…

Organoids. A super review of their role in cancer and potential to guide individualized treatment cell.com/med/fulltext/S… open-access Med by Cell Press Karolinska Institutet

🚨🚨 New Paper Alert 🚨🚨 I’m happy to share new #THRiVElab CHILD Cohort Study research - led by my MSc student Spencer Ames & published in American Journal of Clinical Nutrition - investigating #breastfeeding practices and infant immunity. #Tweetorial 🧵🧵 Full paper: doi.org/10.1016/j.ajcn…

Excellent talk on #SARS-CoV-2 persistence and #LongCovid by Dr. Michael Peluso. We’re glad to be supporting the UCSF LIINC study + tissue program via which much of the research has been performed. Learn more here: polybio.org/projects/liinc…

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? Latest from us. Published today. News here cuimc.columbia.edu/news/what-happ… article here: nature.com/articles/s4158… O'Jay Stewart BogunovicLab and a huge international team thank you 🙏🏼 Columbia Children's Health Lipschultz Precision Immunology Institute

Mothers keep on giving. A cool new study by Sing Sing Way team shows that the maternal microchimeric cells (carrying a wildtype complement C3 gene) can offset the severity of bacterial infection in offsprings (which are genetically deficient in C3) (1/) jci.org/articles/view/…

Biomolecular condensates: phasing in regulated host–pathogen interactions dlvr.it/THJVZm

Review Science Immunology Vidit Bhandarkar Stefani Spranger DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer science.org/doi/10.1126/sc…

New study paves way for immunotherapies tailored for childhood cancers news.ki.se/new-study-pave…

New paper alert📢! cell.com/cell/fulltext/… (Cell) - How does immune responses to solid tumors vary by age and tumor characteristics in children?! 🧵1/8

Super excited to share our new study from the Jason Buenrostro Lab in nature! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning. Paper: nature.com/articles/s4158…

General and individualized changes in T cell immunity during aging The Journal of Immunology doi.org/10.1093/jimmun…

Children born extremely preterm are born in the midst of a cytokine storm, its barrier tissues are poorly developed and they require invasive procedures which is associated with high risks of infections and inflammatory complications. Better understanding of how immune cells

An exceptional new NEJM review on cancer of unknown origin nejm.org/doi/full/10.10…

1/ We are delighted to share our work published in @SciImmunolgyidentifying the role of LY9 in CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis (science.org/doi/10.1126/sc…)

Immune development differs between preterm newborns fed mothers’ own m... sciencedirect.com/science/articl…