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Huge congrats to the next generation of Mike Mitchell stars Hannah Yamagata Amanda Murray for crushing their Penn Bioengineering PhD qualifier exams! Be on the lookout for exciting new mRNA LNP vaccines and cancer therapeutics from them in the near future!

Huge congrats to Mike Mitchell Postdoc Ningqiang Gong (now Prof USTC Global) for being selected for the cover of @natbme for his new switchable bispecific T cell engager tech to safely eliminate solid tumors! Paper: nature.com/articles/s4155… Penn story: penntoday.upenn.edu/news/switchabl…

Check out our latest in ACS Nano ACS Nano led by Mike Mitchell PhD student Alex Hamilton Alex Hamilton on high-throughput in vivo screening to identify LNPs tailored for local and systemic delivery for mRNA vaccines + cancer immunotherapy applications! Link: pubs.acs.org/doi/full/10.10…

Thrilled to share our latest in Nature Reviews Drug Discovery Nature Reviews Drug Discovery led by former Postdoc Ningqiang Gong (now Prof USTC Global) in collaboration with The Drew Weissman Lab on drug delivery technologies for generating cancer vaccines in situ! Free access: rdcu.be/dMsLv

Thrilled to share our latest in Nature Chemistry led by Mike Mitchell Postdoc Xuexiang Han (now Prof at SIBCB) on fast (less than hour) and facile synthesis of new cationic lipids for mRNA delivery beyond the liver! Free access: rdcu.be/dNchb penntoday.upenn.edu/news/penn-pion…

Blessed to have such rockstar PhD students like Roro! Check out roro’s latest in PNAS on in utero gene editing of hematopoietic stem cells using a new targeted lipid nanoparticle platform!

Understanding how solid tumors resist treatment is key in the fight against cancer. Mike Mitchell is exploring tumors' “security system” to weaken their defenses, as published in Nature Materials. Read more: bit.ly/4dRz27l

Check out our latest in Advanced Drug Delivery Reviews Editors of Advanced Drug Delivery Reviews led by Mike Mitchell undergrad Kaitlin Mrksich and postdoc Marshall Padilla on the evolution of ionizable lipid structure to enhance endosomal escape and mRNA delivery! Free access: authors.elsevier.com/a/1jrRm,3sXTmU…

Imagine a future where medicine sends treatments exactly where they’re needed. Mike Mitchell & Lulu Xue, Ph.D of Penn Bioengineering have developed siloxane-enhanced nanoparticles (SiLNPs) to transform personalized medicine & gene therapy. bit.ly/4dtraIg

Thrilled to see our siloxane-incorporated LNP for tissue-specific mRNA delivery out today Nature Nanotechnology ! So many thanks to all the amazing support from Mike Mitchell and all the great help from friends and collaborators Gan Zhao Ningqiang Gong Andy Vaughan also on bluesky Penn Engineering

Mitchell Lab is off to Baltimore to give 18 presentations at #BMES2024, including 10 talks on mRNA LNP technology for immunotherapy, vaccines, pregnancy, crossing the blood-brain barrier, and more! We are hiring Postdocs and PhD students, come chat with the team if interested!

We will have six additional posters by Lulu Xue, Ph.D, Hannah Yamagata, Dongyoon Kim, roro, Ben Nachod, and Sri Teerdhala on lipid nanoparticles for mRNA vaccines, gene editing of HSCs, treating fibrosis, and NK cell engineering

Batting leadoff for Mike Mitchell this morning is roro presenting his recent work in PNASNews on in utero gene editing of stem cells using targeted lipid nanoparticles! Dongyoon Kim Lulu Xue, Ph.D also have exciting posters on mRNA cancer vaccines and treating fibrosis!

18 presentations and 18,000 crabs later, beyond proud of the Mike Mitchell team for crushing #BMES2024! Be on the lookout for exciting new papers from the team in the coming weeks, and looking forward to seeing everyone at #BMES2025 in San Diego!

Research Briefing - Small structural changes in siloxane-based lipidoids improve tissue-specific mRNA delivery. nature.com/articles/s4156… Associated content - rdcu.be/dYvem

How do #ExtracellularVesicles act as corrupt shuttles for cancer therapeutics? nature.com/articles/s4156… Nature Materials Mike Mitchell The Drew Weissman Lab Penn Bioengineering ISEV @Lulu_xuee @JunhyongKim Xuexiang Han Rakan Alex Hamilton Junchao Xu Mohamad-Gabriel Alameh Gan Zhao Andy Vaughan also on bluesky

Check out our latest Nature Nanotechnology Nature Nanotechnology research briefing led by Lulu Xue, Ph.D and Kelsey Swingle on our siloxane lipid nanoparticle platform to deliver mRNA to cells and tissues across the body! Free access: rdcu.be/dYzDP Article: rdcu.be/dVGko

Excited to share our latest in Nature Biomedical Engineering Nature Biomedical Engineering led by Mike Mitchell Postdoc Xuexiang Han (now Prof at SIBCB) on directed chemical evolution to create next gen mRNA LNP therapeutics + vaccines! Free access: rdcu.be/d07M2 blog.seas.upenn.edu/cooking-up-a-b…

Excited to share our latest in nature led by Kelsey Swingle on new mRNA LNP tech to treat life-threatening pregnancy disorders! Kelsey shows that LNPs engineered to deliver mRNA to the placenta can normalize vascular tissue to ameliorate pre-eclampsia: blog.seas.upenn.edu/a-lipid-nanopa…

Thrilled to share that our lastest work published in J. Am. Chem. Soc.! Thanks so much Mike Mitchell for all the support and all the collaborators The Drew Weissman Lab Karin Wang help for developing ionizable lipid library for mRNA delivery to the spleen!