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Excited to share our new study in nature! We uncover how the vascular glycocalyx—a carbohydrate-rich coating on blood vessels—plays a crucial role in brain health and aging. A Tony Wyss-Coray & Carolyn Bertozzi labs collaboration. 🍭🧠 #glycotime (1/12) nature.com/articles/s4158…

Nice roundup on CRISPR genome editing The Economist economist.com/leaders/2025/0…

The 3D printing method used here produces calcium phosphate structures with ≈300 nm precision by using bioinspired chemistry and bone prenucleation nanoclusters. This method overcomes current fabrication limits and allows precise microstructure control. ow.ly/o6Xt50V8ixQ

Top 5 advances in medicine in February (🧵) 1. The first large trial to show that oxygen can improve outcomes in stroke Patients in this trial had acute ischaemic stroke (caused by a large vessel blockage in the front part of the brain) They received either 100% oxygen at 10

🚨📰TWEETORIAL time📰🚨 Excited to share recent work from our lab on noncoding genomics 🔎🧬: High-resolution CRISPR mutagenesis of the MYC TAD (~3 Mb) in 6 different human cancer cell lines nature.com/articles/s4146…

My continued biological education #Mechanobiology #RigiditySensing Stiffness Sensing by Cells "Substrate Stiffness Can Lead to Heritable Epigenetic Changes" "Stiff Substrates Induce an Inflammatory Phenotype" "Cell Motility Is Faster on Soft Elastic Substrates"

When it comes to explainable AI this is all one needs #xai

Top 5 advances in medicine this week (🧵) 1. Vitamin C modifies the amino acid, lysine, to form VitCyl-lysine This is a novel post-translational modification: it promotes immunity and (in mice!) boosts anti-PD1 immunotherapy to kill cancer Whether vitamin C can also boost

3. Remission can be achieved in type 2 diabetes, through weight loss, but how much is needed? This study found that every 1% decrease in bodyweight increases the chance of remission by 2% The method of weight loss doesn't matter: diet and exercise, GLP1s, surgery all work

BOOST: a robust ten-fold expansion method on hour-scale nature.com/articles/s4146…

AI-driven 3D Spatial Transcriptomics arxiv.org/abs/2502.17761

Nature research paper: Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease go.nature.com/4bAVCkF

Did you know that there is a complex interplay between mammalian lymph node (LN) fibroblastic reticular cells and their unique #ExtracellularMatrix? 📚 Read about it in Trends in Immunology: bit.ly/3Xn2ewU

BIG NEWS in Cell Reports! Adhesion strength of tumor cells predicts metastatic disease in vivo cell.com/cell-reports/f… In this work, we show that a physical property - adhesion strength - stratifies mouse and patient samples into disease and non-disease subtypes. (1/4)

For those who missed the talk due to time difference, you can access the recording here: mbi.nus.edu.sg/news/avery-sun…

A prelude to human hibernation: new study shows stimulation of the preoptic area of the hypothalamus is sufficient to induce hibernation-like states in mice, drastically reducing body temperature, metabolism and food intake, AND slowing epigenetic aging by up to 76%.

A computational framework developed by bianca dumitrascu, @halloulab and colleagues links transcriptomic analyses with mechanical signatures to study the interplay between cell mechanical forces and gene expression. nature.com/articles/s4159…

Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome🧵 Nature Medicine

🚀Exciting new review exploring the intersection of #mechanobiology & #AI! From predicting cell forces to analyzing complex genomic data, AI is unlocking new insights into how cells respond to mechanical cues. nature.com/articles/s4434…

CD45-PET Deferoxamine-labeled nanobody with PEG20 & 89Zr Highlighting spleen, liver, bone marrow, lymph node at baseline Outperforming FDG-PET on acute lung inflammation (LPS), acute colitis (DSS) in🐭 humanized probe longitudinally (up to 90-d) track major organ