🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Interested in Cullin-RING E3 ligase networks? We developed synthetic antibodies specific for activated CRLs and used them to profile how CRLs adjust to cellular stimuli and small molecule degraders. Peter J Murray Matthias Mann Lab Sachdev Sidhu Max Planck Institute of Biochemistry (MPIB) bit.ly/3kjT57I

Excited to share the latest work from my time in the Garcia Lab: Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR), a Nanobody based, modular mix & match Targeted Protein Degradation (TPD) toolbox to target cell surface receptors. ACS Synthetic Bio pubs.acs.org/doi/10.1021/ac…

Work from Schulman lab Max Planck Institute of Biochemistry (MPIB) and St. Jude Research out Cell shows how CAND1 promotes exchange of F-box proteins in idle SCFs to recycle CUL1 and reveals a new paradigm for remodeling the cellular repertoire of multicomponent complexes. #OA tinyurl.com/bdnz25d6

Systemwide multiprotein complex formation visualized! CAND1 recycles Cullin-RING complexes to produce E3 #ubiquitin ligases. Averts cellular supply chain problems, prevents buildup of unneeded molecular machines & rapidly establishes degradation pathways ➡️tinyurl.com/bdnz25d6

Would not have been possible without amazing collaborators Danny and Lukas, and of course our amazing cryo-EM facility!!!!!!! Thank you all!!!!

Biogenesis of the largest family of E3 ligases revealed! Schulman lab, cryo-EM, biochemistry, and mass spec show rock-n-roll mechanism for systemwide assembly and disassembly of huge family of multiprotein cullin-RING ligase complexes by CAND1. tinyurl.com/bdnz25d6

Excited to share that our work on cullin-RING E3 ligase biogenesis is now officially out in Cell! A big thank you to Kheewoong Baek and @DanielS20127197 for letting me be a part of this journey. Max Planck Institute of Biochemistry (MPIB) Matthias Mann Lab St. Jude Research tinyurl.com/bdfftx5k

With only 2 days left here Max Planck Institute of Biochemistry (MPIB), great to see this out Cell! It was a fun time here making incredible friends, colleagues, and collaborators. Will miss this place but also excited for the future!!!

Which cullin-RING E3 #ubiquitin ligase directs your favorite pathway or your #DegraderDrug? Our conformation specific antibody and probing of active #CRL E3 complexes is in Nature Chemical Biology! ❕mpg.pulse.ly/3m3asipuew ❕nature.pulse.ly/l6c644umev Matthias Mann Lab Peter J Murray Lukas Teoman Henneberg

This week in the TPD seminars we are hosting two excellent speakers Kheewoong Baek and Lukas Teoman Henneberg sharing stories from work completed in Prof. Brenda Schulman's lab at Max Planck Institute for Biochemistry ! See you at 11am EST!!!

I am looking forward to the seminar by Kheewoong Baek and Lukas Teoman Henneberg from Brenda Schulman's lab tomorrow. Join us at 11am EST.

How does multisite #phosphorylation of an #E2 enzyme dictate its pairing with a multisubunit #E3 #ubiquitin ligase to regulate metabolism? Check out our story available now in Molecular Cell! ➡️ cell.com/molecular-cell… D.Sherpa Schulman lab Max Planck Institute of Biochemistry (MPIB)

Check out our story revealing exciting regulation of the NAD+ biosynthetic enzyme NMNAT1 by the supramolecular CTLH E3 ligase assembly out in Molecular Cell! ➡️cell.com/molecular-cell… Karthik Gottemukkala, D.Sherpa, Arno Alpi Schulman lab Max Planck Institute of Biochemistry (MPIB)

Congratulations to Anna Uzonyi of Weizmann Institute & Lukas Teoman Henneberg of Max Planck Institute of Biochemistry (MPIB), winners of the Amon Young Scientist Awards. They’ll present at the Amon Awards ceremony at the KI on 11/14 at 2 p.m. The MIT community & Amon Lab alumni are invited. mit-ki.org/4g5Gb5P

🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and Jacob Corn. Special shutout goes to @matthias_muhar nature.com/articles/s4158…