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Remarkable how study participation bias does not only change trait means/prevalences, but also changes how human traits correlate (r, rG) / causally relate to each other. Many links are weaker if participation bias is not taken into account! Study led by Tabea Schoeler

1/7 How do genetic variants affect co-expression patterns and how can this help us to interpret consequences of GWAS hits? In our latest preprint, we use scRNAseq to find such associations by mapping co-expression QTLs (co-eQTL)! doi.org/10.1186/s13059…

Here we present an unbiased longitudinal overview of the single-cell immune response after acute ST-Elevated Myocardial Infarction (STEMI) and compare this to controls (1/8) medrxiv.org/content/10.110…

I am happy to share the preprint on our single cell and multi-omics study of coronary syndromes. We find factors across data types that related to disease course and outcome. Nice team work with Corinna Kami Pekayvaz Monique van der Wijst Lude Franke Irene van Blokland RoyOelen @nicolai_leo

Zojuist werden de Ammodo Science Awards uitgereikt waarvan 2 van de 8 winnaars afkomstig van ⁦University of Groningen⁩. Hartelijk felicitaties voor ⁦Merel Keijzer⁩ ⁦Faculty of Arts - University of Groningen⁩ en ⁦Jingyuan Fu⁩ ⁦UMCG Genetica⁩ 👏💐

Dear Jingyuan Fu, Jingyuan Fu: many congratulations on this much deserved recognition for your fantastic work!!

Full summary statistics for our UKB-PPP GWAS of 1,463 circulating proteins are now available at synapse.org/#!Synapse:syn5… This includes full cohort (n=52,363), discovery (n=34,557), & African ancestry (n=931) analyses. More subpopulations (AMR, CSA, MID, EAS) available next week.

Interested in single-cell eQTL meta-analysis? Today, Dan Kaptijn will present results from the single-cell eQTL consortium at #eshg2023 at 10.30 in het Lomond Auditorium. Martijn Vochteloo will present results from the single-cell MetaBrain consortium at 13.00 (P21.019.C).

This afternoon at #eshg2023, Roy Oelen presents his poster at 3.45 (P06.018.B) on the single-cell analysis of myocardial infarction, available as preprint at medrxiv.org/content/10.110…

Today Robert Warmerdam at #ESHG2023 will present interim results of eQTLGen phase 2 (Clyde auditorium, 11.30 - 11.45): a genome-wide trans-eQTL analysis, with implications for many molecular QTL studies. Interested to join eQTLGen? Get in touch or go to eQTLGen.org

Tijs van Lieshout at #ESHG2023 shows that germline genetic risk factors in breast, prostate, colorectal and skin cancer can be linked to established somatic driver genes through tissue-specific gene regulatory networks. He is presenting poster P25.011.C from 13.00 - 14.00h today.

Martijn Vochteloo at #ESHG2023 has results on single-cell MetaBrain: a federated single-cell consortium for cell-type specific eQTL analysis in brain. He is presenting poster P21.019.C from 13.00 - 14.00h today. Interested in joining the MetaBrain consortium? Get in touch!

We are very proud that Monique van der Wijst Monique van der Wijst has been awarded a VIDI grant for her project to study gene expression variation. Monique, many congratulations! UMCG University of Groningen NWO Nieuws

Mooi nieuws: Moleculair bioloog Monique van der Wijst heeft een #Vidi-beurs van NWO Nieuws ontvangen voor haar onderzoek naar niet-genetische variatie in immuuncellen. Lees meer 👉nieuws.umcg.nl/w/vidi-subsidi…

The overlap between GWAS hits in cancer and established somatic driver genes is quite low. We observe that tissue-specific co-expression networks link the positional candidate genes in cancer GWAS to known somatic driver genes. Tijs van Lieshout explains below what we found:

Robert Warmerdam will present his work today on eQTLGen phase 2 at the ASHG: a full trans-eQTL meta-analysis across many blood cohorts and ancestries. Should you be interested in already working with interim freezes of eQTLGen phase 2: please get in touch with us!

Out now in Genome Biology: Martijn Vochteloo developed a method to identify 'principal interaction components' that maximise explained interaction variance of eQTLs. He is an excellent PhD student and looking for a postdoc position in Germany. If you have one, please contact him!

NEW PREPRINT! We have a new MR method called MR-link-2, which we validated extensively. Interested in Mendelian randomization? A🪡 below medrxiv.org/content/10.110…

Demuxafy: improvement in droplet assignment by integrating multiple single-cell demultiplexing and doublet detection methods. url.au.m.mimecastprotect.com/s/dmyICmO5nJhp… Led by Drew Neavin in collab with the sc-eQTLGen Consortium Lude Franke Shyam Prabhakar Lab Jimmie Ye @davisjmcc Marta Melé Martin Hemberg

Krista Freeman and Kaur Alasoo show in LCLs that trans-eQTLs can be highly cell-type specific. We are happy to have contributed with eQTLGen phase 2: we replicated some of these, but with much smaller effect-sizes in blood.