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We are happy to announce that our research article entitled "Loss of H3K9 tri-methylation alters chromosome compaction and transcription factor retention during mitosis" is now out on bioRxiv: biorxiv.org/content/10.110… MRC Laboratory of Medical Sciences (LMS) Imperial Medicine

This week we, ⁦Lymphocyte Development & Epigenetic Memory Groups⁩, are in Spa, Belgium for a joint retreat with Daniel Panne (@dpanne1 ⁦University of Leicester⁩) and Benjamin Rowland (The Netherlands Cancer Institute⁩) groups in this beautiful house

And it’s a wrap! Lymphocyte Development & Epigenetic Memory Groups, Rowland and @dpanne1 joint lab retreat comes to an end with a visit to Grottes de Remouchamps. Great few days with this wonderful bunch- lots of science and fun (and Belgian beer)!

What a wonderful week with the Lymphocyte Development & Epigenetic Memory Groups and the @dpanne1 labs! Great science, new insights and lots of fun (and exploring the hills by bike)!

Researchers Lymphocyte Development & Epigenetic Memory Groups MRC Laboratory of Medical Sciences (LMS) showed that a high-fat diet in mice can release silencing of the imprinted Dlk1 locus in subsequent generations via changes in microRNA expression. go.nature.com/3Ib8zCI

Thé ⁦Lymphocyte Development & Epigenetic Memory Groups⁩ group is ready for ⁦MRC Laboratory of Medical Sciences (LMS)⁩ rounders tournament! ⚾️

Thrilled to see my 5 years of work finally published. nature.com/articles/s4146…

Researchers MRC Laboratory of Medical Sciences (LMS) @IreneYNadie Lymphocyte Development & Epigenetic Memory Groups show inducible genes and enhancers are regulated mainly by transcriptional burst frequency that this is coordinated in single cells and individual alleles and requires cohesin. go.nature.com/3LDYNek

Our traditional Christmas dinner / secret Santa and once again a wonderful evening with Lymphocyte Development and Epigenetic Memory teams 🥳 MRC Laboratory of Medical Sciences (LMS) Imperial Medicine Imperial College London

We are happy to share that our study "Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis" is now out in NatureStructMolBiol lms.mrc.ac.uk/unlocking-the-… nature.com/articles/s4159… MRC Laboratory of Medical Sciences (LMS) Imperial Medicine

H3K9me3 is important for chromosome architecture and epigenetic memory during cell division. Drs. Amanda Fisher and Dounia Djeghloul's team showed that enzymes that catalyze H3K9 #methylation are retained on mitotic #chromosomes 🧬. Lymphocyte Development & Epigenetic Memory Groups MRC Laboratory of Medical Sciences (LMS) go.nature.com/3TzUB38

The #EpigeneticMemory group published in Communications Biology on a potential new therapeutic strategy for #DMD 🎉. Bioluminescent gene reporters were used to model #GeneExpression, and researchers found compounds that increase utrophin in developing muscle cells. 👉ow.ly/Xg8Z50NwWUK

A wonderful weekend read from us! Our study "Endogenous #bioluminescent reporters reveal a sustained increase in #utrophin gene expression upon EZH2 and ERK1/2 inhibition" is now out in Communications Biology Paper: nature.com/articles/s4200… MRC Laboratory of Medical Sciences (LMS) Imperial Medicine Story👇 lms.mrc.ac.uk/new-breakthrou…

Very excited to finally see our study out! We developed new models to study utrophin and dystrophin's gene expression patterns in vivo by bioluminescence and explored possible therapeutic options for Duchenne Muscular Dystrophy.

Gene Team – Mouse model for specialised molecular screening therapeutic strategies for #Duchennemusculardystrophy. Video & research by Hannah Gleneadie & Beatriz Fernandez-Ruiz et al Lymphocyte Development & Epigenetic Memory Groups MRC Laboratory of Medical Sciences (LMS) in Communications Biology. More on bpod.mrc.ac.uk/archive/2023/4… with MRC Laboratory of Medical Sciences (LMS) & John Ankers

#New publication by Epigenetic Memory makes exciting advances in using new #Bioluminescent tools in #epigenetic silencing research. These tools could aid the development of #epidrug therapies for diseases such as #cancer. 👉ow.ly/t7Uh50NMKzM Lymphocyte Development & Epigenetic Memory Groups Andrew Dimond nature

Happy to share our study in which we used Siamese neural networks to develop a #DeepLearning method for replicate-based analysis of chromosome conformation contacts, in collaboration with ⁦Daniel Rueckert⁩, spearheaded by ⁦⁦Ediem⁩ nature.com/articles/s4146…

.Ediem Lymphocyte Development & Epigenetic Memory Groups Daniel Rueckert adapt neural networks to the replicate-based analysis of Hi-C data and find that it successfully discriminates technical noise from biological variation. MRC Laboratory of Medical Sciences (LMS) Imperial College London #BiotechNatureComms nature.com/articles/s4146…

💡A living sensor to evaluate the impact of environment on gene expression & health. A new LMS Lymphocyte Development & Epigenetic Memory Groups study in Communications Biology uses the light of a firefly to illuminate cells, revealing how vulnerable our lungs are to external factors. Read more: lms.mrc.ac.uk/news/

Our latest study “Competition shapes the landscape of X-chromosome-linked genetic diversity” is now out in Nature Genetics