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How do baculoviruses protect their genome? Delighted to present our findings in print! We use cryo-EM to determine the structure of a baculoviral nucleocapsid. We show how the tiny capsid protein VP39 assembles into a giant nucleocapsid. ❄️🔬 nature.com/articles/s4146…

Delighted to share new study by Tslil Ast now Weizmann Institute w/ Y. Itoh, D. Suess, Alexey Amunts https://bsky.app/profile/amunts.bsky showing (1) the Fe-S proteome is destabilized w/frataxin loss, (2) mitoribosome assembly factor METTL17 harbors a 4Fe-4S cluster, serving as an Fe-S checkpoint for mito translation.

Hypoxia rescue (& hyperoxia sensitivity) of mito CI mutants is evolutionary conserved! Harnessing the power of worm genetics, Josh Meisel w/ ⁦⁦⁦Gary Ruvkun⁩ discovers “hypoxia mimetic” and “hypoxia resistant” mutants, yielding key mechanisms. cell.com/cell/fulltext/…

Latest from the Hung group and colleagues: Genetic factors affecting storage and utilization of lipids during dormancy in Mycobacterium tuberculosis | mBio journals.asm.org/doi/10.1128/mb…

Researchers from Dept. of Molecular Biology, MGH and colleagues investigate cellular pathogenesis in Friedrich's ataxia, in a Molecular Cell study. doi.org/10.1016/j.molc…

Researchers from Dept. of Molecular Biology, MGH and colleagues investigate hypoxia-driven rescue of mitochondrial disease, in a Cell study. doi.org/10.1016/j.cell…

Meet #theNodeCorrespondents—Shreyasi Mukherjee In this interview, Shreyasi Mukherjee, a postdoc Dept. of Molecular Biology, MGH Harvard Medical School, talks about her ideas for the Node, including writing about stem cell-based embryo models and highlighting scientists from the Global South: thenode.biologists.com/meet-the-node-…

Imprinted X-chromosome inactivation through inherited silencing of the oldest genes -- Check it out here! And congrats to Chunyao Wei (with Hao Yin and Barry Kesner) for the outstanding work! sciencedirect.com/science/articl…

In a recent Molecular Cell publication, researchers from Dept. of Molecular Biology, MGH and colleagues discovered new insights into the silencing of X-chromosome genes passed from fathers to daughters. Read more: massgeneral.org/news/press-rel… Jeannie Lee #genetics #chromosome

@mrtbrandt and colleagues at Broad Institute Dept. of Molecular Biology, MGH @MGH_RI applied translational genetics to a rare CARD9 missense variant linked with dermatophytosis and uncovered a signaling switch that controls tissue immunity against fungal infection, now online in Cell Reports!

Leveraging our discovery of markers of mitochondrial disease, our collaborative team Mass General Brigham now reports plasma N-lactoyl amino acids and f-MET as markers of sepsis severity and mortality in the ICU. Metabolomics rdcu.be/dBGcC

Continuing our study of the somatic segregation of pathogenic mitochondrial DNA variants. T cell activation selects against the m.3243A>G variant in a manner that persists with time/age. Vamsi Mootha Broad Institute MGH Neurology Dept. of Molecular Biology, MGH pubmed.ncbi.nlm.nih.gov/38499449/

Very excited to see our work on PRC1 and chromatin condensation online Molecular Cell cell.com/molecular-cell… I am grateful to have worked with and learned from Sharon and Theresa Oei during this project! Many thanks to Radhika and Bob for their guidance and support throughout!

TODAY: at 2:00 PM EDT, Aleksandar Radakovic (BBS) defends his dissertation "Primordial role for RNA aminoacylation in the assembly of structured and functional chimeric RNAs". To access Zoom: projects.iq.harvard.edu/dmsdefenses BBS at Harvard

Researchers from Dept. of Molecular Biology, MGH and colleagues published the paper, small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation, in Science Advances this past month. Read more: doi.org/10.1126/sciadv…

Re-analysis of CLAP data affirms PRC2 as an RNA binding protein and XIST RNA as a target. We (YongWoo Lee, Roy Blum, Michael Rosenberg) examined the datasets of Guo et al. (PMID 38387462 - which reported that PRC2 is not an RBP) ... biorxiv.org/content/10.110…

(1/3) This important collab with Xiao Wang, out now in Nature Biotechnology, promises to expand the potential of mRNA-based therapies. The paper describes a method for systematic chemical modification and screening of synthetic #mRNAs to optimize their translation efficiency.

Manipulating cell fate through reprogramming: approaches and applications Read this Primer from Masaki Yagi, Joy Horng and Konrad Hochedlinger Dept. of Molecular Biology, MGH: journals.biologists.com/dev/article/15…

Congratulations to Victor Ambros UMass Molecular Medicine & Gary Ruvkun! The Nobel Prize

Nobel Laureate and HMS Professor Gary Ruvkun shared lighthearted tales about his start, a science revolution, and the power of worms.